Deficiency of vitamin B12 and its relation with neurological disorders: a critical review

Nawaz, Aisha; Khattak, Noor Nasir; Khan, M. S.; Nangyal, Hasnain; Sabri, Sabeen; Shakir, Muhammad

doi:10.1186/s41936-020-00148-0

Cited by 39 publications

(32 citation statements)

References 50 publications

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“…Even though coexisting comparable disease severity has been seen, mostly either hematological or neurological complaints prevail. The nervous system can be involved at multiple levels, causing subacute degenerative disorder, peripheral neuropathies, and neuropsychiatric symptoms [ 28 ]. Among the cranial nerves, olfactory and optic nerves are most commonly involved [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report

Ata

Bilal

Javed

et al. 2020

Annals of Medicine and Surgery

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Introduction Vitamin B12 (VitB12) deficiency rarely manifests with visual symptoms. Optic nerve damage in VitB12 deficiency is thought to be via degeneration. However, optic neuritis, though infrequent, has been reported secondary to VitB12 deficiency. Material and methods We conducted a systematic review of all the reported cases of VitB12 deficiency with optic nerve involvement in Pubmed, Cochrane, and Google Scholar any date up to September 6, 2020. We have discussed the findings and compiled the available information on ophthalmological manifestations of VitB12 deficiency. We aim to provide a unified knowledge about the evidence related to types of optic neuropathies reported to date secondary to VitB12 deficiency. We also present a case of bilateral optic neuritis secondary to VitB12 deficiency. Presentation of case We present a 29-year-old previously healthy male with progressive, painful, bilateral, but asymmetric visual deterioration for forty-five days. A detailed history, examination, and laboratory workup were carried out. He was diagnosed as having optic neuritis secondary to VitB12 deficiency. He showed partial improvement with the replacement of VitB12. Conclusion We suggest promptly identifying and replacing VitB12 in patients with optic neuritis with proven VitB12 deficiency to prevent permanent damage to the optic nerve. Patients with VitB12 deficiency should have a baseline fundoscopic exam to rule out subclinical optic nerve damage. Moreover, patients who present with visual disturbances should be screened for VitB12 deficiency, especially the vegan population.

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Section: Discussionmentioning

confidence: 99%

Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report

Ata

Bilal

Javed

et al. 2020

Annals of Medicine and Surgery

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“…There is then vitamin B6 and when intensities of this vital B vitamin are excessively little, at that time there might be observed scaly, oleaginous eruptions on face or upper body. However, these are not the lone signs of B vitamin deficit, but there is a further wide-ranging list of vitamin B scarcity signs [47,48].…”

Section: Conditions and Causes Of B Vitamins Deficiencymentioning

confidence: 99%

Deficiency of Vitamin B-Complex and Its Relation with Body Disorders

Sarwar¹,

Sarwar²

2022

B-Complex Vitamins - Sources, Intakes and Novel Applications

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Vitamins B denote to some diverse kinds of vitamins which collectively, are recognized as B-complex vitamin. At hand are eight types of vitamins in vitamin B complex; thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9) also known as folic acid and cobalamin (B12). B vitamins have a direct impact on body energy levels, brain function and cell metabolism. There is a roundup of four top causes of vitamin B deficiency; a non-balanced diet, excessive alcohol consumption, various medications and gut malabsorption conditions. Deficiencies in these B vitamins can lead to a number of different symptoms like paresthesias, peripheral neuropathy, psychosis and heart attack and stroke over time if the deficiency is not reversed. Vitamins are found in highest abundance in meat, eggs and dairy or milk products such as butter, yogurt and cheese produced from milk of mammals usually buffaloes, cattle, goats, sheep and camels. Most people can get many nutrients they need, including B vitamins, by eating a varied diet of lean meats, grains, fruits and vegetables. This chapter provides an affluent of the most common types of vitamins B, including why body needs these, their deficiency symptoms and which foods contain them.

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“…The preclinical stage of deficiency, named sub-clinical deficiency, exhibits only non-specific symptoms [12] and often remains underdiagnosed with negative health impact in vulnerable groups, especially older adults [13]. The most frequent and evident clinical manifestations of B12 deficiency are megaloblastic anemia and neurological alterations (e.g., sensory and motor disturbances, particularly in the lower extremities, ataxia) [14]. Moreover, neurological disorders can occur in the absence of hematological manifestations [2].…”

Section: Prevalence Of Deficiencymentioning

confidence: 99%

Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population

et al. 2021

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Vitamin B12 (also known as cobalamin) is an essential water-soluble vitamin that plays a pivotal role for several physiologic functions during one’s lifespan. Only certain microorganisms are able to synthetize B12, thus humans obtain cobalamin exclusively from their diet, specifically from animal-derived foods. Specific sub-group populations are at risk of vitamin B12 subclinical deficiency due to different factors including poor intake of animal source foods and age-dependent decrease in the capacity of intestinal B12 uptake. Consumption of animal products produces some negative health issues and negatively impacts sustainability while a plant-based diet increases the risk of B12 deficiency. Taking a cue from the aforementioned considerations, this narrative review aims to summarize facts about B12 deficiency and the burden of inadequate dietary intake in elderly population, as well as to discuss sustainable approaches to vitamin B12 deficiency in aging population.

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Deficiency of vitamin B12 and its relation with neurological disorders: a critical review

Cited by 39 publications

References 50 publications

Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report

Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report

Deficiency of Vitamin B-Complex and Its Relation with Body Disorders

Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population

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