Defective development and reproductive wastage in the United States

Stickle, G

doi:10.1016/s0002-9378(15)33712-1

Cited by 26 publications

(5 citation statements)

References 4 publications

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“…The percentage of pregnancies that terminate spontaneously before 20 weeks of gestation in the general population is 26.9% to 28.6%. 22,23 The percentage of pregnancies, reported by our patients, that terminated before 20 weeks was within this range. However, recall of events that may represent a spontaneous abortion is inaccurate.…”

Section: Acute Lymphoblastic Leukemiasupporting

confidence: 80%

Pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence

Green

Hall

Zevon

1989

Cancer

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To evaluate gonadal function and pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence, 44 former patients who were less than 20 years of age at diagnosis, 5 or more years from diagnosis, and 18 or more years of age were contacted. Thirty-nine (88%) provided information regarding pregnancy outcome. Gonadal function as estimated by the ability to conceive or sire a pregnancy, was not impaired despite treatment with substantial cumulative doses of methotrexate, 6-mercaptopurine, vincristine, and 1-asparaginase. Twelve patients reported a total of 27 pregnancies. There were four spontaneous abortions, one stillborn, and 22 liveborn infants. The birthweights were 1928 to 4536 g (median, 3430 g). Two infants had congenital anomalies. The childrens' ages ranged from 1 month to 10 years, 2 months (median, 6 years, 1 month). None has been diagnosed with any type of childhood cancer. The results of this study suggest that pregnancy outcome is not affected adversely by treatment received during childhood or adolescence for acute lymphoblastic leukemia.

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Section: Acute Lymphoblastic Leukemiasupporting

confidence: 80%

Pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence

Green

Hall

Zevon

1989

Cancer

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“…13 There is a possibility that the reported incidence of miscarriage underestimates the actual rate, since successful pregnancies are more likely to be reported, and recall of events representing a spontaneous abortion have been found to be inaccurate; 32 approximately one in five pregnancies as detected by human chorionic gonadotropin assay are clinically unrecognized. 33 Pre-term labor and delivery may result from preeclampsia, multiple gestation, intrauterine infection and distortion of the uterine cavity due to a variety of reasons. Irradiation has been shown to reduce the elasticity of the uterine musculature, probably secondary to intrauterine vascular damage.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the bone marrow transplant survivor study

Carter

Robison

Francisco

et al. 2006

Bone Marrow Transplant

142

118

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“…Thus from conception to birth, the incidence of chromosome abnormalities declines by as much as 100-fold. The majority (Ͼ95%) of losses occur in the first trimester either as spontaneous abortions [4] or earlier lack of cleavage and/or lack of implantation [5,6]. Seminal works in the early 1960s demonstrated the significance of chromosome abnormalities in spontaneous abortions [7,8].…”

Section: Introductionmentioning

confidence: 99%

Chromosome abnormalities in the placenta and spontaneous abortions

Qumsiyeh

1998

J. Matern. Fetal Med.

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Data are presented confirming that placental chromosome abnormalities are more important than fetal chromosome abnormalities in determining fetal loss. Improved methodologies for studying chromosome abnormalities in spontaneous abortion (SAB) are presented that include results for 141 cases (gestational ages 6–24 weeks) with karyotypic study on placental as well as fetal tissue. Experience in two laboratories gave a success rate of >90% of specimens with identifiable placental tissues, an average turnaround time of 10 days for those that produced chromosome results, male‐to‐female ratio of >50% (indicating no impact of maternal cell contamination), and 30% of cases had chromosome abnormalities. More significantly, two cases (5% of all abnormal cases) showed an abnormal karyotype limited to the placenta. This illustrates the need to examine the placenta in cases of SAB and the importance of technical issues in laboratory studies. J. Matern.–Fetal Med. 7:210–212, 1998. © 1998 Wiley‐Liss, Inc.

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Defective development and reproductive wastage in the United States

Cited by 26 publications

References 4 publications

Pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence

Pregnancy outcome after treatment for acute lymphoblastic leukemia during childhood or adolescence

Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the bone marrow transplant survivor study

Chromosome abnormalities in the placenta and spontaneous abortions

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