Deep Ultraviolet Single‐Photon Ionization Mass Spectrometry

Abstract

The requirement of accurate analysis for organic chemicals has stimulated uprising research interest of single-photon ionization mass spectrometry (SPI-MS). Considering that ∼90% compounds bear absorption in the deep ultraviolet (DUV) region, it is crucial for SPI-MS applications to employ effective DUV light sources. Here, we summarize the advances of SPI-MS by utilizing deep ultraviolet lamps and lasers, including the combination with quadrupole mass spectrometer (QMS), ion-rap mass spectrometer (ITMS), and time-of-flight mass spectrometer (TOFMS) systems. We then emphasize on the newly developed SPI-MS instrument coupled with an all-solid-state deep ultraviolet (DUV) laser at 177.3-nm wavelength. The advantages of SPI-MS instruments have been illustrated on several organic compounds, where the capability of low fragmentation enables to identify chemicals from unknown mixtures.

Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility‐mass spectrometry

“…11 Since then, numerous studies have focused on characterizing fragmentation pathways of fentanyl and its many analogues with tandem MS, [12][13][14][15][16] including by both electrospray ionization (ESI) [17][18][19][20][21] and electron ionization (EI). [22][23][24][25][26] This has also led to the development of highresolution mass spectrometry (HRMS) methods becoming more routinely implemented for identification of fentanyl analogues and other new psychoactive substances (NPS), 27,28 along with the development of software tools to aid in screening. 29,30 Recently, ion mobility and mass spectrometry (IM-MS) have been coupled as a more comprehensive method for drug detection and quantification.…”