Defective innate immune responses to respiratory syncytial virus infection in ovalbumin-sensitized mice

Lai, Siang Hui; Liao, Sui‐Ling; Wong, Kin Sun; Lin, Tzou Yien

doi:10.1016/j.jmii.2014.09.001

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Acute Damage and Early Immune Response Against Hrsv In The A1

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“…Also, production of IFN-a is significantly lower in infants as compared to adults, which may contribute to the increased susceptibility of infants and young children to suffering severe hRSV disease [29]. Furthermore, a reduction in type I IFNs was associated to an increase of hRSV loads in lungs [26,30]. In addition, the production of pro-inflammatory cytokines was abrogated in the lungs and bronchoalveolar fluid of IFNAR1 À/À mice upon hRSV infection [26].…”

Section: Acute Damage and Early Immune Response Against Hrsv In The Amentioning

confidence: 99%

Inflammatory damage on respiratory and nervous systems due to hRSV infection

Böhmwald¹,

Espinoza²,

Becerra³

et al. 2015

Current Opinion in Immunology

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Section: Acute Damage and Early Immune Response Against Hrsv In The Amentioning

confidence: 99%

Inflammatory damage on respiratory and nervous systems due to hRSV infection

Böhmwald¹,

Espinoza²,

Becerra³

et al. 2015

Current Opinion in Immunology

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Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: where are we now?

et al. 2017

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Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role in asthma exacerbation. We also review recent advances made in animal models to determine immune responses following hMPV infection, and compare to what is known about RSV.

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