Deficiency of essential fatty acids during pregnancy and avoidance learning in the progeny

Galli, Cláudio; Messeri, Patrizia; Oliverio, Alberto; Paoletti, Rodolfo

doi:10.1016/s0031-6989(75)80031-2

Cited by 34 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has also been shown that a n-3 PUFA-deficient diet in rats increased the rate of neonatal mortality Francois et al, 1980), impaired learning ability (Galli et al, 1975 ;Lamptey and Walker, 1978 ;Francois, 1983), caused disorders in vision physiology (Wheeler et al, 1975 ;Francois, 1983 ;Nouvelot et al, 1985) and modified some membrane enzyme activities which could alter membrane physiology (Bernsohn and Spitz, 1974 ;Sun and Sun, 1974 ;McMurchie and Raison, 1979 (Neuringer et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Dietary α-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth

Guesnet¹,

Pascal²,

Durand³

1986

Reprod. Nutr. Dévelop.

View full text Add to dashboard Cite

Summary. The effects of a dietary a-linolenic acid (18 : 3 n-3) deficiency on reproduction and postnatal growth in rats were studied during 3 successive gestations and 4 successive generations. Female rats received respectively a semi-synthetic diet in which the lipids were incorporated either as sunflower oil at 1.5 % (deficient diet) or as soya oil at 1.87 % (control diet).Both diets supplied the same amount of linoleic acid (18 : 2 n-6) (940 mg/100 g of diet), but the sunflower oil supplied 22 times less a-linolenic acid than the soya diet (6 mg vs 130 mg/100 g of diet).The results showed that, in our experimental conditions, the a-linolenic acid deficiency had no effect on fecundity (% of pregnant females), fertility (number of pups/litter), pup birth weight, food intake and weight of pregnant or lactating females, or pup growth during suckling.However, this deficiency did cause abnormally high rates of perinatal mortality from birth to postpartum day 3, namely on the average, for successive gestations : 18.5 % in deficient pups vs 5.2 % in the controls, and for successive generations : 16.6 % in deficient pups vs 5.3 % in the controls.Rat n-3 PUFA requirement during reproduction has been discussed ; it appears to be more than 100 mg/100 g of feed. But this need should also be estimated in relation to n-6 PUFA supply ; for female rats during reproduction, the ratio n-6 : n-3 should be less than 10.

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary α-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth

Guesnet¹,

Pascal²,

Durand³

1986

Reprod. Nutr. Dévelop.

View full text Add to dashboard Cite

show abstract

“…Moreover, n-3 PUFA are powerful hypocholesterolemic and hypotriglyceridemic agents (Nordoy, 1965 ;Peifer, 1966 ;Dyerberg et al, 1975 ;Harris et al, 1983 ;Fehily et al, 1983 ;Durand et al, 1985). When the diet is deficient in these n-3 PUFA, n-3 fatty acids are usually replaced by n-6 fatty acids or, more strictly speaking, most of the 22 : 6 n-3 is replaced by 22 : 5 n-6 (Galli et al, 1971(Galli et al, , 1974Cohen and Bernsohn, 1978 ;Tinoco et al, 1978 ;Menon and Dhopeshwarkar, 1981 ;Nouvelot et al, 1983a,b ;Bourre er al., 1984 ;Youyou et al, 19861. However, when this occurs, the physiological status is not normal, resulting in an attention of the electroretinogram (ERG) (Wheeler et al, 1975 ;Neuringer et al, 1984Neuringer et al, , 1986aNouvelot et al, 1985), higher neonatal mortality (Sinclair and.Crawford, 1973 ;Francois et al, 1980 ;Guesnet et al, 1986), decreased learning ability (Galli et al, 1975 ;Lamptey and Walker, 1978), changes in enzyme activities which may alter membrane physiology (Bernsohn and Spitz, 1974 ;Sun and Sun, 1974 ;McMurchie and Raison, 1979 ;Flier et al, 1985), and neurological disorders (Holman et al, 1982). Now, membrane structures, and particularly those of the nervous.system, develop intensely during the foetal period and lactation (Sinclair and Crawford, 1972 ;Crawford et al, 1981 ;Bourre, 1984 ;Menon and Dhopeshwarkar, 1982).…”

mentioning

confidence: 99%

Effects of dietary α-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat

Guesnet¹,

Pascal²,

Durand³

1988

Reprod. Nutr. Dévelop.

View full text Add to dashboard Cite

show abstract

“…DeWille and Farmer [30] showed that postnatal EFA deficiency influences myelin synthesis, reducing the mRNAs involved in myelination. Pre-and postnatal EFA deficiency was found to impair learning in rodents [31,32] and to cause motor and vision abnormalities in humans [33].…”

Section: Dietary Fatty Acids and Myelinmentioning

confidence: 99%

Diet, Lipids and Brain Development

Salvati¹,

Attorri²,

Avellino³

et al. 2000

Dev Neurosci

View full text Add to dashboard Cite

Brain development is a sequential anatomical process characterised by specific well-defined stages of growth and maturation. One of the fundamental and necessary events in the normal development of the central nervous system in vertebrates is the formation of a myelin sheath. It is becoming more evident that this process is influenced by dietary lipids. A number of findings have indicated that the administration of a diet deficient in essential fatty acids during development causes hypomyelination in the rat brain. Our studies have shown that lipids can also play a role in accelerating myelinogenesis in the brain of rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n-alkanes. Further studies have shown that accelerated myelinogenesis is connected to a precocious appearance of behavioural reflexes. Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development.

show abstract

Deficiency of essential fatty acids during pregnancy and avoidance learning in the progeny

Cited by 34 publications

References 10 publications

Dietary α-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth

Dietary α-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth

Effects of dietary α-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat

Diet, Lipids and Brain Development

Contact Info

Product

Resources

About