Defect Reconstruction in Articular Calcaneus Fractures with a Novel Calcium Phosphate Cement

Sarkar, Michael R.; Stahl, J.P.; Wachter, N. J.; Schwamborn, M.; Schnettler, Reinhard; Kinzl, L.

doi:10.1007/s00068-002-1179-y

Cited by 13 publications

(7 citation statements)

References 43 publications

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“…26,53,54 Recently, two European clinical studies have investigated the use of Biobon (the European equivalent of ␣-BSM) in trauma surgery and articular calcaneal fractures. 54,55 Calcaneal bone defects were filled with Biobon to augment internal fixation and were followed for 1 year. They showed that autogenous bone graft can be replaced by a resorbable calcium phosphate substitute for the use of filling bone voids and augmenting fixation.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Trial of a Bioresorbable Calcium Phosphate Paste (α-BSM) in Treatment of Displaced Intra-Articular Calcaneal Fractures

Johal

Buckley

et al. 2009

Journal of Trauma: Injury, Infection &Amp; Critical Care

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Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Trial of a Bioresorbable Calcium Phosphate Paste (α-BSM) in Treatment of Displaced Intra-Articular Calcaneal Fractures

Johal

Buckley

et al. 2009

Journal of Trauma: Injury, Infection &Amp; Critical Care

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“…Since they can be converted into hydroxyapatite (HAp) in vivo , CPCs are now highly biocompatible. Such advantages of CPCs are presented in a number of literatures 1–8. In Japan, Biopex‐R® (BPR, PENTAX, Tokyo), primarily made of α‐tricalcium phosphate (α‐TCP), was approved in the year 2000, for domestic distribution.…”

Section: Introductionmentioning

confidence: 99%

“…However, as the clinical applications of this bone cement increased, several problems have been revealed: the hardened cement is (1) shortened or crushed by loads and (2) absorbed only slightly in most of the applied area, which brings about inadequate replacement with bone 9–15. To date, more than 10 paste‐formed bone reinforcing materials have been developed worldwide 1–8. Products with high post‐setting strength are poorly absorbed and replaced with bone, while products highly absorbed and replaced with bone have lower post‐setting strength.…”

Section: Introductionmentioning

confidence: 99%

“…Such advantages of CPCs are presented in a number of literatures. [1][2][3][4][5][6][7][8] In Japan, Biopex-R 1 (BPR, PENTAX, Tokyo), primarily made of a-tricalcium phosphate (a-TCP), was approved in the year 2000, for domestic distribution. The setting time of BPR is 7.5 min, which is shorter than that of any other CPC product currently on the market.…”

Section: Introductionmentioning

confidence: 99%

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Effects of blood on bone cement made of calcium phosphate: Problems and advantages

et al. 2009

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In recent years, calcium phosphate cements (CPCs) have frequently been used as bone substitutes in the field of orthopedic surgery. When CPC is used as a bone substitute in vivo, blood contamination is unavoidable. To date, however, no detailed study has been conducted focusing on how the physical properties of CPCs would change under the influence of blood. In this study, the effects of blood contamination on Biopex-R (BPR, PENTAX, Tokyo) are examined in vitro and in vivo. The compressive strength of BPR after setting decreased depending on the amount of contaminating blood. The BPR, which has set in vivo, not only has a fragile surface due to the contamination by blood, but also has a propensity to shorten and be destroyed during the early postoperative stage, especially in the bone exposed to loads. On the other hand, radiographic and histological features in vivo indicated that the absorption and the bone replacement of BPR were stimulated by blood contamination. In the clinical evaluation, the patient's own peripheral venous blood was added to the BPR. One year after the surgery, the absorption was noted around the hardened BPR. To advance CPCs (including BPR) as bioabsorbable bone replaceable materials, it is essential to utilize the patient's own blood in combination with the CPC.

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“…Previous research on the use of BSM led to the development of a resorbable pure calcium phosphate, applicable in a paste form [20,21]. Experimental studies in animals and histological analysis in humans showed active resorption and biocompatibility confirmed by imaging techniques and histological examination [22,23,25].…”

Section: Introductionmentioning

confidence: 99%

Bone Substitution and Augmentation in Trauma Surgery with a Resorbable Calcium Phosphate Bone Cement

Bloemers

Stahl²,

Sarkar

et al. 2004

European Journal of Trauma

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Background and Purpose: Synthetically manufactured bone substitute materials are widely used to fill cancellous bone defects in fracture treatment. By using these materials, complications occurring with the harvesting of autologous bone such as inflammation, hemorrhage and pain are prevented. Ideally, after osteointegration, the bone substitute resorbs, and complete restoration of bone architecture is achieved. Until now, clinical experience is limited to non-fully resorbable calcium phosphates, e.g., hydroxyapatite. Previous studies have revealed a fully resorbable pure calcium phosphate, which is applied in a paste form as a bone implant and results in complete resorption and biocompatibility. The purpose of this prospective, uncontrolled clinical study was to investigate the safety and performance of this new resorbable bone substitute material. Patients and Methods: In 107 patients, bone defects were filled with 1.0-27.5 g (median 5.45 g) of the bone substitute material. From 15 patients, biopsy samples for histological examination could be taken during secondary surgery, mostly when implants for osteosynthesis had to be removed. Results: On clinical, radiologic and histological examination, the bone substitute material studied appeared safe and efficient for filling bone defects in fracture treatment, showing resorption and osseous integration during remodeling of bone. No clinical signs of allergic reactions or inflammation did occur. Conclusion: When using calcium phosphate bone cement, a second surgical procedure to harvest autologous bone is not necessary and complications at the donor site are avoided.

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Defect Reconstruction in Articular Calcaneus Fractures with a Novel Calcium Phosphate Cement

Cited by 13 publications

References 43 publications

A Prospective Randomized Controlled Trial of a Bioresorbable Calcium Phosphate Paste (α-BSM) in Treatment of Displaced Intra-Articular Calcaneal Fractures

A Prospective Randomized Controlled Trial of a Bioresorbable Calcium Phosphate Paste (α-BSM) in Treatment of Displaced Intra-Articular Calcaneal Fractures

Effects of blood on bone cement made of calcium phosphate: Problems and advantages

Bone Substitution and Augmentation in Trauma Surgery with a Resorbable Calcium Phosphate Bone Cement

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