Deep-sea geohazards in the South China Sea

Wu, Shiguo; Wang, Dawei; Völker, David

doi:10.1007/s11802-018-3490-1

Cited by 29 publications

(15 citation statements)

References 36 publications

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“…Similarly, even though 6 compounds (cinnamaldehyde, styrone, (L)-alpha-terpineol, (À)-caryophyllene oxide, (Z)-caryophyllene, and [(1S)-endo]-(À)-borneol) had relatively small DL values, they were retained as active compounds from RG. [40][41][42]…”

Section: Active Compound Screeningmentioning

confidence: 99%

Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics

et al. 2018

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In this study, systems pharmacology was used to predict the molecular targets of You-gui pill (YGP) and explore the therapeutic mechanism of Kidney-Yang Deficiency Syndrome (KYDS) treated with YGP. On the basis of this, serum samples from control group, KYDS model group and YGP group rats were studied using 1 H NMR to verify the results of systems pharmacology from the level of metabonomics.Simultaneously, 1 H NMR spectra of serum samples were obtained and statistically assessed using pattern recognition analysis. Biochemical analyses of serums were performed via radioimmunoassays. Furthermore, histopathological studies were conducted on the pituitary, adrenal, and thyroid glands, and testicles of the control, KYDS and YGP rats. Using systems pharmacology to analyze the active components of YGP, 61 active compounds were finally found. These compounds were likely to have an effect on 3177 target proteins and involve 234 pathways. Using metabonomics to analyze serum from KYDS rats treated with YGP, 22 endogenous biomarkers were found. These biomarkers were mainly involved in 10 metabolic pathways. Combining systems pharmacology and metabonomics, we found that the regulation of KYDS was primarily associated with 19 active compounds of 5 Chinese herbal medicines in YGP. These active compounds mainly had an effect on 8 target proteins, including phosphoenolpyruvate carboxykinase, betaine-homocysteine s-methyltransferase 1, alcohol dehydrogenase 1C, etc. These target proteins were primarily involved in 6 overlapping pathways, namely aminoacyl-tRNA biosynthesis, glycolysis/gluconeogenesis, glycine, serine and threonine metabolism, valine, leucine and isoleucine biosynthesis, arginine and proline metabolism, and pyruvate metabolism. In addition, there were 4 non-overlapping pathways, respectively alanine, aspartate and glutamate metabolism, D-glutamine and D-glutamate metabolism, ubiquinone and other terpenoid-quinone biosynthesis, and galactose metabolism. In summary, the therapeutic effects of YGP on KYDS were mainly associated with neuroendocrine regulation, energy metabolism, amino acid metabolism, inflammatory responses, apoptosis, oxidative stress and intestinal flora metabolism. What's more, we also found that YGP possessed the potential to protect liver and kidney function. Our study demonstrated that systems pharmacology and metabonomics methods were novel strategies for the exploration of the mechanisms of KYDS and TCM formulas.

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Section: Active Compound Screeningmentioning

confidence: 99%

Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics

et al. 2018

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“…Slope failures represent a major threat, not only to the marine industry but also to the marine environment and coastal facilities [1]. They can lead to substrata instability and produce catastrophic losses in deep-water drilling and deep-sea cable and pipeline construction [4,17,[56][57][58][59]. Moreover, submarine landslides can generate devastating tsunamis [60][61][62][63][64].…”

Section: Slope Failurementioning

confidence: 99%

“…Mud volcanoes can have discrete eruptive events or periods of eruption that expel massive amounts of fine-grained sediments in periods that last for hours or centuries [79]. These events are potential geohazards for deep-marine infrastructures [10], as they may affect drilling operations, ring installations, and pipeline routings [4,8].…”

Section: Fluids Seepagementioning

confidence: 99%

“…Various geological processes and features can inflict hazards [4]. Some of them are well known due to their great destructive power.…”

Section: Introductionmentioning

confidence: 99%

“…Marine geohazard surveys have become increasingly relevant as exploration activities expand into deeper waters [4,16]. Some geohazards can generate damages to engineering structures, whose remediation is quite difficult, especially in very deep waters.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Marine Geohazards: A Bibliometric-Based Review

et al. 2019

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Marine geohazard research has developed during recent decades, as human activities intensified towards deeper waters. Some recent disastrous events (e.g., the 2004 Indian Ocean and 2011 Japan tsunamis) highlighted geohazards socioeconomic impacts. Marine geohazards encompass an extensive list of features, processes, and events related to Marine Geology. In the scientific literature there are few systematic reviews concerning all of them. Using the search string ‘geohazard*’, this bibliometric-based review explored the scientific databases Web of Science and Scopus to analyze the evolution of peer-reviewed scientific publications and discuss trends and future challenges. The results revealed qualitative and quantitative aspects of 183 publications and indicated 12 categories of hazards, the categories more studied and the scientific advances. Interdisciplinary surveys focusing on the mapping and dating of past events, and the determination of triggers, frequencies, and current perspectives of occurrence (risk) are still scarce. Throughout the upcoming decade, the expansion and improvement of seafloor observatories’ networks, early warning systems, and mitigation plans are the main challenges. Hazardous marine geological events may occur at any time and the scientific community, marine industry, and governmental agencies must cooperate to better understand and monitor the processes involved in order to mitigate the resulting unpredictable damages.

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Submarine geohazards on the northwestern continental margin of the South China Sea and their mechanism

Du,

Zhu,

et al. 2024

Geological Journal

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Submarine geohazards significantly threaten human economic activities and essential infrastructure. Based on multi‐beam data and high‐resolution 2D seismic data, two types of submarine geohazards are identified: direct and indirect geohazards on the northwestern continental slope and the Xisha Uplift of the South China Sea (SCS). Direct geohazards include submarine landslides and active faults, while indirect geohazards include buried channels, submarine canyons, pockmarks, volcanoes and magma diapirs. This study comprehensively analyzes geomorphological features, including their characteristics, genesis and distribution. Statistical analysis reveals that the gradient of the Xisha Uplift slope is steeper than the shelf break, making it a more unstable region. However, assessing disaster potential indicates that submarine geohazards at the shelf break pose a greater threat than those at the Xisha Uplift. Many factors, including tectonic activity, sediment supply and relative sea‐level changes, influence submarine geohazards' formation. These hazards do not occur in isolation but often interact with one another. The research results provide a scientific basis for predicting deep‐sea geohazards near the northern continental margin and Xisha Island in the SCS.

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Deep-sea geohazards in the South China Sea

Cited by 29 publications

References 36 publications

Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics

Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics

Marine Geohazards: A Bibliometric-Based Review

Submarine geohazards on the northwestern continental margin of the South China Sea and their mechanism

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