We use analytical bootstrap techniques to study supersymmetric monodromy defects in the critical Wess-Zumino model. In preparation for our main result we first study two related systems which are interesting on their own: general monodromy defects (no susy), and the ε-expansion bootstrap for the Wess-Zumino model (no defects).For general monodromy defects we discuss some subtleties specific to the codimension two case. In particular, conformal blocks and the Lorentzian inversion formula have to be slightly modified in order to accommodate odd-spin operators that can have a non-zero one-point function. In the Wess-Zumino model we initiate the ε-expansion bootstrap for four-point functions of chiral operators, with the goal of obtaining spectral information about the bulk theory. We then proceed to tackle the harder technical problem of analyzing monodromy defects in the presence of supersymmetry. We use inversion formula technology and spectral data coming from our four-point function analysis, in order to completely bootstrap two-point functions of chiral operators at leading order in ε. Our result can be written in terms of novel special functions which we analyze in detail, and allows us to efficiently extract the CFT data that characterizes the correlator.