Default mode network connectivity of fear- and anxiety-related cue and context conditioning

Zidda, Francesca; Andoh, Jamila; Pohlack, Sebastian T.; Winkelmann, Tobias; Dinu-Biringer, Ramona; Cavalli, Juliana; Ruttorf, Michaela; Nees, Frauke; Flor, Herta

doi:10.1016/j.neuroimage.2017.10.024

Cited by 30 publications

(18 citation statements)

References 66 publications

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“…However, our results do show significantly lower decreases in DMN connectivity in response to safety (CS‐) compared to threat stimuli (CS+). These results are in line with previous findings that young adults engage the DMN during safety processing (Marstaller et al, 2017; Zidda et al, 2018).…”

Section: Discussionsupporting

confidence: 93%

“…However, our results do show significantly lower decreases in DMN connectivity in response to safety (CS-) compared to threat stimuli (CS+). These results are in line with previous findings that young adults engage the DMN during safety processing (Marstaller et al, 2017;Zidda et al, 2018 (Bubic, von Cramon, & Schubotz, 2010;Hoemann, Gendron, & Barrett, 2017). In the context of threat and safety processing, the predictive framework suggests that the anticipation of affective values depends on interoceptive and visceromotor sensory predictions computed using a hierarchical, internal model of the body, which is constantly updated via the resulting prediction errors (Barrett, 2017;Barrett & Finlay, 2018;Barrett & Simmons, 2015;Kleckner et al, 2017).…”

Section: Discussionsupporting

confidence: 89%

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Salience and default‐mode network connectivity during threat and safety processing in older adults

Marstaller

Fynes-Clinton

Burianová

et al. 2020

Human Brain Mapping

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The appropriate assessment of threat and safety is important for decision-making but might be altered in old age due to neurobiological changes. The literature on threat and safety processing in older adults is sparse and it is unclear how healthy ageing affects the brain's functional networks associated with affective processing. We measured skin conductance responses as an indicator of sympathetic arousal and used functional magnetic resonance imaging and independent component analysis to compare young and older adults' functional connectivity in the default mode (DMN) and salience networks (SN) during a threat conditioning and extinction task. While our results provided evidence for differential threat processing in both groups, they also showed that functional connectivity within the SNbut not the DMNwas weaker during threat processing in older compared to young adults. This reduction of withinnetwork connectivity was accompanied by an age-related decrease in low frequency spectral power in the SN and a reduction in inter-network connectivity between the SN and DMN during threat and safety processing. Similarly, we found that skin conductance responses were generally lower in older compared to young adults. Our results are the first to demonstrate age-related changes in brain activation during aversive conditioning and suggest that the ability to adaptively filter affective information is reduced in older adults.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Salience and default‐mode network connectivity during threat and safety processing in older adults

Marstaller

Fynes-Clinton

Burianová

et al. 2020

Human Brain Mapping

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“…In adults, both positive and negative connectivity with the amygdala is typically observed in the context of threat-safety learning, with blunted connectivity related to increased differential learning indices. 82 In addition, in our adolescent sample, increased differential fear was not only associated with blunted amygdala connectivity with a circuit involving precuneus, IPL, cingulate, fusiform, and occipital regions, but also with enhanced amygdala rsFC with inferior frontal and middle temporal regions. This supports the idea that amygdala connectivity is implicated in associative learning in adults and adolescents, particularly for threat-relevant stimuli.…”

Section: Amygdala Resting-state Functional Connectivity As a Brain Me...mentioning

confidence: 53%

Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain

Timmers

López‐Solà

Heathcote

et al. 2021

Pain

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There is a need to identify brain connectivity alterations predictive of transdiagnostic processes that may confer vulnerability for affective symptomology. Here, we tested whether amygdala resting-state functional connectivity (rsFC) mediated the relationship between catastrophizing (negative threat appraisals and predicting poorer functioning) and altered threat-safety discrimination learning (critical to flexibly adapt to new and changing environments) in adolescents with persistent pain. We examined amygdala rsFC in 46 youth with chronic pain and 29 healthy peers (age M 5 15.8, SD 5 2.9; 64 females) and its relationship with catastrophizing and threat-safety learning. We used a developmentally appropriate threat-safety learning paradigm and performed amygdala seed-based rsFC and whole-brain mediation analyses. Patients exhibited enhanced connectivity between the left amygdala and right supramarginal gyrus (SMG) (cluster-level P-FDR , 0.05), whereas right amygdala rsFC showed no group differences. Only in patients, elevated catastrophizing was associated with facilitated threat-safety learning (CS1.CS2; r p 5 0.49, P 5 0.001). Furthermore, in patients, elevated catastrophizing was associated with reduced left amygdala connectivity with SMG / parietal operculum, and increased left amygdala connectivity with hippocampus, dorsal striatum, paracingulate, and motor regions (P , 0.001). In addition, blunted left amygdala rsFC with right SMG/parietal operculum mediated the association between catastrophizing and threat-safety learning (P , 0.001). To conclude, rsFC between the left amygdala (a core emotion hub) and inferior parietal lobe (involved in appraisal and integration of bodily signals and attentional reorienting) explains associations between daily-life relevant catastrophizing and threat-safety learning. Findings provide a putative model for understanding pathophysiology involved in core psychological processes that cut across diagnoses, including disabling pain, and are relevant for their etiology.

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“…The DMN contains numerous areas, including the medial frontal cortex, medial temporal lobes, inferior parietal cortex, and anterior/posterior cingulate cortex [ 8 , 12 ]. Many activities that have an awareness component are related to the DMN, such as anxiety [ 13 ], depression [ 14 ], and cognition [ 15 ]. Previous studies have identified several diseases that lead to DMN dysfunction, such as Parkinson's disease [ 16 ], Alzheimer' s disease [ 15 ], and multiple sclerosis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Regional Spontaneous Neural Activity in Nonarteritic Anterior Ischemic Optic Neuropathy: A Resting-State Functional MRI Study

Guo

Zhao

et al. 2020

Neural Plasticity

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Objective. To explore altered regional neuronal activity in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its correlation with clinical performances using the regional homogeneity (ReHo) method, which is based on resting-state functional magnetic resonance imaging (fMRI). Method. Thirty-one patients with NAION (20 males, 11 females) and 31 age- and sex-matched normal controls (NCs) (20 males, 11 females) were enrolled in the study. All patients underwent ophthalmic examination, including eyesight, intraocular pressure measurement, optimal coherence tomography (OCT), visual field analysis, and fMRI scans. After ReHo was calculated, we investigated group differences in results between the patients and NCs. We analyzed the relationship between ReHo values for different brain regions in patients with NAION and intraocular pressure, visual field analysis, and OCT. A receiver operating characteristic (ROC) curve was used to assess the diagnostic ability of the ReHo method. Results. Compared with NCs, patients with NAION exhibited higher ReHo values in the left middle frontal gyrus, left middle cingulate gyrus, left superior temporal gyrus, and left inferior parietal lobule. Additionally, they exhibited lower ReHo values in the right lingual gyrus, left putamen/lentiform nucleus, and left superior parietal lobule. ReHo values in the left superior parietal lobule were negatively correlated with right retinal nerve fiber layer values (r=−0.462, P=0.01). The area under the ROC curve for each brain region indicated that the ReHo method is a credible means of diagnosing patient with NAION. Conclusion. NAION was primarily associated with dysfunction in the default mode network, which may reflect its underlying neural mechanisms.

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Default mode network connectivity of fear- and anxiety-related cue and context conditioning

Cited by 30 publications

References 66 publications

Salience and default‐mode network connectivity during threat and safety processing in older adults

Salience and default‐mode network connectivity during threat and safety processing in older adults

Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain

Abnormal Regional Spontaneous Neural Activity in Nonarteritic Anterior Ischemic Optic Neuropathy: A Resting-State Functional MRI Study

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