Deep Venous Thrombosis Caused by Inferior Vena Cava Atresia and Hereditary Thrombophilia

Rose, Shelonitda S.; Ali, Yaqoob; Bekos, Teri Jo; Saidi, Parvin; Kumar, Amit

doi:10.1097/maj.0b013e31816a8d0d

Cited by 17 publications

(14 citation statements)

References 29 publications

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“…5,7,38 associated with a homozygous C677T mutation in methylenetetrahydrofolate reductase in two, 6,44 and heterozygosity in the three others among the 18 (16.7%) tested. 5,13,38 Because hyperhomocysteinemia is not considered a DVT risk factor, homocysteinemia and C677T mutation in methylenetetrahydrofolate reductase were not tested in our population. Only two (3.8%) of the 52 patients tested for antithrombin, protein C and protein S deficiencies had the latter.…”

Section: Discussionmentioning

confidence: 92%

“…8,10,12,14 A transient risk factor was found for only 10 patients: one after knee trauma, one after being bedridden for 2 days, one pregnancy with pre-eclampsia, three taking birth-control pills and four after travelling > 4 h by any means of transport (one each of our patients). 8,11,33,38,40 One patient had Behçet's disease, a disorder associated with a higher risk of venous thrombosis. A precipitating factor, mainly major physical exertion (13/63 [20.6%] patients) 8,10,12,14 could partially explain the mechanism of DVT in IVCA.…”

Section: Discussionmentioning

confidence: 99%

“…Only two (3.8%) of the 52 patients tested for antithrombin, protein C and protein S deficiencies had the latter. 8,38 Two of 41 (4.8%) tested for antiphospholipid antibodies were positive. 5,24 Because half of our 10 patients had a first-degree relative with DVT unassociated with thrombophilia, we must emphasize that IVCA does not support a genetic component and embryological dysgenesis seems to be the most commonly proposed origin.…”

Section: Discussionmentioning

confidence: 99%

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Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

et al. 2010

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Inferior vena cava agenesis (IVCA) is a rare condition, found in almost 5% of patients under 30 years old with unprovoked deep venous thrombosis (DVT). We describe 10 consecutive patients with IVCA-associated DVT and conducted an extensive literature review to investigate the typical spectrum of IVCA-associated DVT. Among our patients (eight men and two women; mean age, 25 ± 4.5 years), DVT followed intense and unusual (major) physical activity for eight of them. DVT was bilateral in six patients and unilateral in four. Ultrasonography was unable to detect IVCA, which was visualized by computed-tomography scans for seven patients, and magnetic resonance imaging and angiography for 10. Hereditary thrombophilia screening, to detect factor V Leiden or prothrombin gene heterozygosity (G20210A mutation), was positive for only two patients. Wearing elastic stockings and taking an indefinite or long-term vitamin K antagonist were prescribed for all 10 patients and nine complied with the latter. To date, 62 patients with IVCA-associated DVT have been reported in the English literature. Analysis of them and our patients yielded a typical spectrum of IVCA-associated DVT characteristics: IVCA occurs in young adults, particularly males, and is revealed by proximal DVT following major physical exertion. All were treated with a prolonged vitamin K antagonist and advised to wear elastic stockings. No precise duration of anticoagulation has been established.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

et al. 2010

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“…In the lower venous system, the most common abnormalities are interrupted or duplex IVC, presumably secondary to disrupted embryonic development of the IVC itself. [502][503][504][505][506][507][508][509] However, in the upper venous system, thoracic outlet syndrome, eponymously named Paget-Schroetter syndrome, are believed to be due to chronic trauma to the subclavian vein secondary to reduced anatomic space for the vein usually as a result of an abnormal relationship with the fi rst rib, abnormal fi brous bands or muscle development in athletes . [510][511][512][513][514][515][516][517][518][519] Management of the venous thrombosis and the underlying structural abnormality has included acute anticoagulation; both local and systemic thrombolysis through a number of techniques; percutaneous angioplasty; thrombectomy; venous reconstruction; and in the case of PagetSchroetter syndrome, decompression of the thoracic inlet through removal of relevant bone and muscle.…”

Section: Children With Vte and Structurally Abnormally Venous Systemsmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,269

559

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“…In upper limb deep vein thrombosis (80% of the total) was due to central venous catheters and malignancy [4]. Congenital IVC anomalies including inferior vena cava atresia must be considered in young patients presenting with idiopathic DVT [5]. In about 30-40% residual scar tissue is the cause of recurrent DVT.…”

Section: Recurrent Vte-causesmentioning

confidence: 99%

Recurrent Venous Thromboembolism- Its Causes, Prevention and Management

Visweshwar¹

2017

HTIJ

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Recurrent Venous Thromboembolism (VTE) is regarded a chronic disease, as it often recurs in spite of effective management with anticoagulant therapy including low molecular weight heparin, fondaparinux, warfarin and newer oral anticoagulant therapy. Patients with chronic recurrent VTE, develop other complications including post-thrombophlebitic syndrome and chronic stasis venous ulcers. The scientific data behind chronic VTE is sparse, and there are no standard guidelines for managing these patients. The financial and social burden of chronic VTE is enormous, with patients suffering with chronic pain, swelling and cramps leading to impaired activities of daily living and poor quality of life. Investigations to identify the underlying cause of chronic VTE, including inherited thrombophilia workup adds to the financial burden and does not help in the management of recurrent DVT. We will review the underlying causes of recurrent VTE its prevention and management.

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Deep Venous Thrombosis Caused by Inferior Vena Cava Atresia and Hereditary Thrombophilia

Cited by 17 publications

References 29 publications

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

Antithrombotic Therapy in Neonates and Children

Recurrent Venous Thromboembolism- Its Causes, Prevention and Management

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