Default-mode brain dysfunction in mental disorders: A systematic review

Broyd, Samantha J.; Demanuele, Charmaine; Debener, Stefan; Helps, Suzannah K.; James, Christopher J.; Sonuga‐Barke, Edmund

doi:10.1016/j.neubiorev.2008.09.002

Cited by 1,501 publications

(1,234 citation statements)

References 140 publications

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“…In our two databases the significant cross-talk appears at low frequencies (≤11 Hz), which is in line with the role of such frequencies in the long-(spatial) range co-ordination (Broyd et al 2008;Fox and Raichle 2007). In fact both networks solicit simultaneously anterior and posterior regions and more in general regions far apart several centimeters from each other (data not shown), corroborating the hypothesis that axonal transmission is at the origin of the observed interplay.…”

Section: Discussionsupporting

confidence: 88%

On the “Dependence” of “Independent” Group EEG Sources; an EEG Study on Two Large Databases

Congedo

John

Ridder³

et al. 2009

Brain Topogr

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Abstract. The aim of this work is to study the coherence profile (dependence) of robust eyes-closed resting EEG sources isolated by group blind source separation (gBSS). We employ a test-retest strategy using two large sample normative databases (N=57 and N=84). Using a BSS method in the complex Fourier domain, we show that we can rigourously study the out-of-phase dependence of the exctracted components, albeit they are extracted so as to be in-phase independent (by BSS definition). Our focus on lagged communication between components effectively yields dependence measures unbiased by volume conduction effects, which is a major concern about the validity of any dependence measures issued by EEG measurements. We are able to show the organization of the extracted components in two networks. Within each network components oscillate coherently with multiple-frequency dynamics, whereas between networks they exchange information at non-random multiple time-lag rates.

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Section: Discussionsupporting

confidence: 88%

On the “Dependence” of “Independent” Group EEG Sources; an EEG Study on Two Large Databases

Congedo

John

Ridder³

et al. 2009

Brain Topogr

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“…The method is of considerable interest for analyzing large-scale network alterations associated with specific mental states. For example, the default mode network (DMN), involving cingulate, prefrontal, parietal and temporal cortices (Broyd et al, 2009), is proposed to relate to self-absorption and rumination. In fact, FC within the DMN is increased by stress (Soares et al, 2013) and in depression (Grimm et al, 2009;Whitfield-Gabrieli and Ford, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression

et al. 2016

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Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate cortex. Alterations in network FC are associated with specific aspects of psychopathology. In mice, chronic psychosocial stress (CPS) leads to depression-relevant behavior, including increased fear learning, learned helplessness, fatigue and decreased motivation for reward. Using multimodal in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), we investigated CPS effects on function and structure in the mouse brain under light anesthesia. Mice underwent a baseline MRI/MRS session, followed by 15-day CPS (n=26) or control handling (n=27), and a post-treatment MRI/MRS session. In BOLD fMRI, relative to controls, CPS mice exhibited robust, reproducible increases in FC within 8 of 9 identified cortical networks, including the prefrontal and cingulate cortices that contribute to the "mouse DMN". CPS mice exhibited increases in between-network FC, including amygdala -prefrontal cortex and amygdala -cingulate cortex. MRS identified metabolic alterations in CPS mice as increased inositol levels in amygdala and increased glycerophosphorylcholine levels in prefrontal cortex. Diffusion-weighted MRI detected increased fractional anisotropic values in the cingulum. This study demonstrates that chronic psychosocial stress induces FC states in the mouse brain analogous to those observed in depression, as well as cerebral metabolism and white matter pathway alterations that contribute to understanding of pathological processes. It also demonstrates the importance of brain imaging to the establishment of valid animal models in translational psychiatry. AbstractHuman depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate cortex. Alterations in network FC are associated with specific aspects of psychopathology. In mice, chronic psychosocial stress (CPS) leads to depression-relevant behavior, including increased fear learning, learned helplessness, fatigue and decreased motivation for reward.Using multimodal in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), we investigated CPS effects on function and structure in the mouse brain under light anesthesia. Mice underwent a baseline MRI/MRS session, followed by 15-day CPS (n=26) or control handling (n=27), and a posttreatment MRI/MRS session. In BOLD fMRI, relative to controls, CPS mice exhibited robust, reproducible increases in FC within 8 of 9 identified cortical networks, including the prefrontal and cingulate cortices that contribute to the "mouse DMN". CPS mice exhibited increases in b...

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“…During these periods of "active rest", the DMN is thought to be involved in internal processes such as selfreferential processing, inner speech, emotional control, episodic memory, and ToM processes (Spreng et al, 2009;Wolf et al, 2011). Research has shown the constituent regions of the DMN to include the medial temporal lobe, the medial prefrontal cortex, the posterior cingulate cortex, the precuneus, and the medial, lateral, and inferior parietal cortex (Broyd et al, 2009;Spreng et al, 2009;Wolf et al, 2011). Surprisingly, though interest in the DMN is on the rise generally, and given the correspondence between the DMN functional roles and the dysfunction observed in BPD, there remains a dearth of research investigating abnormalities in DMN functioning in BPD.…”

Section: Introductionmentioning

confidence: 99%

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing. Functional coupling was analysed. Significantly decreased functional connectivity was found for patients compared with controls between anterior cingulate cortex and three brain areas involved in ToM processes: the left superior temporal lobe, right supramarginal/inferior parietal lobes, and right middle cingulate cortex. Increased functional connectivity was found in patients compared with controls between the precuneus as the DMN seed and the left inferior frontal lobe, left precentral/middle frontal, and left middle occipital/ superior parietal lobes during rest. Reduced functional coupling between the emotional and the ToM network during ToM processing is in line with emotion-regulation dysfunctions in BPD. The increased connectivity between precuneus and frontal regions during rest might be related to extensive processing of internal thoughts and self-referential information in BPD.

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Default-mode brain dysfunction in mental disorders: A systematic review

Cited by 1,501 publications

References 140 publications

On the “Dependence” of “Independent” Group EEG Sources; an EEG Study on Two Large Databases

On the “Dependence” of “Independent” Group EEG Sources; an EEG Study on Two Large Databases

Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression

Dysregulation between emotion and theory of mind networks in borderline personality disorder

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