Africa displays a variety of continental margin structures, tectonic styles and sedimentary records. The comparative review of two representative segments: the equatorial western Africa and the SW Africa margins, helps in analysing the main controlling factors on the development of these margins. Early Cretaceous active rifting south of the Walvis Ridge resulted in the formation of the SW Africa volcanic margin that displays thick and wide intermediate igneous crust, adjacent to a thick unstretched continental crust. The non-volcanic mode of rifting north of the Walvis ridge, led to the formation of the equatorial western Africa margin, characterised by a wide zone of crustal stretching and thinning, and thick, extensive, synrift basins. Contrasting lithologies of the early post-rift (salt vs shale) determined the style of gravitational deformation, whilst periods of activity of the decollements were controlled by sedimentation rates. Regressive erosion across the prominent shoulder uplift of SW Africa accounts for high clastic sedimentation rate during Late Cretaceous to Eocene, while dominant carbonate production on equatorial western Africa shelf suggests very little erosion of a low hinterland. The early Oligocene long-term climate change had contrasted response in both margins. Emplacement of the voluminous terrigenous Congo deep-sea fan reflects increased erosion in equatorial Africa, under the influence of wet climate, whereas establishment of an arid climate over SW Africa induced a drastic decrease of denudation rate, and thus reduced sedimentation on the margin. Neogene emplacement of the African superswell beneath southern Africa was responsible for renewed onshore uplift on both margins, but it accelerated erosion only in the Congo catchment, due to wetter climatic conditions. Neogene high sedimentation rate reactivated gravitational tectonics that had remained quiescent since late Cretaceous.