Defective human T‐lymphotrophic virus type I provirus in T‐cell prolymphocytic leukaemia

Kojima, Kensuke; Sawada, Takashi; Ikezoe, Takayuki; Matsuo, Yoshinobu; Kobayashi, Hajime; Yano, Tomonori; Sugimoto, Takeshi; Imoto, Shion; Nakagawa, Toshio; Matsui, Toshimitsu; Yasukawa, Masaki; Hara, Masamichi; Taguchi, Hirokuni

doi:10.1111/j.1365-2141.1999.01329.x

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…The deletion would eliminate the donor sites for the mRNAs of the proteins encoded by the tax gene [14], and, indeed, serum levels of C-PTHrP in the two cases were not elevated (28.7 and 35.4 pmol/l). Normal serum C-PTHrP levels in these cases were in agreement with the previous findings of no tax gene expression in cases with the sequence [10]. In contrast to ATL, in which various serum markers provide useful therapeutic and prognostic information, it is not known whether serum parameters have valuable clinical information for patients with T-PLL.…”

Section: Discussionsupporting

confidence: 88%

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Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia

et al. 1999

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T-cell prolymphocytic leukemia (T-PLL) is a rare post-thymic T-cell neoplasm which shares most clinical features with adult T-cell leukemia (ATL). We measured serum level of C-terminal parathyroid hormone-related protein (C-PTHrP) in patients with T-PLL and ATL. Serum C-PTHrP levels of eight patients with T-PLL (median 36.8 pmol/l; range 27.0-50.2 pmol/l) did not differ from those of 30 human T-lymphotropic virus type I (HTLV-I)-seronegative blood donors (median 37.0 pmol/l; range 22.6-54.0 pmol/l). The C-PTHrP levels in ten ATL patients (median 69.6 pmol/l; range 42.5-899.4 pmol/l) were significantly higher than those in healthy controls (p<0.0001) or T-PLL patients (p=0.001). We suggest that the serum level of PTHrP can provide useful information for differentiating between T-PLL and ATL.

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Section: Discussionsupporting

confidence: 88%

“…Patients with T-PLL are commonly seronegative for HTLV-I and have no functionally active proviral HTLV-I DNA in their leukemia cells [10,11]. Hypercalcemia does not develop in patients with T-PLL.…”

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confidence: 98%

Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia

et al. 1999

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“…Moreover, findings about seronegative HTLV-1 carriers have been described in groups of TSP/HAM patients from different countries, 3,5 in HTLV-1 infected patients with MF 10,11 and their relatives 11 in addition to subjects with ID 7 or hematological diseases. [20][21][22] This is the first report of seronegative profiles in symptomatic and asymptomatic HTLV-1 infected subjects in Argentina. Our results indicate that prevalence rates of HTLV-1/2 infection settled down by serology could be underestimated and corroborate the strong silent dissemination of HTLV-1 infection in Northern Argentina, as we have previously reported.…”

Section: Discussionmentioning

confidence: 79%

First Description of Seronegative HTLV-1 Carriers in Argentina

Gallego

Frutos

Blanco

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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In some areas of Argentina endemic for human T-lymphotropic virus type 1 (HTLV-1), tropical spastic paraparesis is frequent in subjects who lack antibodies against the virus; however, the relevance of this seronegative status in the country has not been investigated. In neighboring countries, HTLV-1 seronegative status has been described in patients with different diseases; however, data regarding features of seronegative HTLV-1 carriers are scarce. We investigated the seronegative status in 124 relatives of 28 HTLV-1 infected subjects from an endemic area in Northwest Argentina. Blood samples and clinical/epidemiological data were collected. Human T-lymphotropic virus type 1 infection was diagnosed by serology and long terminal repeat (LTR) sequence, env and tax gene detection. IgG anti-Tax HTLV-1 antibody, tax gene sequence, and DNA proviral load were also evaluated. Seventy-five percent of the 124 relatives were negative for HTLV-1/2 antibodies; 35.5% were also negative by molecular assays and 64.5% were negative for HTLV-1 LTR and env sequences, but positive for two sequences of HTLV-1 tax gene. Also, 35.7% of these subjects had IgG anti-Tax antibodies. The seronegative HTLV-1 status was significantly associated with male gender, youth, and sensory symptoms/autonomic nervous system dysfunction. High rates of seronegative symptomatic and asymptomatic HTLV-1 carriers in Argentina are described. The evidence highlights that HTLV-1 prevalence may be underestimated worldwide. Larger cohort studies are required to assess disease outcome in these seronegative subjects. Also, the findings emphasize the limitations of ongoing screening assays for diagnosis and blood safety. Therefore, algorithms for HTLV-1 diagnosis should include not only serological but also molecular assays.

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“…However, we were unable to detect antibodies in the patient's serum, perhaps as a result of severe immunosuppression owing to the long-standing disease and adverse effects of the prolonged chemotherapy. Seronegativity of patients infected with HTLV-1 has been reported previously [16,36] and often related to defective viral genome [13,24] and to suboptimal levels of HTLV-1 for antibody responses [17]. Additionally, it has been suggested that HTLV-1 might play a role in the induction of severe immunosuppression and high rate of infections by altering T lymphocyte immune function [2,18,22].…”

Section: Discussionmentioning

confidence: 98%

Human T lymphotropic virus type 1 in a seronegative B chronic lymphocytic leukemia patient

Stark

Bodemer

Hannig

et al. 2003

Medical Microbiology and Immunology

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Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 infection in patients with B cell-type chronic lymphocytic leukemia (B-CLL) is rare and has been reported only in areas in which HTLV-1 is endemic. In the present study, we detected HTLV-1 proviral DNA by polymerase chain reaction, using tax primers, in peripheral blood lymphocytes from a B-CLL patient, an immigrant to Israel, where HTLV-1 infection is not endemic. F344 rats injected intravenously with peripheral blood lymphocytes obtained from the patient developed HTLV-1 antibodies. Titers of antibody to HTLV-1 in the rat blood were 1:512 by particle agglutination; enzyme-linked immunosorbent assay and Western blotting were also positive. No antibody against HTLV-1 was demonstrated in the animal model after inoculation of either purified B lymphocytes from the B-CLL patient or peripheral blood mononuclear cells from healthy donors. This is one of the few studies showing the presence of HTLV-1 provirus in T lymphocytes of a B-CLL patient who had multiple infections, and died of salmonella sepsis, and the first report of HTLV-1 antibody induction in an animal model by inoculation of lymphocytes obtained from an HTLV-1-infected B-CLL patient.

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Defective human T‐lymphotrophic virus type I provirus in T‐cell prolymphocytic leukaemia

Cited by 7 publications

References 32 publications

Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia

Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia

First Description of Seronegative HTLV-1 Carriers in Argentina

Human T lymphotropic virus type 1 in a seronegative B chronic lymphocytic leukemia patient

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