Deficiência de zinco em crianças e adolescentes com doenças hepáticas crônicas

Pereira, Thalita Cremonesi; Hessel, Gabriel

doi:10.1590/s0103-05822009000300014

Cited by 15 publications

(6 citation statements)

References 45 publications

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“…However, several factors like infection, inflammation, hemolysis, stress, and homeostasis may change the plasma zinc level which may lead to false determinations. Moreover, the amount of zinc in erythrocytes showed instability in a population study, hence, lead to misinterpretation of the results due to these factors (Pereira et al 2009).…”

Section: The Physiological and Metabolic Role Of Zincmentioning

confidence: 99%

Kalsiyum İyonu ve Pompalarının Kas Kasılma/ Gevşemesindeki Kritik İşlevleri

İnal¹,

Gümüş²,

Koca³

et al. 2023

Sağlık Bilimleri Araştırmaları: Temel Tıp

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Organizma, uyarılabilir dokular olan kasların kasılıp gevşemesi ile yaşamını sürdürebilir. Kalsiyum (Ca2+) iyonu kaslarda hem kasılma hem de gevşemede kilit rol oynar. Kas hücrelerinin kasılıp gevşemesi Ca2+ iyonunun hücre içi konsantrasyonunun düzenlenmesi ile sağlanabilir. Ca2+ iyon konsantrasyonu düzenlenmesi elektrokimyasal gradiyent ve membran iyon pompaları vasıtasıyla gerçekleştirilir. Diyastolik ve sistolik fonksiyon bozuklukları kalp kası kasılma ve gevşeme sorunlarını temsil eden yaygın bir durumdur. Bu nedenle, başta kalp kası ve tüm kaslarda kasılma ve gevşeme mekanizmaları ile bu mekanizmalarda Ca2+ iyonu rollerinin tüm açıklığıyla bilinmesi önemlidir. Bu bölümde, vücut homeostazisinin sağlanmasında önemli role sahip olan Ca2+ iyon ve pompalarının kas kasılma ve gevşemesi üzerindeki kilit rolleri ve Ca2+ iyon konsantrasyonlarının düzenlenmesi tartışılacaktır.

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Section: The Physiological and Metabolic Role Of Zincmentioning

confidence: 99%

Kalsiyum İyonu ve Pompalarının Kas Kasılma/ Gevşemesindeki Kritik İşlevleri

İnal¹,

Gümüş²,

Koca³

et al. 2023

Sağlık Bilimleri Araştırmaları: Temel Tıp

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“…We know that zinc absorption can occur by diffusion or by transporters, with the jejunum being the site of greatest uptake of this mineral. We have factors that can impair this process, such as the presence of phytates, oxalates, tannins and polyphenols, as well as facilitators, among them the presence of cysteine and histidine, phosphates, organic acids and protein (PEREIRA, 2009). Zinc plays an important role in the endocrine system, as well as in other systems of the organism: it participates, for example, as a cofactor of the enzyme deiodinidase type II, in the peripheral conversion of thyroxine (T4) into triiodothyronine (T3), being this reaction diminished, contributes to the manifestation of disorders, such as subclinical hypothyroidism (MARQUES, 2006).…”

Section: A Look At Developmentmentioning

confidence: 99%

The nutritional status of zinc in children and adolescents with down syndrome: Child development under discussion

Delambert,

Santos,

Moreira

et al. 2023

A Look at Development

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Down Syndrome (DS) is a chromosomal disorder. Studies have sought the mechanisms involved in the pathophysiology of diseases associated with DS, as well as the factors that contribute to changes growth and development. Thyroid dysfunctions as well as micronutrient deficiencies have already been evidenced. Zinc is one of the micronutrients involved in the processes of cell differentiation, height growth, neurological development and immune defense, and its deficiency can lead to damage in children with DS. There are no studies in Brazil and the real magnitude of this deficiency is not known in the general population and more specifically among those with DS. The objective of this study was to evaluate the nutritional status of zinc in children and adolescents with and to verify the response to supplementation of this micronutrient, proposing an assistance protocol for this population. A case-control clinical study and a randomized clinical trial, accomplished in 2020 and 2021, in an outpatient service of a University Hospital, with a convenience sample. Case Group: children and adolescents with DS, paired by sex and age with the control group, without the syndrome (1:1), wirh the laboratory analysis of erythrocyte and serum zinc dosages, in addition to assessment of dietary zinc intake. Study approved by the Research Ethics Committee. The results shows differences between groups were significant in relation to birth weight (p=0.04), and regarding the level of erythrocyte zinc (p<0.001), lower in the control group, despite the fact that the diet of both groups did not show insufficiency in the consumption of this micronutrient. We considerer that with the improvement of care for these children and adolescents will promote better growth and development, impacting their quality of life and that of their caregivers. In opposition to what is described in the literature, children and adolescents with Down syndrome presented better adequacy of the nutritional status of zinc than the control group. The results highlight the relevance of regular follow-up in a health care service, with integral care and multidisciplinary team, from the first months of life.

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“…Sabe-se que alguns fatores podem interferir no metabolismo do zinco, reduzindo o poder de discriminação diagnóstica de indicadores do estado nutricional desse mineral. Vários fatores fisiológicos, como a baixa albumina sérica, contagens elevadas de células brancas no sangue, hemólise, presença de processos inflamatórios e estresse, podem afetar os níveis séricos de zinco 15,26 . Por sua vez, os níveis de zinco no cabelo podem variar de acordo com o estado de desnutrição, características do cabelo (cor, tamanho, contaminação externa por ar, água, suor, xampus, sabonetes, tratamento capilar etc.)…”

Section: I S C U S S ã Ounclassified

Avaliação de desempenho das concentrações capilares de zinco como método diagnóstico da deficiência de zinco: um estudo comparativo com as concentrações séricas de zinco

Pedraza

Sales

2013

Rev. Nutr.

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OBJETIVO: Examinar o poder diagnóstico de deficiência de zinco das concentrações capilares desse mineral por meio da comparação com as concentrações séricas. MÉTODOS: Estudo transversal desenvolvido com 170 crianças na faixa etária dos 12 aos 72 meses. A análise da Curva Característica de Operação do Receptor foi utilizada para identificar a sensibilidade e a especificidade do melhor ponto de corte para o diagnóstico da deficiência de zinco no cabelo. Verificou-se ainda a significância estatística da área sob a curva. RESULTADOS:O ponto de corte apontado como ótimo para o zinco no cabelo foi de 292,52ppm (sensibilidade de 55,6% e especificidade de 60,8%), com uma área sob a curva de 0,549, sem significância estatística. CONCLUSÃO: O diagnóstico da deficiência de zinco pelas concentrações capilares desse elemento, em comparação às concentrações séricas de zinco, mostra baixa sensibilidade e ponto de corte ideal superior ao sugerido. Permanece, ainda, a necessidade de novos estudos que possibilitem a obtenção de indicadores bioquímicos mais sensíveis e específicos para o diagnóstico da deficiência de zinco na população, sob tudo sem importantes limitações técnicas.

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Deficiência de zinco em crianças e adolescentes com doenças hepáticas crônicas

Cited by 15 publications

References 45 publications

Kalsiyum İyonu ve Pompalarının Kas Kasılma/ Gevşemesindeki Kritik İşlevleri

Kalsiyum İyonu ve Pompalarının Kas Kasılma/ Gevşemesindeki Kritik İşlevleri

The nutritional status of zinc in children and adolescents with down syndrome: Child development under discussion

Avaliação de desempenho das concentrações capilares de zinco como método diagnóstico da deficiência de zinco: um estudo comparativo com as concentrações séricas de zinco

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