Deferoxamine in the management of COVID-19 adult patients admitted to ICU: a prospective observational cohort study

Abstract

Background: COVID-19 infection is associated with high mortality, and despite extensive studying the scientific society is still working to find a definitive treatment. Some experts postulated a beneficial role of Deferoxamine. Aim: The aim of this study was to compare the outcomes of COVID-19 adult patients admitted to the ICU who received deferoxamine to those who received standard of care. Methods: Prospective observational cohort study, in the ICU of a tertiary referral hospital in Saudi Arabia to compare all-cause hospital mortality between COVID-19 patients who received deferoxamine and standard of care. Results: A total of 205 patients were enrolled, with an average age of 50.1±14.3, 150 patients received standard of care only, and 55 patients received deferoxamine additionally. Hospital mortality was lower in deferoxamine group (25.5 vs. 40.7%, 95% CI=1.3–29.2%; P=0.045). Clinical status score upon discharge was lower in deferoxamine group (3.6±4.3 vs. 6.2±4, 95% CI: 1.4–3.9; P<0.001), as was the difference between discharge score and admission score (indicating clinical improvement). More patients admitted with mechanical ventilation were successfully extubated in the deferoxamine group (61.5 vs. 14.3%, 95% CI: 15–73%; P=0.001), with a higher median ventilator-free days. There were no differences between groups in adverse events. Deferoxamine group was associated with hospital mortality [odds ratio=0.46 (95% CI: 0.22–0.95); P=0.04]. Conclusions: Deferoxamine may have mortality and clinical improvement benefits in COVID-19 adults admitted to ICU. Further powered and controlled studies are required.

COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect?

“…Studies have demonstrated that both iron chelators and lipophilic antioxidants could prevent the progression of PD [ 107 ]. Furthermore, deferoxamine lowers the amounts of IL-6, a major inflammatory cytokine generated during COVID-19 [ 108 ], suggesting that deferoxamine may be used as a medication to treat COVID-19-induced PD. Nevertheless, no study has yet evaluated the effectiveness of lipophilic antioxidants in the COVID-19 therapy process.…”