Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates

Cheng, Yu; Meyers, Joseph; Broome, Ann-Marie; Kenney, Malcolm E.; Basilion, James P.; Burda, Clemens

doi:10.1021/ja108846h

Cited by 273 publications

(227 citation statements)

References 64 publications

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“…To improve the nanoparticle delivery into tumors, functional nanoparticles, where the size of the nanoparticles shrank from 100 to 10 nm triggered by the matrix metalloproteinases overexpressed in the tumor microenviroment, exhibited both long circulation half-life necessary for the EPR effect and the deep tumor penetration for delivery into the tumor tissues in vivo (17). In addition, a novel approach of the noncovalent drug delivery by PEGylated Au NPs showed surprisingly efficient drug release and deep penetration into the center of tumor tissues (39). Taken together, the size of the nanomedicines critically affects the penetration and efficacy of the drugs in tumors.…”

Section: Penetration Behavior Of Gold Nanoparticles Into Tumor Spheroidsmentioning

confidence: 99%

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

et al. 2013

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Nanoparticles offer potential as drug delivery systems for chemotherapeutics based on certain advantages of molecular drugs. In this study, we report that particle size exerts great influence on the penetration and retention behavior of nanoparticles entering tumors. On comparing gold-coated Au@tiopronin nanoparticles that were prepared with identical coating and surface properties, we found that 50 nanoparticles were more effective in all in vitro, ex vivo, and in vivo assays conducted using MCF-7 breast cells as a model system. Beyond superior penetration in cultured cell monolayers, 50 nm Au@tiopronin nanoparticles also penetrated more deeply into tumor spheroids ex vivo and accumulated more effectively in tumor xenografts in vivo after a single intravenous dose. In contrast, larger gold-coated nanoparticles were primarily localized in the periphery of the tumor spheroid and around blood vessels, hindering deep penetration into tumors. We found multicellular spheroids to offer a simple ex vivo tumor model to simulate tumor tissue for screening the nanoparticle penetration behavior. Taken together, our findings define an optimal smaller size for nanoparticles that maximizes their effective accumulation in tumor tissue. Cancer Res; 73(1); 319-30. Ó2012 AACR.

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Section: Penetration Behavior Of Gold Nanoparticles Into Tumor Spheroidsmentioning

confidence: 99%

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

et al. 2013

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“…178 Also, some hybrid materials that combine photosensitizers and NPs have been described. [179][180][181][182] In all the above examples, PDT is achieved by direct light excitation of photosensitizers, which may be or may not be tagged on passive NPs, cf. Fig.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…15 The use of PEG to provide water solubility to the nanoparticles has been applied by Burda and co-workers for the synthesis of gold nanoparticles containing a noncovalently bound silicon phthalocyanine. [16][17][18][19] PEG has also been used to provide water solubility and to enhance in vivo accumulation in the tumour tissue by the enhanced vascular permeability and retention effect of gold nanoparticles functionalised with a hydrophobic zinc phthalocyanine. 20 Furthermore, PEG can also be a key building block in the synthesis of nanosystems for targeted photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy

Penon

Marín

Russell

et al. 2017

Journal of Colloid and Interface Science

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Photodynamic therapy (PDT) is a treatment of cancer by which tumour cells are destroyed using reactive oxygen species produced by photosensitisers following activation with visible or near infrared light. Successful PDT depends on the solubility and the targeting ability of the photosensitisers. In this work, the synthesis of a porphyrin-based water soluble nanoparticle conjugate containing a targeting agent that recognises the erbB2 receptor overexpressed on the surface of particular cancer cells is reported. The nanoparticle conjugates were synthesised following two different protocols, viz. a biphasic and a monophasic method, with the aim to determine which method yielded the optimal nanosystem for potential PDT applications. The nanoparticles were characterised using UV-Vis absorption and fluorescence spectroscopies together with transmission electron microscopy and zeta potential measurements; and their ability to produce singlet oxygen following irradiation was investigated following the decay in absorption of a singlet oxygen probe. The nanoparticles synthesised using the monophasic method were shown to produce the highest amount of singlet oxygen and were further functionalised with anti-erbB2 antibody to target the erbB2 receptors expressed on the surface of SK-BR-3 human breast cancer cells. The water soluble, antibody-porphyrin nanoparticle conjugates were shown to elicit targeted PDT of the breast cancer cells.

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Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates

Cited by 273 publications

References 64 publications

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy

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