Deep vein thrombosis of upper extremities due to reactive thrombocytosis in septic patients

Mishra, Shakti Bedanta; Bhoyer, Jashwini; Gurjar, Mohan; Muzaffar, Nabeel; Verma, Anupam

doi:10.4103/0972-5229.138162

Indian Journal of Critical Care Medicine

2014

DOI: 10.4103/0972-5229.138162

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Deep vein thrombosis of upper extremities due to reactive thrombocytosis in septic patients

Shakti Bedanta Mishra¹,

Jashwini Bhoyer²,

Mohan Gurjar³

et al.

Abstract: Deep venous thrombosis (DVT) is not an uncommon condition in the intensive care unit (ICU), and having high morbidity and mortality. Upper limb DVT also is increasingly being recognized as a clinical entity. The presence of the indwelling catheter in neck veins is a risk for developing venous thrombus, which may be further aggravated by presence of thrombocytosis. In ICU patients with sepsis, reactive thrombocytosis has been found during the recovery phase. Here, we are presenting two cases, having thrombocyto… Show more

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Cited by 3 publications

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Thrombocytosis Associated with Iron Deficiency Anemia; Is It a Masked Myeloproliferative Disorder?

Maral¹

2019

Ankara Medical Journal

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Objectives: Thrombocytosis is a frequent reason for hematological consultation. The etiology of thrombocytosis is classified as primary and secondary. While primary is result of clonal expansion due to myeloproliferative disorders (MPD), secondary thrombocytosis occurs due to a reactive state and regresses when that is resolved. Iron deficiency (IDA) is a frequent cause of reactive thrombocytosis in outpatients. The aim of this study was to investigate whether IDA and thrombocytosis mask a MPD in patients presenting with these complaints. Materials and Methods: This prospective study included 50 patients who were admitted to our hematology clinic with thrombocytosis and IDA. Causes of reactive thrombocytosis such as infections, surgery, malignancies, inflammatory diseases, asplenia, and pregnancy were excluded. All patients received oral or intravenous(iv) iron replacement as anemia treatment. Anemia and thrombocyte (PLT) count were measured and recorded initially and at the end of first month. JAK2 V617F (JAK2) mutation was also checked due to MPD investigation. Results: Hemoglobin (Hb) and ferritin levels increased in the first month of treatment (p<0.001). Higher ferritin levels were recorded in patients treated intravenously. A significant decrease was detected in PLT count following iron replacement (p<0.001). In 2 female patients no significant decrease was achieved in PLT count and the level persisted despite increases in Hb and ferritin level. Positive (JAK2) mutation was detected and MPD was diagnosed in these 2 patients. Conclusion: Clinicians should investigate patients presenting with IDA and thrombocytosis in terms of reactive causes such as infections, asplenia, malignancies, and inflammatory diseases. Furthermore, MPA should be kept in mind as well as other reactive causes if thrombocytosis persists despite successful IDA treatment.

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Thrombocytosis Associated with Iron Deficiency Anemia; Is It a Masked Myeloproliferative Disorder?

Maral¹

2019

Ankara Medical Journal

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TGF-β1 and Serpine 1 expression changes in traumatic deep vein thrombosis

Mo¹,

Zhang²,

Ji³

et al. 2015

Genet. Mol. Res.

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Reactive Thrombocytosis Leading to Recurrent Arterial Thrombosis Reversed by Management of a Prosthetic Joint Infection of the Hip

Papen¹,

Ghijselings²,

Vles³

2022

Cureus

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Prosthetic joint infections (PJIs) still pose a severe challenge for patients and the overall health care system. Infection, and PJI in particular, is a known cause of reactive thrombocytosis. Thromboembolic complications secondary to reactive thrombocytosis are infrequent and arterial thromboses are rarely described. We present the case of a 64-year-old female with reactive thrombosis and recurrent arterial thrombosis due to bilateral streptococcal PJI of the hip. Multiple episodes of acute ischemia of the right lower limb ultimately led to transfemoral amputation. Only after bilateral irrigation and debridement for infection control did the thrombocytosis resolve without any further thromboembolic complications. Early recognition of thrombocytosis, use of anti-platelet agents and early surgical treatment of the underlying infection (even when a conservative treatment may otherwise be considered) could have avoided this potentially life-threatening complication.

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Deep vein thrombosis of upper extremities due to reactive thrombocytosis in septic patients

Cited by 3 publications

References 7 publications

Thrombocytosis Associated with Iron Deficiency Anemia; Is It a Masked Myeloproliferative Disorder?

Thrombocytosis Associated with Iron Deficiency Anemia; Is It a Masked Myeloproliferative Disorder?

TGF-β1 and Serpine 1 expression changes in traumatic deep vein thrombosis

Reactive Thrombocytosis Leading to Recurrent Arterial Thrombosis Reversed by Management of a Prosthetic Joint Infection of the Hip

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