Defective Neutrophil Chemotactic Responses in Patients With Recurrent Episodes of Otitis Media and Chronic Diarrhea

Hill, Harry R.; Book, Linda S.; Hemming, Val G.; Herbst, John J.

doi:10.1001/archpedi.1977.02120170059011

Cited by 18 publications

(6 citation statements)

References 22 publications

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“…Neutrophils have traditionally been considered to play a protective role in OM (12,13). However, recent studies have speculated that neutrophils may contribute to bacterial persistence in the middle ear via the formation of neutrophil extracellular traps (NETs) (14)(15)(16).…”

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confidence: 99%

Antibodies Mediate Formation of Neutrophil Extracellular Traps in the Middle Ear and Facilitate Secondary Pneumococcal Otitis Media

et al. 2014

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g Otitis media (OM) (a middle ear infection) is a common childhood illness that can leave some children with permanent hearing loss. OM can arise following infection with a variety of different pathogens, including a coinfection with influenza A virus (IAV) and Streptococcus pneumoniae (the pneumococcus). We and others have demonstrated that coinfection with IAV facilitates the replication of pneumococci in the middle ear. Specifically, we used a mouse model of OM to show that IAV facilitates the outgrowth of S. pneumoniae in the middle ear by inducing middle ear inflammation. Here, we seek to understand how the host inflammatory response facilitates bacterial outgrowth in the middle ear. Using B cell-deficient infant mice, we show that antibodies play a crucial role in facilitating pneumococcal replication. We subsequently show that this is due to antibody-dependent neutrophil extracellular trap (NET) formation in the middle ear, which, instead of clearing the infection, allows the bacteria to replicate. We further demonstrate the importance of these NETs as a potential therapeutic target through the transtympanic administration of a DNase, which effectively reduces the bacterial load in the middle ear. Taken together, these data provide novel insight into how pneumococci are able to replicate in the middle ear cavity and induce disease.

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confidence: 99%

Antibodies Mediate Formation of Neutrophil Extracellular Traps in the Middle Ear and Facilitate Secondary Pneumococcal Otitis Media

et al. 2014

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“…Defective humoral immunity in children with OME was already noticed [5]. Alteration of neutrophil chemotactic responses has been reported in patients with chronic otitis [26].…”

Section: Discussionmentioning

confidence: 95%

Alteration of adenoid tissue alkaline and acid phosphatase in children with secretory otitis media

Jesić¹,

Stojiljković

Petrović³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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“…The migration of PMN into the middle ear when purulent otitis media occurs suggests that PMN play an important role in the immune response to bacterial infection of the middle ear. Hill et al described 14 children with recurrent otitis media and chronic diarrhea in association with markedly abnormal PMN chemotactic activity (19).…”

Section: Discussionmentioning

confidence: 99%

Influenza A virus-induced polymorphonuclear leukocyte dysfunction in the pathogenesis of experimental pneumococcal otitis media

Abramson¹,

Giebink²,

Quie³

1982

Infect Immun

109

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The role of influenza A virus-induced polymorphonuclear leukocyte and eustachian tube dysfunction in the pathogenesis of acute purulent otitis media was studied in chinchillas. Polymorphonuclear leukocyte function, middle ear pressure, and the incidence of pneumococcal otitis media were observed after intranasal inoculation with influenza A virus, Streptococcus pneumoniae, or both. Results showed that depressed negative middle ear pressure and polymorphonuclear leukocyte chemiluminescence and chemotactic activity occurred after influenza inoculation, but not after inoculation with pneumococcus alone. The greatest incidence of pneumococcal otitis media occurred when the pneumococcus was inoculated just before the time of influenza-induced polymorphonuclear leukocyte dysfunction and negative middle ear pressure. Animals that had unilateral tympanostomy tubes placed before inoculation of influenza with pneumococcus showed no difference in the occurrence of pneumococcal otitis media in ventilated and nonventilated ears, suggesting that polymorphonuclear leukocyte dysfunction contributes more to the pathogenesis of pneumococcal otitis media than does negative middle ear pressure in this animal model.

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Defective Neutrophil Chemotactic Responses in Patients With Recurrent Episodes of Otitis Media and Chronic Diarrhea

Cited by 18 publications

References 22 publications

Antibodies Mediate Formation of Neutrophil Extracellular Traps in the Middle Ear and Facilitate Secondary Pneumococcal Otitis Media

Antibodies Mediate Formation of Neutrophil Extracellular Traps in the Middle Ear and Facilitate Secondary Pneumococcal Otitis Media

Alteration of adenoid tissue alkaline and acid phosphatase in children with secretory otitis media

Influenza A virus-induced polymorphonuclear leukocyte dysfunction in the pathogenesis of experimental pneumococcal otitis media

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