2020
DOI: 10.1101/2020.01.30.928051
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Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

Abstract: ABSTRACTInfluenza A virus (IAV) increases presentation of class I human leukocyte antigen (HLA) proteins that limit antiviral responses mediated by natural killer (NK) cells, but molecular mechanisms have not yet been fully elucidated. We observed that infection with A/Fort Monmouth/1/1947 (H1N1) IAV significantly increased presentation of HLA-B, -C and -E on lung epithelial cells. Virus entry was not sufficient to induce HLA upregulation, because UV-inactivated virus had no ef… Show more

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“…Mammalian cells were grown in DMEM supplemented with 10% FBS: 293T, ♀; A549, ♂; MDBK, ĵ; MDCK, ♂. Innate sensing A549 knockout cells were a kind gift from C. McCormick and described previously (Rahim et al, 2020). All cells were maintained at 37 °C, 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…Mammalian cells were grown in DMEM supplemented with 10% FBS: 293T, ♀; A549, ♂; MDBK, ĵ; MDCK, ♂. Innate sensing A549 knockout cells were a kind gift from C. McCormick and described previously (Rahim et al, 2020). All cells were maintained at 37 °C, 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%