1992
DOI: 10.1016/s0022-2275(20)41507-x
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Defective catabolism of oxidized LDL by J774 murine macrophages.

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Cited by 55 publications
(13 citation statements)
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“…If LDL lipid hydroperoxides were to accumulate in intracellular compartments after endocytosis, they could impair intracellular metabolism. Cellular catabolism of apoB of extensively copper-oxidized LDL is known to be inefficient (58)(59)(60), and although this is probably secondary to modification of apoB occurring during oxidation, under some circumstances there may be inactivation of lysosomal proteases (61). The observation that lipid hydroperoxides appear to directly inhibit neutral and acidic cholesteryl ester hydrolase activity ( 62) is concordant with our observations on the impaired clearance of lipoproteinderived, unoxidized CE in cells loaded by incubation with OxAcLDL.…”
Section: Discussionsupporting
confidence: 84%
“…If LDL lipid hydroperoxides were to accumulate in intracellular compartments after endocytosis, they could impair intracellular metabolism. Cellular catabolism of apoB of extensively copper-oxidized LDL is known to be inefficient (58)(59)(60), and although this is probably secondary to modification of apoB occurring during oxidation, under some circumstances there may be inactivation of lysosomal proteases (61). The observation that lipid hydroperoxides appear to directly inhibit neutral and acidic cholesteryl ester hydrolase activity ( 62) is concordant with our observations on the impaired clearance of lipoproteinderived, unoxidized CE in cells loaded by incubation with OxAcLDL.…”
Section: Discussionsupporting
confidence: 84%
“…The correlation coefficient was 0.96. (31,32). These findings suggest an accumulation of lipoprotein components within lysosomes.…”
Section: Discussionmentioning
confidence: 72%
“…Another reported difference in metabolism of the two particles is that the protein moiety of oxLDL is hydrolyzed at a much slower rate than that of acLDL (18)(19)(20). In addition, immunolocalization and ultrastructural studies suggest that oxLDL accumulates in the lysosomes of both cultured macrophages and human atherosclerotic tissues (20,21), and more recent studies have demonstrated a buildup of oxLDL free cholesterol in the lysosomes of J774 macrophages. From this and other data, it has been postulated that degradation of the entire oxLDL particle could be arrested in the lysosome (18).…”
mentioning
confidence: 99%