Deficiency in the Thymus-Dependent Immunity in “Lethargic” Mutant Mice1

Hc, Dung

doi:10.1097/00007890-197701000-00007

Cited by 23 publications

(10 citation statements)

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“…In deed, in many ways these mice respond like an outbred line. It would be interesting to determine if the tumor susceptibility spectrum and other cell-mediated im munological phenomena [6] can be correlated in any way with H-2 histocompatability loci which has yet to be determined in this unique strain of mice.…”

Section: Discussionmentioning

confidence: 99%

“…Studies are now in progress to determine the dif ferences in the tumor susceptibility spectrum of homo zygous recessive 'lethargic' (lh /lh ) mutant BALB/ cGnDu mice, which phenotypically express a defect in their cell-mediated immune response [6], Studies com paring these lethargic mutants to phenotypically nor mal animals offer a unique opportunity to study the genetics and pathophysiology of a defect in the thymicdependent immune response. Additionally, these ani mals may prove a useful model for studies on hormonal relationships to thymic development and tumorigenesis (e.g., for Cushing's syndrome and similar diseases where adrenal malfunction and adrenal steriods are associated with tumor growth [1]).…”

Section: Discussionmentioning

confidence: 99%

“…Individual mice expres sing this mutation, 'lethargic' (lh /lh ), show a spon taneous thymic involution 3-4 weeks after birth [4,7). The lethargic mutants have a deficiency in their cellmediated immune response at 3^4 weeks of age which may be spontaneously corrected in adult survivors [6]. Dung [5] has provided evidence that the thymic invo lution of mutant individuals may be related to hyper activity of the adrenal gland.…”

Section: Introductionmentioning

confidence: 99%

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Susceptibility of BALB/cGnDu Mice to Transplantable Tumors, in vitro Transformed Cells, BK and SV40 Viruses, and Chemical Carcinogens

Morrison¹,

Moyer

Lynd

et al. 1982

Oncology

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Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviruses and 3 chemical carcinogens evaluated, only the Harding-Passey amelanotic melanoma produced tumors in 100% of the normal adult mice injected. The S180 pleomorphic sarcoma produced tumors in 56% of normal adult mice. Although not tumorigenic in adults, the mKSA, Morris (rat) hepatoma No. 7777, and a human papovavirus – transformed human cell induced mouse tumor line [GIllO(BK) B6D2 Tu] formed tumors in 100, 62 and 70%, respectively, of recipients inoculated as neonates. SV40 and human papovavirus BK virions, as well as SV40, BK, and spontaneous in vitro transformed BALB/cGnDu cells were not tumorigenic. Although the histocompatibility antigens of these animals have not been studied, no correlations could be made between the tumor susceptibility of these animals with regard to the commonly employed inbred line BALB/c nor with regard to the range of host susceptibility of the transplantable tumors. This inbred subline represents a new strain of mice whose genetic defect makes it useful for transplantation immunology and physiological genetics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Susceptibility of BALB/cGnDu Mice to Transplantable Tumors, in vitro Transformed Cells, BK and SV40 Viruses, and Chemical Carcinogens

Morrison¹,

Moyer

Lynd

et al. 1982

Oncology

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“…However, electrophysiologic studies of homo zygotes have shown peripheral neuropathies (266). Defects in the immune system diminish with age, and those mutant mice that survive to 45 days have normal immune function (267). Defects in the immune system diminish with age, and those mutant mice that survive to 45 days have normal immune function (267).…”

Section: Lethargicmentioning

confidence: 99%

Genetically Determined Murine Models of Immunodeficiency

Shultz¹,

Sidman²

1987

Annu. Rev. Immunol.

166

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We have discussed more than 30 mutant genes known to cause abnormalities in the development and regulation of the immune system. The loci defined by these deleterious alleles have been assigned to 13 different autosomal chromosomes in addition to X and Y. It is important to note that these single genes do not act alone but function in concert with the background genome. Studies of these mutations on different inbred strain backgrounds are contributing important information on the influence of background modifying genes. The development of stocks of mice carrying multiple mutations on an inbred strain background enables the use of a well-characterized mutation to explore a less-well-understood genetic model. Investigators are urged to assure proper conditions for studies with immunological mutants by using the appropriate methods of animal husbandry. A detailed guide for maintaining immunologically compromised rodents has been prepared. These experiments performed by nature provide a valuable resource for investigating the immune system in normal and pathologic states. As the gene products of the loci defined by these mutations become known, the information obtained will provide additional insight into mechanisms underlying normal immune function as well as immunologic disease processes in man.

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“…Lethargic mice, a mutant strain, suffer from a neurologic abnormality that develops before weaning, lasts 30-60 d, and then gradually disappears. This neurological disease is associated with thymic atrophy; the thymus returns to normal as soon as the neural disturbance disappears [62]. Both thymectomized and nude mice, another mutant strain that shows thymic atrophy, display a profoundly disturbed neuroendocrine balance [63].…”

Section: Introductionmentioning

confidence: 99%

Psychoneuroimmunology: Interactions between central nervous system and immune system

Solomon

1987

J of Neuroscience Research

204

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Psychoneuroimmunology, a rapidly developing field, has to do with the complex bidirectional interactions between the central nervous system and the immune system. Neuroendocrine influences modulate immune function, and there is feedback from the immune system to the brain. CNS-immune interaction appears to play a role in psychosocial influences on immunologically resisted and mediated diseases. With the growing evidence now at hand, over 30 "postulates" can be proposed for specific implications of CNS-immune interaction.

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Deficiency in the Thymus-Dependent Immunity in “Lethargic” Mutant Mice1

Cited by 23 publications

References 0 publications

Susceptibility of BALB/cGnDu Mice to Transplantable Tumors, in vitro Transformed Cells, BK and SV40 Viruses, and Chemical Carcinogens

Susceptibility of BALB/cGnDu Mice to Transplantable Tumors, in vitro Transformed Cells, BK and SV40 Viruses, and Chemical Carcinogens

Genetically Determined Murine Models of Immunodeficiency

Psychoneuroimmunology: Interactions between central nervous system and immune system

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