Deficiencies of Magnesium Replacement in the Critically Ill

Ryman, Klayton; Canada, Todd W.

doi:10.1177/0885066617735784

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A common rule of thumb for IV magnesium replacement is a serum change range of 0.08 to 0.18 mg/dL per gram administered; therefore, the change expected from 3 to 5 g of IV magnesium would have been 0.2 to 0.9 mg/ dL. 2,3 Unfortunately, various other factors were not reported including renal function, use of enteral or oral nutrition, presence of diarrhea, and insulin or diuretic use that could have affected the primary and secondary outcomes. In addition, the number of patients who received oral magnesium was reported, but the rationale why it was used (over IV replacement or concurrently), dose, and number of days received were not, as this could have contributed to fecal magnesium losses.…”

Section: To the Editormentioning

confidence: 99%

Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Zhou

Canada

2019

Hosp Pharm

Self Cite

View full text Add to dashboard Cite

Section: To the Editormentioning

confidence: 99%

Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Zhou

Canada

2019

Hosp Pharm

Self Cite

View full text Add to dashboard Cite

“…3,4 More specifically, low magnesium levels were associated with poor endothelial reactivity, higher oxidative stress, increased intima-media thickness, vascular calcification, progression of CKD and mortality. [5][6][7] Hypomagnesaemia is a common entity occurring up to 12% of hospitalized patients and up to 60% of patients in intensive care settings though often missed. Symptomatic magnesium depletion may be due to gastrointestinal or renal losses.…”

Section: Introductionmentioning

confidence: 99%

Hypomagnesaemia among children at pediatric intensive care unit, Nishtar Hospital, Multan.

Joiya

Khan

Shabbir

2020

TPMJ

View full text Add to dashboard Cite

Objectives: Magnesium is the 2nd most abundant intracellular cation and it is vital for more than 300 enzymatic reactions which are involved in various metabolic processes in our body, but still, it is often a parameter which is overlooked by the clinicians. This study was conducted to determine the frequency of hypomagnesaemia among children admitted in pediatric intensive care unit (PICU). Study Design: Cross-sectional study. Setting: Department of Pediatric medicine, Unit-I, Nishtar Hospital, Multan. Periods: From 1st August 2017 to 31st May 2018. Material & Methods: A total of 379 children of age group 1-12 years and either gender were admitted at PICU irrespective of presenting complaint with duration of illness less than 2 weeks were included. Post stratification chi-square test was applied to see the effect of different variables like age of the patients, BMI, duration of illness and serum Magnesium levels, hypomagnesaemia, residential status, socioeconomic status, mother’s education and gender, on hypomagnesaemia. P value < 0.05 was considered as significant. Results: Of these 379 study cases, 221(58.3%) were boys while 158 (41.7%) were girls. Mean age of our study cases was 4.81 ± 2.27 years. Mean duration of illness was 5.57 ± 2.34 days. Mean weight of study cases was 17. 30 ± 5.92 kilograms. Mean serum Magnesium level was 1.45 ± 0.67 mg/dl. Hypomagnesemia was found to be present in 190 (50.1%). Male gender, urban residential status, illiteracy, hospitalization before PICU admission, disease duration of 1 to 2 weeks and weight < 20 kg turned out to be significantly associated (p < 0.05) with hypomagnesaemia. Conclusion: High frequency of hypomagnesaemia was noted among children admitted at PICU. Children with hypomagnesaemia had prolonged hospital stay and adverse outcomes. Hypomagnesaemia was significantly associated with male gender, residential status, mother’s educational level, hospitalization before PICU admission, disease duration and weight.

show abstract

Hypomagnesemia in critically ill patients

2018

View full text Add to dashboard Cite

BackgroundMagnesium (Mg) is essential for life and plays a crucial role in several biochemical and physiological processes in the human body. Hypomagnesemia is common in all hospitalized patients, especially in critically ill patients with coexisting electrolyte abnormalities. Hypomagnesemia may cause severe and potential fatal complications if not timely diagnosed and properly treated, and associate with increased mortality.Main bodyMg deficiency in critically ill patients is mainly caused by gastrointestinal and/or renal disorders and may lead to secondary hypokalemia and hypocalcemia, and severe neuromuscular and cardiovascular clinical manifestations. Because of the physical distribution of Mg, there are no readily or easy methods to assess Mg status. However, serum Mg and the Mg tolerance test are most widely used. There are limited studies to guide intermittent therapy of Mg deficiency in critically ill patients, but some empirical guidelines exist. Further clinical trials and critical evaluation of empiric Mg replacement strategies is needed.ConclusionPatients at risk of Mg deficiency, with typical biochemical findings or clinical symptoms of hypomagnesemia, should be considered for treatment even with serum Mg within the normal range.

show abstract

Deficiencies of Magnesium Replacement in the Critically Ill

Cited by 3 publications

References 7 publications

Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Hypomagnesaemia among children at pediatric intensive care unit, Nishtar Hospital, Multan.

Hypomagnesemia in critically ill patients

Contact Info

Product

Resources

About