“…This large variation in risk may in part be explained by specific features of the central venous catheter, as e.g. catheter type and material, site, technique and level of insertion as reviewed by Van Rooden et al, 2005. Additional factors that have an impact on the risk of thrombosis in patients with central venous catheters include the number of punctures during catheter insertion, the duration of catheterization, the fluid administered, and catheter related infections (Koksoy et al, 1995;Hernandez et al, 1998;Martin et al, 1999).…”