Deep sclerectomy with a nonabsorbable implant (T-Flux): preliminary results

Ateş, Halil; Üretmen, Önder; Andaç, Kutay; Azarsiz, Sertaç

doi:10.1016/s0008-4182(03)80027-3

Cited by 50 publications

(30 citation statements)

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“…Moreover, it has been suggested that the use of collagen drainage devices positioned under the scleral flap would improve aqueous humor filtration. [22][23][24] As only a few studies have directly compared NPS and TE, there is no strong evidence as to which surgical technique leads to the best results in terms of hypotensive effects and safety. The aim of this systematic review and meta-analysis of aggregate data is to fill this gap.…”

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confidence: 99%

Efficacy and Safety of Trabeculectomy vs Nonpenetrating Surgical Procedures

et al. 2013

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IMPORTANCETo date, only a few studies have directly compared nonpenetrating surgery (NPS) and trabeculectomy (TE). Therefore, there is no strong evidence as to which surgical technique leads to the best results in terms of ocular hypotensive effect and safety.OBJECTIVE To compare the hypotensive effect and safety of NPS and TE in terms of intraocular pressure (IOP) reduction and incidence of complications.DATA SOURCES The MEDLINE and EMBASE databases were searched for studies potentially eligible in any language published up to March 31, 2013.STUDY SELECTION Systematic review and meta-analysis of comparative studies of 2 or more surgical techniques (1 of which had to be TE), including patients with open-angle glaucoma. DATA EXTRACTION AND SYNTHESISThe considered interventions were TE, deep sclerectomy (DS), viscocanalostomy, and canaloplasty. MAIN OUTCOMES AND MEASURESThe primary outcome was the mean between-group difference in the reduction in diurnal IOP from baseline to the 6-or 12-month follow-up evaluation. We also considered the incidence of complications, expressed as relative risk.RESULTS Eighteen articles, accounting for 20 comparisons, were selected for data extraction and analysis. Analysis of the 6-month follow-up data showed that the pooled estimate of the mean between-group difference was −2.15 mm Hg (95% CI, −2.85 to −1.44) in favor of TE. There was no difference between the NPS subgroups. In the subgroup antimetabolite analysis, the addition of mitomycin C to TE and DS decreased the difference in the reduction in IOP (TE and DS without mitomycin C: −2.65 mm Hg [95% CI, −3.90 to −1.39]; TE and DS with mitomycin C: −0.83 mm Hg [95% CI, −2.40 to 0.74]). In the subgroup analysis by implant addition, no significant difference induced by DS with or without drainage devices was detected (test for subgroup differences: χ 2 1 = 0.24; P = .62). The absolute risk of hypotony, choroidal effusion, cataract, and flat or shallow anterior chamber was higher in the TE group than in the NPS group. CONCLUSIONS AND RELEVANCE Trabeculectomy seems to be the most effective surgical procedure for reducing IOP in patients with open-angle glaucoma. However, as expected, it was associated with a higher incidence of complications when compared with NPS.

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Efficacy and Safety of Trabeculectomy vs Nonpenetrating Surgical Procedures

et al. 2013

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“…After filtration surgery; proliferation of Tenon capsule fibroblasts cause fibrosis of the bleb and decrease efficacy of the surgery. To increase efficacy of the surgery new techniques are developed (10,15,16). MMC application is one of these techniques that we investigated in our study.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Clinical Results of Combined Phacoemulsification and Deep Sclerectomy with the Use of Mitomycin C at Different Sites

Aktaş¹,

Eltutar

Cilsim

et al. 2013

ELECTRON J GEN MED

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“…Twenty-five patients (25 eyes) with medically uncontrolled open-angle glaucoma underwent deep sclerectomy with the T-Flux NV®. For all postoperative visits, statistical analysis of success rates [74][75][76][77][78][79][80][81][82][83][84] revealed that deep sclerectomy with T-Flux NV® implantation was comparable to viscocanalostomy in a retrospective group of patients matched for age, sex, diagnosis, preoperative IOP, number of preoperative antiglaucoma medications and previous ocular surgery [5]. A noncomparative prospective pilot study, using the T-Flux NV® as intrascleral implant in a limited number of patients, showed no severe complications such as long-standing hypotony or endophthalmitis [24].…”

Section: T-flux (T-flux Nv® Iol Tech Laboratories France/now Carl Zmentioning

confidence: 99%