Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis

Jusek, Gabriela; Reim, Daniel; Tsujikawa, Kazutake; Holzmann, Bernhard

doi:10.1016/j.imbio.2012.04.009

Cited by 29 publications

(20 citation statements)

References 59 publications

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“…Recently, macrophages have been studied in the context of pain induction and their involvement in pain pathways during inflammation (Hasegawa-Moriyama et al, 2013; Isami et al, 2013; Taves et al, 2013). In various studies, CGRP treatment increased IL10 from both peritoneal and bone marrow derived macrophages in response to LPS (Jusek et al, 2012). CGRP receptor absence resulted in the influx of neutrophils and inflammatory mediators into the peritoneal cavity (Jusek et al, 2012).…”

Section: Regulation Of Other Immune Cellsmentioning

confidence: 97%

“…The interaction of T cell with DCs and macrophages, both of which express the CGRP receptor, is influenced by CGRP expression. (Ben-Horin and Chowers, 2008; Rochlitzer et al, 2011; Jusek et al, 2012; Holzmann, 2013). The capability of CGRP to regulate T cell function was proposed as early as 1988 (Umeda et al, 1988).…”

Section: Cgrp Regulates Lymphocyte Differentiation and Cytokine Produmentioning

confidence: 99%

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Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

2014

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The question of how the neural and immune systems interact in host defense is important, integrating a system that senses the whole body with one that protects. Understanding the mechanisms and routes of control could produce novel and powerful ways of promoting and enhancing normal functions as well as preventing or treating abnormal functions. Fragmentation of biological research into specialities has resulted in some failures in recognizing and understanding interactions across different systems and this is most striking across immunology, hematology, and neuroscience. This reductionist approach does not allow understanding of the in vivo orchestrated response generated through integration of all systems. However, many factors make the understanding of multisystem cross-talk in response to a threat difficult, for instance the nervous and immune systems share communication molecules and receptors for a wide range of physiological signals. But, it is clear that physical, hard-wired connections exist between the two systems, with the key link involving sensory, unmyelinated nerve fibers (c fibers) containing the neuropeptide calcitonin gene-related peptide (CGRP), and modified macrophages, mast cells and other immune and host defense cells in various locations throughout the body. In this review we will therefore focus on the induction of CGRP and its key role in the neuroimmune axis.

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Section: Regulation Of Other Immune Cellsmentioning

confidence: 97%

Section: Cgrp Regulates Lymphocyte Differentiation and Cytokine Produmentioning

confidence: 99%

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

2014

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“…In LPS-induced shock, nociceptor-derived neuropeptides CGRP, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) decrease cytokine levels and mortality in mice with exogenous administration [79,80]. In a model of polymicrobial septic peritonitis, deficiency in RAMP1 led to increased innate immune cell recruitment and decreased IL-10 levels [77]. Thus, nociceptor neurons-derived neuropeptides limit the innate inflammatory response.…”

Section: Nociceptor Neuron Regulation Of Inflammation and Immunitymentioning

confidence: 99%

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

Pinho‐Ribeiro

Verri

Chiu

2017

Trends in Immunology

747

626

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Nociceptor sensory neurons protect organisms from dangers by eliciting pain and driving avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly clear that active crosstalk occurs between nociceptor neurons and the immune system to regulate pain, host defense, and inflammatory diseases. Immune cells at peripheral nerve terminals and within the spinal cord release mediators that modulate mechanical and thermal sensitivity. In turn, nociceptor neurons release neuropeptides and neurotransmitters from nerve terminals that regulate vascular, innate, and adaptive immune cell responses. Therefore, the dialogue between nociceptor neurons and the immune system is a fundamental aspect of inflammation, both acute and chronic. A better understanding of these interactions could produce approaches to treat chronic pain and inflammatory diseases.

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“…For example, RAMP deletion studies or transgenic models have given valuable insight into the functional roles of the receptors for the calcitonin family of peptides, including the two AM receptor subtypes and the CGRP receptor (30–33). The AM 1 and AM 2 receptors are derived from the interaction of CLR with RAMP2 or RAMP3, respectively.…”

Section: New Insights From Animal Modelsmentioning

confidence: 99%

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

Hay

Pioszak

2016

Annu. Rev. Pharmacol. Toxicol.

155

151

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Once considered as largely independent functional units, G protein-coupled receptors (GPCRs) are now recognized as having a far more diverse molecular architecture. Receptor activity-modifying proteins (RAMPs) provide a major example of proteins that interact with GPCRs to modify their function. RAMPs are able to act as pharmacological switches, chaperones, regulate signaling and/or trafficking in a receptor-dependent manner. This review covers recent discoveries in the RAMP field and summarizes the known GPCR partners and functions of RAMPs. We also discuss the first peptide-bound structures of RAMP-GPCR complexes, which give insight into the molecular mechanisms as to how RAMPs can alter the pharmacology of GPCRs and their signaling.

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Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis

Cited by 29 publications

References 59 publications

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

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