Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: The SABPA study

Malan, Leoné; Hamer, Mark; Schlaich, Markus P.; Lambert, Gavin W.; Ziemssen, Tjalf; Reimann, Manja; Frasure-Smith, Nancy; Amirkhan, James H.; Schutte, Rudolph; Rooyen, Johannes M. Van; Mels, Catharina M C; Fourie, C.M.T.; Uys, Aletta Sophia; Malan, Nico

doi:10.1016/j.atherosclerosis.2013.01.001

Cited by 37 publications

(31 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 It is thus possible that alcohol abuse in the black African male is the first line of defense to cope with taxing situations. 30 These findings support results from the present study, suggesting perturbations in various metabolic processes and systems, as a result of chronic alcohol use/abuse along with other risk factors like obesity and low-grade inflammation.…”

Section: Chronic Alcohol Abusesupporting

confidence: 94%

“…Also, a higher baseline sympathetic tone can contribute to higher energy expenditure, 29 which was evident in the male group of the main study. 30 Several variables from the metabolomics data set were important in separation of the groups. Firstly, organic acids such as lactic acid, 2-OH-isovaleric acid, 4-OH-phenyllactic acid, and fumaric acid were elevated in the hypertensive group, whereas tricarballylic acid and indole carboxylic acid glucuronide were decreased in this group.…”

Section: Metabolic Profiling Resultsmentioning

confidence: 99%

“…58 However, a demanding individualistic urban environment might also contribute to chronic stress where an ethnic group with a collectivistic orientation may not be able to exert control. 30 Behavioral adjustment to psychosocial stress was demonstrated in black African males who revealed apparent abuse of alcohol. Hamer et al demonstrated the odds of early structural vascular changes based on high GGT levels were 3.1 (95% confidence interval, 0.6-15.5) in a black African male cohort, independent of other confounders.…”

Section: Chronic Alcohol Abusementioning

confidence: 99%

See 2 more Smart Citations

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

Deventer

Lindeque

Rensburg

et al. 2015

Journal of the American Society of Hypertension

View full text Add to dashboard Cite

Section: Chronic Alcohol Abusesupporting

confidence: 94%

Section: Metabolic Profiling Resultsmentioning

confidence: 99%

Section: Chronic Alcohol Abusementioning

confidence: 99%

See 1 more Smart Citation

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

Deventer

Lindeque

Rensburg

et al. 2015

Journal of the American Society of Hypertension

View full text Add to dashboard Cite

“…The attenuated cortisol levels of the current African sub-group may therefore support the notion of increased chronic distress 19,20…”

Section: Discussionmentioning

confidence: 55%

Cortisol:brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SA BPA study

Schutte

Malan

Scheepers

et al. 2016

CVJA

View full text Add to dashboard Cite

SummaryAimEmotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore aimed to investigate associations between cardiometabolic risk markers and the cortisol-to-BDNF ratio (cortisol:BDNF).MethodsA cross-sectional study included a bi-ethnic gender cohort (n = 406) aged 44.7 ± 9.52 years. Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained.ResultsAfricans had increased incidence of hyperglycaemia and 24-hour silent ischaemic events, and elevated 24-hour blood pressure (BP) and cortisol:BDNF ratios compared to Caucasians. Forward stepwise linear regression analysis underscored a similar trend with associations between hyperglycaemia, 24-hour BP [Adj R2 0.21–0.29; β 0.23 (0.1–0.4); p = 0.01], silent ischaemia [Adj R2 0.22; β 0.40 (0.2–0.6); p < 0.01] and cortisol:BDNF levels in Africans, mostly in the men.ConclusionAttenuated cortisol levels in this group may be indicative of emotional distress and if chronic, drive the cortisol:BDNF ratio to desensitise BDNF. Desensitised cortisol:BDNF may sustain cardiometabolic risk and induce neurodegeneration in African men via silent ischaemia. Compensatory increases in blood pressure to increase perfusion and maintain homeostasis may increase coronary artery disease risk.

show abstract

“…We have recently published a detailed review on the advances in understanding the distinct physiological, lifestyle and demographic differences between black and white populations, including dietary, cultural and physiological differences [21] (e.g., suppressed renin [22], increased arterial stiffness [23–25], sympathetic nerve activity [26, 27] and an increased inflammatory profile [28, 29] in black populations). Thus, the results from the present study reflect one aspect of an entire array of factors collectively contributing to an adverse cardiovascular pro-file, specifically observed in the black women of this study, and should therefore be interpreted accordingly.…”

Section: Discussionmentioning

confidence: 99%

Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study

et al. 2018

View full text Add to dashboard Cite

Marinobufagenin (MBG) is an endogenous steroidal α1-Na+K+-ATPase inhibitor. Because of its role in sodium handling, MBG has been associated with both antihypertensive and prohypertensive effects in normal physiology and pathology. MBG is positively associated with blood pressure in Dahl salt-sensitive rats exhibiting a similar hypertensive phenotype to black populations, characterized by impaired urinary Na+ excretion. However, clinical studies exploring blood pressure (BP)-related effects of MBG in black populations are scant. We determined whether the MBG/Na+ ratio (assessing the effectiveness of Na+ excretion resistance to MBG) is related to systolic BP (SBP) in young black men and women, compared to whites. We included 331 apparently healthy participants (20–30 years) (42.9% black, 43.8% men) on a habitual diet. We obtained 24-h and central SBP, and 24-h urinary Na+ and MBG levels. We found no ethnic differences in MBG, Na+ or MBG/Na+. MBG excretion correlated positively with Na+ excretion in all groups and to SBP in white men and black women (p ≤ 0.011). In black women only SBP related positively to MBG/Na+ in single and multi-variable adjusted regression models: central SBP (R2 = 0.26; ß = 0.28; p = 0.039), 24-h SBP (R2 = 0.46; ß = 0.30; p = 0.011), daytime (R2 = 0.38; ß = 0.28; p = 0.023) and nighttime SBP (R2 = 0.38; ß = 0.33; p = 0.009). In contrast, inverse associations of MBG/Na+ with nighttime SBP were evident in white women (r = −0.20; p = 0.038) but lost significance after multiple adjustments (R2 = 0.36; ß = −0.13; p = 0.12). We found independent positive associations of SBP with MBG/Na+ in black women. This data supports the concept that reduced MBG-mediated Na+ excretion can contribute to adverse hemodynamics.

show abstract

Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: The SABPA study

Cited by 37 publications

References 23 publications

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

Cortisol:brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SA BPA study

Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study

Contact Info

Product

Resources

About