Background: Chronic hip, knee, and ankle injuries are very common issues in the whole world. Musculoskeletal disorder hampers the development in several sectors including training and athletes' performance. Social, industrial, economic, and education declines are often caused by poor muscular-articular problems. This research aims to reveal the effectiveness of combine massage and physiotherapeutic exercises in:(1) the treatment of chronic hips, knee and ankle injuries;(2) improving and increasing the low limb strength and flexibility; (3) reducing the chronic pain of degenerative diseases; (4) improving the physical and mental wellbeing of human body; (5) increasing motor or sensory function; (6) increasing athlete's performance. This research is quasi-experimental with: quantitative approach. The sample of this study was 15 patients with chronic hips, knee and ankle injuries, taken by purposive sampling technique. The data were collected using measurement and treatment with combine massage and physiotherapeutic exercise. Data were analyzed using the descriptive statistics, independent sample t-test, paired sample t-test, and correlation among items using SPSS Amos.23. The result showed that there is a significant difference between pre-test-posttest strength measurement with P value (0.003<0.05). A significant difference between pre and posttest of all kinds of movement flexibilities is with the P value < 0.05. There is a strong correlation between combine massage and physiotherapeutic to the chronic knee, knee, and ankle with r >0.5. In conclusion, massage and physiotherapeutic exercise were found to be a vital part to improve human body health and it can be used by everybody.