Defensive Impact of Co Q10 in Japanese Quail Males Raised Under Oxidative Stress Conditions

Abstract

This study was investigated the protective role of (CoQ10) on reproductive dysfunction of males quail induced by hydrogen peroxide (H2O2). Forty Japanese quail male 45 days old were randomly allotted into four groups with ten replicate one per each , and treated for 28 days as follows : (G1): the first control group (G2): reserved standard ratio and (1%) H2O2 in drinking water. (G3): reserved production ratio + (100 mg Co Q10/kg diet) and (1%) H2O2 in drinking water. (G4): reserved production ratio + (100 mg Co Q10/kg diet) and normal water. The results showed that exposure of birds to H2O2 caused decrease in serum glutathione level (GSH), testosterone, luteinizing hormones (LH) and follicle stimulating hormone (FSH) hormones and this reflects on histology of testis by reducing seminiferous tubules diameter , area of germinal layer and germinal layer thickness. Whereas supplement of CoQ10 caused an increase the concentrations of theses, hormones in-group G4 as compared with group G2. It can noted that an addition was able to restore the oxidative stress birds (G3) to a state close to the natural state (G1). Though testicular histological modifications were made strides in grown-up Japanese quail male treated with CoQ10. In conclusion, the comes about of the display think about appeared that utilize of Co Q10 can easing the pernicious impacts on male regenerative work takingafter introduction toH2O, maybe through enhancement the antioxidant parameters or testicular capacities or other related endocrine organs.

Coenzyme Q10 enhances testicular functions and sexual behavior through regulating steroidogenic-related gene expression and inflammatory pathways of Japanese quail (Coturnix japonica) aganist cadmium

“…CoQ10 and cadmium co-administration markedly enhanced the estimated parameters such as the reproductive organ weights, regulated testosterone concentrations, and improved sperm characteristics, which were accredited to the normalization of spermatogenesis, which led to the enhanced numbers of spermatocytes ( Taha and Al-Tikriti, 2021 ). The favorable impact of CoQ10 on adult male quail fertility might be caused by its antioxidant properties ( Tsao et al., 2021 ).…”

“…In addition, CoQ10 is considered to be a powerful antioxidative agent; predominantly, the reactive oxygen species gathering, and subsequently testicular oxidative injury in Leydig cells by a particular chemical oxidant, might fail their response and performance to produce testosterone. CoQ10 is an antioxidant inside the cell that safeguards mitochondrial layer protein, layer LDL-C and phospholipids, and free radical-triggered oxidative damage ( Taha and Tikriti, 2021 ). Moreover, CoQ10 is an antioxidant when supplied to mature males by falling MDA levels in seminal plasma and blood, testis histology clearances, and development make strides in sex hormone ( Mollaei et al., 2022 , Sarica et al., 2007 ).…”

“…Group 1 was administered with a basal ration following the NRC ( 1994 ) guidelines ( Table 1 ). The quails of Group 2 were delivered with a basal ration dispensed with CoQ10 at a 100 mg/kg diet ( Taha and Al-Tikriti, 2021 ). Group 3 was fed a basal ration administered with cadmium at a 50 mg/kg diet ( Butt et al., 2018 ).…”