Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer

Hong, Fengqiu; Geng, Xinyu; Min, Guangzong; Sun, Xin; Zhang, Bei; Yao, Youliang; Li, Ronghui; Wang, Jing; Zhao, Hengyu; Guo, Peng; Yuan, Zhen; Wen, Xiaofei; Nie, Liming; Liu, Gang; Chen, Xiaoyuan; Zhao, Qingliang

doi:10.1016/j.cej.2022.137846

Cited by 18 publications

(9 citation statements)

References 51 publications

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“…PTT is of great interest in cancer treatment because of its high performance in tumor ablation and minimal side effects [ 154 , 155 ]. In the PTT process, nanomaterials with strong absorbance convert light into heat to ablate cancer cells [ 156 , 157 , 158 ]. Despite the rapid development of photothermal agents in the last few years, their further clinical application is often limited by low photothermal conversion efficiency (PCE), poor water solubility, and non-biodegradability.…”

Section: Resultsmentioning

confidence: 99%

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

et al. 2023

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Conjugated polymers (CPs) have attracted much attention in the fields of chemistry, medicine, life science, and material science. Researchers have carried out a series of innovative researches and have made significant research progress regarding the unique photochemical and photophysical properties of CPs, expanding the application range of polymers. CPs are polymers formed by the conjugation of multiple repeating light-emitting units. Through precise control of their structure, functional molecules with different properties can be obtained. Fluorescence probes with different absorption and emission wavelengths can be obtained by changing the main chain structure. By modifying the side chain structure with water-soluble groups or selective recognition molecules, electrostatic interaction or specific binding with specific targets can be achieved; subsequently, the purpose of selective recognition can be achieved. This article reviews the research work of CPs in cell imaging, tumor diagnosis, and treatment in recent years, summarizes the latest progress in the application of CPs in imaging, tumor diagnosis, and treatment, and discusses the future development direction of CPs in cell imaging, tumor diagnosis, and treatment.

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Section: Resultsmentioning

confidence: 99%

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

et al. 2023

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“…In vivo, both subcutaneous [ 22 , 55 , 56 , 57 , 58 , 60 , 61 , 64 , 66 , 69 ] and orthotopic [ 51 , 62 , 67 , 70 ] murine models of bladder cancer were adopted. It should be underlined that although the subcutaneous model is relatively simple to obtain in animals with standardized procedures, the model closer to the pathological target in humans is the orthotopic one, where cancer cells are implanted in the organ/tissue matching the tumor histotype.…”

Section: Technical Clues For Nanoparticle-based Imaging Of Bladder Ca...mentioning

confidence: 99%

“…In most cases (especially in subcutaneous cancer models) NPs were administered i.v. [ 51 , 55 , 56 , 57 , 60 , 61 , 64 , 66 , 67 , 69 , 70 ] to verify their capability to systemically reach tumor cells. Alternatively, NPs were instilled in the bladder in order to assess their capability to cross the urothelial barrier [ 22 , 62 , 67 ].…”

Section: Technical Clues For Nanoparticle-based Imaging Of Bladder Ca...mentioning

confidence: 99%

“…Accordingly, some ex vivo studies were performed by installing the NPs into intact human bladders obtained from patients who underwent radical cystectomy [ 49 , 56 , 63 ]. In other studies, ex vivo analyses were performed on major organs or tumors excised from animals treated in vivo with NPs to confirm their biodistribution [ 22 , 55 , 57 , 58 , 60 , 66 , 67 , 68 , 69 , 70 ].…”

Section: Technical Clues For Nanoparticle-based Imaging Of Bladder Ca...mentioning

confidence: 99%

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Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Boschi

Malatesta

2023

IJMS

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Bladder cancer is very common in humans and is often characterized by recurrences, compromising the patient’s quality of life with a substantial social and economic impact. Both the diagnosis and treatment of bladder cancer are problematic due to the exceptionally impermeable barrier formed by the urothelium lining the bladder; this hinders the penetration of molecules via intravesical instillation while making it difficult to precisely label the tumor tissue for surgical resection or pharmacologic treatment. Nanotechnology has been envisaged as an opportunity to improve both the diagnostic and therapeutic approaches for bladder cancer since the nanoconstructs can cross the urothelial barrier and may be functionalized for active targeting, loaded with therapeutic agents, and visualized by different imaging techniques. In this article, we offer a selection of recent experimental applications of nanoparticle-based imaging techniques, with the aim of providing an easy and rapid technical guide for the development of nanoconstructs to specifically detect bladder cancer cells. Most of these applications are based on the well-established fluorescence imaging and magnetic resonance imaging currently used in the medical field and gave positive results on bladder cancer models in vivo, thus opening promising perspectives for the translation of preclinical results to the clinical practice.

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“…Malignant tumors can cause a decline in body immunity, are easily complicated by infection, and can lead to septic shock and death. − Compared with normal tissues, the tumor microenvironment (TME) exhibits many unique features, including extreme hypoxia, high levels of hydrogen peroxide (H 2 O 2 ) and glutathione (GSH), and a mildly acidic nature. − Aiming at the characteristics of tumor TME, phototherapy (including photothermal therapy and photodynamic therapy) has the advantages of low invasiveness, deep penetration, and high efficiency, and has been popular in anticancer approaches. − Photodynamic therapy (PDT) is usually an oxygen-dependent treatment; however, it is difficult to produce enough free radicals to kill tumor cells under extreme hypoxia in the TME, resulting in unsatisfactory therapeutic effects. − As an oxygen-independent treatment method, photothermal therapy (PTT) mainly uses the local high temperature generated by photothermal therapy agents under near-infrared (NIR) light irradiation to kill tumor cells . However, the heat shock effect, induced in tumor cells, weakens its therapeutic effect .…”

Section: Introductionmentioning

confidence: 99%

Hollow Nanooxidase Enhanced Phototherapy Against Solid Tumors

Wang

Jia

et al. 2022

ACS Appl. Mater. Interfaces

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Although phototherapy has attracted extensive attention in antitumor field in recent years, its therapeutic effect is usually unsatisfactory because of the complexity and variability of the tumor microenvironment (TME). Herein, we report novel CoSn(OH)6@CoOOH hollow carriers with oxidase properties that can enhance phototherapy. Hollow CoSn(OH)6@CoOOH nanocubes (NCs) with a particle size of ∼160 nm were synthesized via a two-step process of coprecipitation and etching. These NCs can react with O2 to generate singlet oxygen without hydrogen peroxide and consume glutathione, and their hollow structure can be utilized to carry drug molecules. After loading indocyanine green (ICG) and 1,2-bis(2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-yl) diazene dihydrochloride (AIPH), the resulting nanosystem (HCIA) exhibited enhanced phototherapy effects through the catalytic activity of oxidase, production of alkyl radicals, and consumption of glutathione. Cell and mouse experiments showed that HCIA combined with near-infrared laser irradiation significantly inhibited the growth of 4T1 tumors. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that PI3K-Akt and MAPK signaling pathways were highly relevant to this therapeutic system. Such hollow NCs with oxidase activity have considerable potential for the design of multifunctional drug delivery vehicles for tumor therapy.

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Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer

Cited by 18 publications

References 51 publications

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Hollow Nanooxidase Enhanced Phototherapy Against Solid Tumors

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