Defects of immune surveillance offer new insights into the pathophysiology and therapy of myelodysplastic syndromes

Kiladjian, Jean‐Jacques; Fenaux, Pierre; Caignard, Anne

doi:10.1038/sj.leu.2404868

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…In addition, a protective effect of coffee consumption on the risk of developing malignancy might also be related to the inhibition of oxidative stress, regulation of DNA repair, apoptosis and inflammation . Recent studies suggested that escape of immune surveillance by innate and adaptive immune system may be crucial for the development of MDS . Enhanced immune surveillance by coffee might contribute to the protective effect on the risk of MDS.…”

Section: Discussionmentioning

confidence: 99%

“…8 Recent studies suggested that escape of immune surveillance by innate and adaptive immune system may be crucial for the development of MDS. 26,27 Enhanced immune surveillance by coffee might contribute to the protective effect on the risk of MDS. Furthermore, green tea did not show a protective effect against MDS in the present analysis.…”

Section: Significant Association Between Coffee Consumption and The Rmentioning

confidence: 99%

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Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Ugai

Matsuo

Sawada³

et al. 2017

Intl Journal of Cancer

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Although coffee and green tea are suggested to reduce the risk of some types of cancers, only a few epidemiological studies have investigated their effect on the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, we investigated the association of coffee and green tea consumption and the risk of AML and MDS in a large-scale population-based cohort study in Japan. A total of 95,807 Japanese subjects (45,937 men and 49,870 women; age 40-69 years at baseline) were followed to the end of 2012, for an average of 18 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between coffee and green tea consumption at baseline and the risk of AML and MDS were assessed using a Cox proportional hazards model with adjustment for potential confounders. During 1,751.956 person-years, we identified 85 AML cases and 70 MDS cases. Our findings showed no significant association between coffee consumption and the risk of AML, or between green tea consumption and the risk of AML or MDS. In contrast, we observed a decreasing dose-response relationship between coffee consumption and the risk of MDS among men (almost none: reference, 1-4 times/week: HR = 0.83, 95% CI: 0.43-1.62; ≥1cups/day: HR = 0.47, 0.22-0.99, p for trend = 0.049). Stratified analysis by smoking status suggested that the observed relative risk for AML and MDS of coffee drinkers relative to non-coffee drinkers might be due to residual confounding by smoking. These findings deserve further investigation in future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Significant Association Between Coffee Consumption and The Rmentioning

confidence: 99%

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Ugai

Matsuo

Sawada³

et al. 2017

Intl Journal of Cancer

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“…Confirmation of these defects can open new perspectives in immunotherapy in the treatment of MDS (Kiladjian et al, 2007). Confirmation of these defects can open new perspectives in immunotherapy in the treatment of MDS (Kiladjian et al, 2007).…”

Section: Nk Cells In Myelodysplasiamentioning

confidence: 91%

“…NKG2D expression was normal or low (Epling-Burnette et al, 2007). However, these studies used PBMC that were not confirmed in another study using purified NK cells (Kiladjian et al, 2006(Kiladjian et al, , 2007. Decreased NK cytolytic function could be correlated with high risk myelodysplasia (Epling-Burnette et al, 2007).…”

Section: Nk Cells In Myelodysplasiamentioning

confidence: 94%

Natural killer cells in leukaemia

Rey¹,

Fauriat²,

Moretta³

et al. 2010

Natural Killer Cells

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“…In MDS, NK cell number is usually not reduced as compared to healthy donors ( 50 , 51 ) although it can be low in as much as 20% of patients, independently of T lymphopenia. NK deficiency is directly related to a MDS with poor prognosis such as refractory anemia with excess blasts ( 52 ).…”

Section: Defect In Immuno Surveillance Favors Mdsmentioning

confidence: 99%

Bone Marrow Immunity and Myelodysplasia

Lambert¹,

Aanei

2016

Front. Oncol.

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Myelodysplastic syndrome (MDS) is characterized by an ineffective hematopoiesis with production of aberrant clones and a high cell apoptosis rate in bone marrow (BM). Macrophages are in charge of phagocytosis. Innate Immune cells and specific T cells are in charge of immunosurveillance. Little is known on BM cell recruitment and activity as BM aspirate is frequently contaminated with peripheral blood. But evidences suggest an active role of immune cells in protection against MDS and secondary leukemia. BM CD8+ CD28− CD57+ T cells are directly cytotoxic and have a distinct cytokine signature in MDS, producing TNF-α, IL-6, CCL3, CCL4, IL-1RA, TNFα, FAS-L, TRAIL, and so on. These tools promote apoptosis of aberrant cells. On the other hand, they also increase MDS-related cytopenia and myelofibrosis together with TGFβ. IL-32 produced by stromal cells amplifies NK cytotoxicity but also the vicious circle of TNFα production. Myeloid-derived suppressing cells (MDSC) are increased in MDS and have ambiguous role in protection/progression of the diseases. CD33 is expressed on hematopoietic stem cells on MDS and might be a potential target for biotherapy. MDS also has impact on immunity and can favor chronic inflammation and emergence of autoimmune disorders. BM is the site of hematopoiesis and thus contains a complex population of cells at different stages of differentiation from stem cells and early engaged precursors up to almost mature cells of each lineage including erythrocytes, megakaryocytes, myelo-monocytic cells (monocyte/macrophage and granulocytes), NK cells, and B cells. Monocytes and B cell finalize their maturation in peripheral tissues or lymph nodes after migration through the blood. On the other hand, T cells develop in thymus and are present in BM only as mature cells, just like other well vascularized tissues. BM precursors have a strong proliferative capacity, which is usually associated with a high risk for genetic errors, cell dysfunction, and consequent cell death. Abnormal cells are prone to destruction through spontaneous apoptosis or because of the immunosurveillance that needs to stay highly vigilant. High rates of proliferation or differentiation failures lead to a high rate of cell death and massive release of debris to be captured and destroyed (1). Numerous macrophages reside in BM in charge of home-keeping. They have a high capacity of phagocytosis required for clearing all these debris.

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Defects of immune surveillance offer new insights into the pathophysiology and therapy of myelodysplastic syndromes

Cited by 7 publications

References 24 publications

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Natural killer cells in leukaemia

Bone Marrow Immunity and Myelodysplasia

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