Defective Collagen Metabolism in Saudi Patients with Hernia

Ajabnoor, Mohammad A. M.; Mokhtar, Ahmed; Rafee, Adel A; Taha, Ahmed

doi:10.1177/000456329202900411

Cited by 46 publications

(37 citation statements)

References 11 publications

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“…All studies recognize the role of the collagen in attributing structural resistance and integrity to the aponeurosis and fascias (2) . In this condition the presence in adequate amount as well as the collagen properties are essential for the functionality of fascia transversalis.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Meyer¹,

Berger²,

Monteiro³

et al. 2007

Arq. Gastroenterol.

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-Background -Inguinal hernia is the second most common surgical case in our field. The anatomical factors alone are not enough to explain the inguinal hernia. Studies show changes in the proportion and quantity of collagen fibers in the developing of inguinal hernia. The greater production of collagen type III compared to the type I could justify the thinning of the fascia transversalis and its weakness. Aim -To determine the quantitative and qualitative changes of collagen in the fascia transversalis in inguinal hernia patients and compare them to findings from corpses without inguinal hernia. Method -Prospective case-control study based on the biopsy of fascia transversalis of 27 patients and 24 corpses. The technique used was hematoxylin-eosin and picrosirius colorimetry. Results -The medium percent area of collagen (types I + III) and collagen type I, in both groups, show no statistic difference. The quantity of collagen type III was greater in the patients. Patients classified with Nyhus IIIa presented greater quantity of collagen type III. Conclusion -There is no significant difference in the quantity of collagen in the fascia transversalis of patients compared to the controls. An increase in the quantity of collagen type III was found in patients with inguinal hernia and a greater quantity in those patients classified with Nyhus IIIa. HEADINGS -Hernia, inguinal. Fascia. Collagen.

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Section: Introductionmentioning

confidence: 99%

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Meyer¹,

Berger²,

Monteiro³

et al. 2007

Arq. Gastroenterol.

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“…Research aimed at evaluating the role played by biologic factors has centered on possible alterations in connective tissue metabolism. This idea is also supported by the fact that diseases such as Marfan and Ehlers-Danlos syndromes, cutis laxa, osteogenesis imperfecta, 3 and congenital hip dislocation 4 have been associated with hernial processes.Tissue specimens from patients with hernias for this type of experimental study include the abdominal anterior rectus muscle sheath, 5 cremaster, hernial sac, 6 and even skin tis- …”

mentioning

confidence: 99%

Fibroblasts From the Transversalis Fascia of Young Patients With Direct Inguinal Hernias Show Constitutive MMP-2 Overexpression

et al. 2001

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ObjectiveTo determine the expression pattern of certain metalloproteinases (MMPs) known to be involved in the degradation of the extracellular matrix in cultured fibroblasts from the transversalis fascia (TF) of patients with inguinal hernia. Summary Background DataInguinal hernia is a common pathology, the cause of which remains unknown. It is, however, clear that the TF is one of the anatomical structures that may impede the formation of hernias, and particularly the direct type of hernia. In previous studies the authors found enhanced MMP-2 expression in TF specimens in vivo. The persistence of increased expression in cultured fibroblasts might support the idea of a genetic defect as the cause for this pathology. MethodsFibroblasts from the TF of patients with direct and indirect inguinal hernia were cultured and compared with those obtained from control TF in terms of MMP (MMP-2 and MMP-9) expression. ResultsSignificant active MMP-2 expression was shown by TF fibroblasts from young patients with direct hernias. These findings were confirmed by immunosorbent assay, immunoblotting, and zymography of the fibroblast culture media. No MMP-9 expression was detected. ConclusionThese results indicate that MMP-2 may be involved in the TF matrix degradative process in patients with direct hernia. The persistence of changes in MMP-2 levels in the cell cultures appears to suggest a genetic defect or irreversible change as the origin of this pathology rather than environmental factors, which may later participate in the development of the hernial process.Inguinal hernias are among the disorders that most frequently require surgery: their repair accounts for 10% to 15% of all general surgical procedures.1 Although the cause remains unknown, it has been established that the integrity of the abdominal wall in the groin area is dependent on the transversalis fascia (TF), the oblique orientation of the inguinal canal, and a sphincterlike structure of the internal ring. 2Despite numerous predisposing factors, including anatomical features (persistence of the peritoneal-vaginal conduit, high insertion point of the transverse arch) and those associated with other diseases (obesity, chronic obstructive pulmonary disease, constipation), the underlying cause of the development of the different types of hernias is of a biologic nature. Research aimed at evaluating the role played by biologic factors has centered on possible alterations in connective tissue metabolism. This idea is also supported by the fact that diseases such as Marfan and Ehlers-Danlos syndromes, cutis laxa, osteogenesis imperfecta, 3 and congenital hip dislocation 4 have been associated with hernial processes.Tissue specimens from patients with hernias for this type of experimental study include the abdominal anterior rectus muscle sheath, 5 cremaster, hernial sac, 6 and even skin tis-

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“…Patients with inguinal hernia have been shown to have a defective collagen synthesis mechanism coupled with changes in the ratios of the types of collagen. This renders the abdominal sinews weaker, making them more prone to hernias (Ajabnoor et al 1992, Rosch et al 2002, Tharappel 2014, Wagh & Read 1972.…”

Section: Possible Mechanism Of Action Of Some Of the Plants Used To Tmentioning

confidence: 99%

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

Kibuuka

Anywar

2015

Ethnobot. Res. App.

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Defective Collagen Metabolism in Saudi Patients with Hernia

Cited by 46 publications

References 11 publications

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Fibroblasts From the Transversalis Fascia of Young Patients With Direct Inguinal Hernias Show Constitutive MMP-2 Overexpression

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

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