Default mode network abnormalities in idiopathic generalized epilepsy

McGill, Megan L.; Devinsky, Orrin; Kelly, Clare; Milham, Michael P.; Castellanos, F. Xavier; Quinn, Brian T.; Dubois, Julia; Young, Jonathan R.; Carlson, Chad; French, Jacqueline A.; Kuzniecky, Ruben; Halgren, Eric; Thesen, Thomas

doi:10.1016/j.yebeh.2012.01.013

Cited by 100 publications

(108 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We also hypothesized that people with GE would have inadequate suppression of DMN during language processing expressed by abnormal task-related functional DMN segregation, in line with the recent resting-state findings by McGill et al [22]. Finally, we also hypothesized that adding complexity to the sentence reading task would induce a further reduction of the BOLD response in DMN, according to previous findings in the literature [29].…”

Section: Introductionsupporting

confidence: 77%

“…By inspection of Figure 1, we tentatively suggest that GE participants had a global deficiency to suppress DMN. Thus, a possible explanation of the result is that there is a reduced functional segregation of DMN in GE, as proposed by McGill et al [22]. This reasoning is supported by the observed significant difference between GE participants and controls in the posterior cingulate cortex, as this region is suggested to be a central node in DMN with strong interactions to other nodes of the network [47].…”

Section: Inadequate Negative Bold Responsesupporting

confidence: 54%

“…A number of studies have found decreased resting state connectivity within DMN in epilepsy patients with generalized myoclonic, tonic-clonic and/or absence seizures [22,23,24]. McGill and coworkers [22] provided evidence of abnormal functional integration and segregation of DMN in GE.…”

Section: Introductionmentioning

confidence: 99%

“…McGill and coworkers [22] provided evidence of abnormal functional integration and segregation of DMN in GE.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Gauffin¹,

Ettinger-Veenstra²,

Landtblom³

et al. 2013

Epilepsy & Behavior

View full text Add to dashboard Cite

We aimed to study the effect of a potential default mode network (DMN) dysfunction on language performance in epilepsy. Language dysfunction in focal epilepsy has previously been connected to brain damage in language associated cortical areas. In this work, we studied generalized epilepsy (GE) without focal brain damage, to see if the language function was impaired.We used functional magnetic resonance imaging (fMRI) to investigate if the DMN was involved. Eleven persons with GE and 28 healthy controls were examined with fMRI during a sentence reading task. We could demonstrate impaired language function, reduced suppression of DMN, and, specifically, an inadequate suppression of activation in the left anterior temporal lobe and the posterior cingulate cortex, as well as an aberrant activation in the right hippocampal formation. Our results highlight the presence of language decline in people with epilepsy of not only focal, but also generalized origin.

show abstract

Section: Introductionsupporting

confidence: 77%

Section: Inadequate Negative Bold Responsesupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

“…McGill and coworkers [22] provided evidence of abnormal functional integration and segregation of DMN in GE.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Gauffin¹,

Ettinger-Veenstra²,

Landtblom³

et al. 2013

Epilepsy & Behavior

View full text Add to dashboard Cite

show abstract

“…In addition to the abnormal network of epileptic foci described above, RS-fMRI studies have also found decreased functional connectivity in the attentional [53] , perceptual [54] , and default mode networks [55,56] , as well as subcortical regions [57,58] . These results indicate that abnormal synchronization is widespread in mTLE patients.…”

Section: Functional Connectivity Based On Linear Correlationmentioning

confidence: 88%

Resting-state fMRI studies in epilepsy

2012

View full text Add to dashboard Cite

Abstract:Epilepsy is a disease characterized by abnormal spontaneous activity in the brain. Resting-state functional magnetic resonance imaging (RS-fMRI) is a powerful technique for exploring this activity. With good spatial and temporal resolution, RS-fMRI is a promising approach for accurate localization of the focus of seizure activity. Although simultaneous electroencephalogram-fMRI has been performed with patients in the resting state, most studies focused on activation.This mini-review focuses on RS-fMRI alone, including its computational methods and its application to epilepsy.

show abstract

Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic‐clonic seizure

Liao

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

Network studies have demonstrated that a small set of highly connected regions may play a central role in global information integration, together forming a rich club organization. Given that generalized tonic-clonic seizure (GTCS) has been conceptualized as a network disorder, we hypothesized that the rich club disturbances may be related to the network abnormalities of GTCS. Here, we used graph theoretical analysis to investigate the rich club organization of both structural and functional connectome in patients with GTCS (n = 50) and healthy controls (n = 60). We further measured the level of global efficiency and clustering in rich club and non-rich club organization. We, respectively, identified a small number of highly connected hubs as rich club organization from structural and functional networks. Patients were found to exhibit significantly reduced rich club connectivity among the central hubs. Meanwhile, both structural and functional network showed changed levels of global efficiency and clustering of rich club organization in GTCS. Furthermore, in patients, lower levels of rich club connectivity were found to be correlated with longer duration of illness and seizure frequency. Together, these findings suggest that GTCS is characterized by a selective disruption of rich club organization due to the long-term injurious effects of epileptic actions on the central hub regions, which potentially contribute to a reduced level of brain integration capacity among different functional domains and an added effect of illness on a preexisting vulnerability. Our findings emphasize a central role for abnormal rich club organization in the pathophysiological mechanism underlying GTCS. Hum Brain Mapp 37:4487-4499, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Default mode network abnormalities in idiopathic generalized epilepsy

Cited by 100 publications

References 38 publications

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Resting-state fMRI studies in epilepsy

Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic‐clonic seizure

Contact Info

Product

Resources

About