Art healing methods have gradually become a new outlet for the treatment of depression in recent years. In this paper, an expressive art healing method is proposed based on the condition of depression, and the treatment effect is predicted using the randomized forest method. The direction of influencing factor selection for depression is proposed from three perspectives: demographics, physical and cognitive health status, and mental health. After determining the influencing factors, the samples of depression were extracted, and the classification tree model was constructed using the C4.5 decision tree algorithm. The random forest mode classifier’s generalization error is identified, and the model’s overfitting problem is prevented by restricting the random forest’s convergence. Finally, the evaluation index of the model is proposed, and the prediction accuracy and effect of the random forest model are investigated through the combination of simulation experiments and practical application. The area under the ROC curve shows that the number of cases correctly categorized by the random forest prediction model before and after art healing is 456 and 468, respectively, and the AUC values are 0.8145 and 0.8265, respectively, which makes the model’s prediction ability better. From the prediction results of the random forest model, the intervention group has a significant difference from the control group in two aspects of paranoia level and horror mood, with p-values of 0.01 and 0.001, respectively, after the prediction of the random forest model has a better effect on the intervention of depression.