To achieve the intelligent interception of different types of maneuvering evaders, based on deep reinforcement learning, a novel intelligent differential game guidance law is proposed in the continuous action domain. Different from traditional guidance laws, the proposed guidance law can avoid tedious manual settings and save cost efforts. First, the interception problem is transformed into the pursuit–evasion game problem, which is solved by zero-sum differential game theory. Next, the Nash equilibrium strategy is obtained through the Markov game process. To implement the proposed intelligent differential game guidance law, an actor–critic neural network based on deep deterministic policy gradient is constructed to calculate the saddle point of the differential game guidance problem. Then, a reward function is designed, which includes the tradeoffs among guidance accuracy, energy consumption, and interception time. Finally, compared with traditional methods, the interception accuracy of the proposed intelligent differential game guidance law is 99.2%, energy consumption is reduced by 47%, and simulation time is shortened by 1.58 s. All results reveal that the proposed intelligent differential game guidance law has better intelligent decision-making ability.