Defective S‐TiO_2−x/CeO₂ Heterojunction for Mutual Reinforcing Chemodynamic/Sonocatalytic Antibacterial Therapy and Sonoelectric/Ion‐Activated Bone Regeneration

Abstract

Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role in sonocatalysis and chemodynamics, and how to regulate electron transfer and achieve mutual‐reinforcement between sonocatalysis and chemodynamic to achieve efficient antibacterial therapy is a difficult problem. Here, this study develops a defective S‐doped TiO2 and CeO2 heterojunction(S‐TiO2−x/CeO2）sonosensitizer that can enhance chemodynamic therapy by regulating valence transitions of CeIII/CeIV by sonoelectrons, and enhancing sonocatalytic therapy by creating heterojunctions to accelerate the transfer of interface electron, thereby achieving mutual reinforcement of sonocatalysis and chemodynamic. It could kill 99.3% of S. aureus under ultrasound (US) irradiation . Due to the presence of mixed valence states CeIII/CeIV in CeO2, S‐TiO2−x/CeO2 could be as oxy‐substrates. Ce4+ can deplete glutathione and reacts with H2O2 in bacteria to produce reactive oxygen species (ROS). These activities combines with ROS generated from sonocatalysis, resulting in bacterial death. Meanwhile, the electrical signal generated by S‐TiO2−x/CeO2 under US stimulation and the cerium ions could activate the Wnt/β‐catenin signaling pathway to induce hBMSCs to differentiate into osteoblast. S‐TiO2−x/CeO2 successfully treats osteomyelitis under US irradiation by effectively clearing infection, suppressing inflammatory, and promoting bone regeneration, and it provides effective treatment for patients with deep infection.

Photo-sono activated BNT@MoS2 composites for rapid eradication of breast cancer

“…The scanning frequency and scanning area are 0.5 Hz and 2 μm, respectively. The ESR spectrometer (EMXPLUS10/12, Bruker, Germany) was used to text ESR, and the ultrasonic parameters used in the experiment were 1.0 MHz, 1.5 W/cm 2 , 50 % duty cycle [ 13 , 14 ].…”

Shear Flow-Assembled Janus Membrane with Bifunctional Osteogenic and Antibacterial Effects for Guided Bone Regeneration

“…Bone repair, a complex multifactorial process, is crucial for skeletal system health. − Guided bone regeneration (GBR) membranes that reside at the interface between the bone and surrounding soft tissues have attracted increasing attention in bone repair and regeneration. , GBR membranes can serve as a barrier to prevent the invasion of soft tissue cells into the bone defect while promoting osteogenic differentiation. − Recent research efforts about GBR membranes have focused on the enhancement of osteogenic differentiation and antibacterial effects. For instance, Bottino and collaborators doped β-tricalcium phosphate to fabricate a GBR membrane with a uniform porous network, which increased cell attachment, proliferation, mineralization, and osteogenic gene expression .…”

Nanomedical Sonocatalyst Tailored for Enhanced Hypoxic Tumor Therapy Based on Crystal Facet Engineering Strategy

“…14,15 Hence, improving the catalytic activity of sonocatalysts to enable outstanding therapeutic efficacy within safe doses remains a formidable challenge. 16 To resolve this conundrum, a variety of semiconductor nanomaterials as sonocatalysts have been developed and introduced into SCT, such as metal oxides, 17,18 metal carbides, 19 metal nitrides, 20 metal sulfides, 21,22 and others. Despite the advancements achieved through these endeavors, most of research has focused on screening and optimizing catalysts by the means of introducing defects and regulating electronic structures while ignoring the impact of the surface structure of the catalyst on the catalytic behavior.…”

“…As a typical representative of this novel catalytic therapy, sonocatalytic therapy (SCT) has made rapid progress in the field of nanomedicine because of its high operability and strong tissue penetration. , However, the further clinical transformation of SCT is still restricted by rapid recombination of ultrasound (US)-induced charge and insufficient active sites. , Hence, improving the catalytic activity of sonocatalysts to enable outstanding therapeutic efficacy within safe doses remains a formidable challenge . To resolve this conundrum, a variety of semiconductor nanomaterials as sonocatalysts have been developed and introduced into SCT, such as metal oxides, , metal carbides, metal nitrides, metal sulfides, , and others. Despite the advancements achieved through these endeavors, most of research has focused on screening and optimizing catalysts by the means of introducing defects and regulating electronic structures while ignoring the impact of the surface structure of the catalyst on the catalytic behavior. , Generally, both substrate adsorption and further conversion occur on the catalyst surface .…”