Deep venous thrombosis associated with tuberculosis

Naithani, Rahul; Agrawal, Neha; Choudhary, V.P.

doi:10.1097/mbc.0b013e3280d942b4

Cited by 38 publications

(33 citation statements)

References 23 publications

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“…Additionally, this drug may also contribute to the hypercoagulable state by decreasing production and increasing clearance of anticoagulant hepatic proteins. Consequently, the initial phase of treatment may result in a higher risk for development of DVT [19,20].…”

Section: Discussionmentioning

confidence: 99%

Association of deep venous thrombosis with pulmonary tuberculosis

Kouismi

Laine

Bourkadi

et al. 2013

Egyptian Journal of Chest Diseases and Tuberculosis

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Section: Discussionmentioning

confidence: 99%

Association of deep venous thrombosis with pulmonary tuberculosis

Kouismi

Laine

Bourkadi

et al. 2013

Egyptian Journal of Chest Diseases and Tuberculosis

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“…The associations between inflammation, hypercoagulable state, and hemostatic changes are established [4, 5]. Elevated plasma fibrinogen, impaired fibrinolysis with decreased level of antithrombin III, and reactive thrombocytosis favor development of DVT in pulmonary tuberculosis [6].…”

Section: Discussionmentioning

confidence: 99%

“…Thrombosis can also occur due to compression of the vein by lymph nodes in ganglionar form of TB as thrombosis can occur in the absence of any hemostatic abnormality [7]. Tuberculosis can cause thrombosis by various mechanisms like transitory hypercoagulable state, venous compression, and local invasion [4, 5, 7]. IJV thrombosis can occur from intracranial IJV to the junction of IJV with subclavian vein with the formation of brachiocephalic vein.…”

Section: Discussionmentioning

confidence: 99%

Internal Jugular Vein Thrombosis in Isolated Tuberculous Cervical Lymphadenopathy

Khaladkar

Chauhan

Ghosh

et al. 2016

Case Reports in Radiology

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Tuberculosis is a common infectious disease with a high prevalence in developing countries and presents a major public health issue. Internal jugular vein (IJV) thrombosis is a rare complication in tuberculous cervical lymphadenopathy. We report a case of 26-year male patient with a history of low-grade evening rise in fever, dry cough, loss of appetite, and loss of weight with swelling in lower neck on right side. Ultrasonography (USG) neck showed well-defined hypoechoic lymph nodes posterior to right IJV and common carotid artery in the lower neck at level IV and in the right supraclavicular region showing central necrotic areas with adjoining IJV thrombosis. The association between tuberculosis and deep vein thrombosis is rare. Awareness of IJV thrombosis in isolated cervical lymphadenopathy needs high diagnostic suspicion and prompt treatment to avoid fatal complication. Our case is rare as there was isolated tuberculous cervical lymphadenopathy with adjoining IJV thrombosis. Both USG and computed tomography (CT) are accurate and reliable radiological investigations for detecting IJV thrombosis along with cervical lymph nodes. They are useful in assessing surrounding soft tissue and fat planes and knowing the size and extent of cervical lymphadenopathy. USG is inexpensive and readily available for monitoring response to treatment.

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“…Hypercoagulability in tuberculosis is attributed to decreased antithrombin lll and protein C, elevated plasma fibrinogen level, increased platelet aggregation and reactive thrombocytosis [7,8]. Apart from high frequency of antiphospholipid antibody levels in a patient with tuberculosis, deficiency of protein S has been mentioned [8].…”

Section: Discussionmentioning

confidence: 99%

A rare complication of pulmonary tuberculosis: a case report

Kumarihamy¹,

Ralapanawa

Jayalath

2015

BMC Res Notes

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BackgroundPulmonary tuberculosis remains an important public health problem globally and one of the most prevalent infectious diseases in Sri Lanka. It can cause a wide variety of complications but hematological manifestations are rare. According to our literature survey, this is the first reported case of the disease associated with deep vein thrombosis in Sri Lanka.Case presentationA 37 year old Sri Lankan Sinhalese female presented with fever of one month’s duration with productive cough and two weeks painless left lower limb swelling. Chest X-ray showed bilateral inflammatory shadows with a cavitatory lesion on the right apical region. A computed tomographic pulmonary angiography scan excluded pulmonary embolism. She had rising mycoplasma antibody titre (four fold). Acute deep vein thrombosis of the left lower limb was confirmed by venous duplex. Pulmonary tuberculosis was confirmed with positive culture for Mycobacterium tuberculosis. She was treated with clarythromycin, enoxaparin, warfarin and anti tuberculus drugs. It was difficult to maintain her International Normalizing Ratio in the therapeutic range due to drug interactions and poor compliance. At five months of presentation she died of massive pulmonary embolism.ConclusionOur case emphasizes that patients with severe pulmonary tuberculosis are at risk of developing thromboembolism and superadded infections. It should be noted that even though starting anti tuberculosis drugs improved haemostatic disturbances, achieving the target International Normalizing Ratio was difficult due to drug interactions. Therefore these patients should be closely followed up to prevent complications and death from pulmonary embolism.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-015-0990-6) contains supplementary material, which is available to authorized users.

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Deep venous thrombosis associated with tuberculosis

Cited by 38 publications

References 23 publications

Association of deep venous thrombosis with pulmonary tuberculosis

Association of deep venous thrombosis with pulmonary tuberculosis

Internal Jugular Vein Thrombosis in Isolated Tuberculous Cervical Lymphadenopathy

A rare complication of pulmonary tuberculosis: a case report

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