Deferiprone solubility in some non-aqueous mono-solvents at different temperatures: experimental data and thermodynamic modelling

Thermodynamic Modeling and Solubility Measurement of Cetirizine Hydrochloride and Deferiprone in Pure Solvents of Acetonitrile, Ethanol, Acetic Acid, Sulfolane, and Ethyl Acetate and Their Mixtures

“…Similarly, Table demonstrates the experimental solubility of deferiprone in acetonitrile, ethanol, and ethyl acetate within the temperature range of 283.15–323.15 K using UV spectroscopy. Moreover, one can see the experimental solubility of deferiprone in the same monosolvents by Fathi-Azarbayjani et al and Jouyban et al using the flask-shake method through UV spectroscopic measurements. Besides, the experimental solubility of deferiprone in ethyl acetate and acetonitrile was measured by Yousefi Seyf and Haghtalab, and their results are compared to those of the present study as shown in Table .…”

“…As is seen, in spite of the almost same measurement procedures, there are some differences and close agreement among the present measurements and the literature data. The solubility data given by Fathi-Azarbayjani et al and Jouyban et al are expressed in terms of mol/L; however, by using the correlated density data of the present monosolvents, we converted the literature data into mole fraction. On the other hand, the supplied deferiprone and the solvents, which we used in this work, were purchased from the various companies so that the suppliers of the materials were used by the mentioned researchers are different.…”

“…In addition, the solubility of deferiprone in each solvent was also enhanced by temperature so that the solubility order was ethanol > acetonitrile > ethyl acetate. Jouyban et al . reported the solubility of deferiprone in different monosolvents and concluded that the solubility (mol/L) obeyed the following order from high to low in different monosolvents: dichloromethane > chloroform > acetonitrile > 1,4-dioxane > ethyl acetate.…”

“…The chemical formula of these drug compounds is shown in Figure . Jouyban et al measured the solubility of deferiprone in some nonaqueous monosolvents such as dichloromethane, chloroform, acetonitrile, 1,4-dioxane, and ethyl acetate at different temperatures ranging from 293.15 to 313.15 K using the flask-shake method under atmospheric pressure . Moreover, Fathi-Azarbayjani et al obtained experimentally the data of the deferiprone solubility in water, ethanol (EtOH), and N -methyl-2-pyrrolidone (NMP) at 293.2, 298.2, 303.2, 308.2 and 313.2 K under atmospheric pressure using the flask-shake method .…”

Solubility Data and Computational Modeling of Baricitinib in Various (DMSO + Water) Mixtures

“…Co-solvency and formulation techniques for solubilization of BNB are poorly reported in the literature. Solubility and thermodynamics data of poorly soluble drugs in neat solvents and water-co-solvent mixtures have greater impact in various fields which includes "medical sciences (preclinical and clinical studies), pharmaceutical sciences (pre-formulation studies and dosage form design), chemical sciences (purification and recrystallization) and physical pharmacy (physicochemical characterization)" [5][6][7][8]. The solubility and solution thermodynamic properties of BNB in some mono-solvents such as water, ethanol, polyethylene glycol-400, ethyl acetate, dichloromethane and dimethyl sulfoxide (DMSO) at "T = 298.2-323.2 K" and "p = 0.1 MPa" have been reported in literature [8].…”