1952
DOI: 10.1126/science.116.3018.484
|View full text |Cite
|
Sign up to set email alerts
|

Deficiency of Ceruloplasmin in Patients with Hepatolenticular Degeneration (Wilson's Disease)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
123
1
8

Year Published

1954
1954
2013
2013

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 399 publications
(134 citation statements)
references
References 8 publications
2
123
1
8
Order By: Relevance
“…To date, hypocupremia has been observed consistently in human subjects in only three situations; namely, the newborn (28), Wilson's disease (5,29,30), and the nephrotic syndrome. A dietary deficiency of copper has not, as yet, been clearly demonstrated in a human subject (31).…”
Section: Discussionmentioning
confidence: 99%
“…To date, hypocupremia has been observed consistently in human subjects in only three situations; namely, the newborn (28), Wilson's disease (5,29,30), and the nephrotic syndrome. A dietary deficiency of copper has not, as yet, been clearly demonstrated in a human subject (31).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, normally, changes in the concentration of serum copper parallel those of ceruloplasmin. A decreased concentration of serum copper is most frequently the consequence of inadequate synthesis of ceruloplasmin, as in Wilson's disease (4) ; of interference with protein synthesis associated with severe malnutrition (5) or rarely severe hepatic dysfunction (6) ; or of excessive urinary or fecal losses from the body (7,8). The present study presents evidence that impaired absorption of copper may also result in a decreased concentration of serum ceruloplasmin.…”
mentioning
confidence: 60%
“…It was twelve years later, in 1948, that Cumings 18 described the copper abnormalities in Wd and posteriorly, in 1952, Scheinberg and Gitlin 19 showed that the ceruloplasmin levels were low in most of Wd patients.…”
Section: Discussionmentioning
confidence: 99%