Deficiency of Vitamin B12 in Hypothyroidism

Tudhope, G. R.; Wilson, G. M.

doi:10.1016/s0140-6736(62)91652-5

Cited by 95 publications

(23 citation statements)

References 19 publications

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“…Addisonian pernicious aneemia in its frank and latent forms is commoner among patients with spontaneous hypothyroidism than in control patients of comparable age and sex [Tudhope and Wilson, 1962] and patients with idiopathic adrenal insufficiency have a high incidence of thyroid disease in their previous history, at autopsy and among their relatives [Wells, 1930;Sloper, 1953; and c]. There is a high incidence of gastric parietal cell antibody in patients with Hashimoto thyroiditis, spontaneous hypothyroidism and thyrotoxicosis [Irvine et al, 1962;Taylor et al, 1962;Irvine, 1963 b;Irvine et al, 1964] and patients with idiopathic adrenal VOL.…”

Section: Discussionmentioning

confidence: 92%

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

Irvine

1964

Exp Physiol

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The immunological response to thyroid damage has been studied in the 101. thyrotoxic patients treated with radioactive iodine (1311). Patients who had positive titres of thyroid complement-fixing (CF) antibody in the sera before treatment invariably showed a rise in titre of this antibody commencing approximately 6 weeks after treatment but always falling to pre-treatment or lower levels after some months. Only in exceptional cases was there any formation of the thyroid CF antibody in patients who had negative thyroid CF tests before treatment; this was so even when the 1311 treatment was repeated on two, three or four occasions. In general, the change in thyroid CF titre was more pronounced than the change in titre of antibody to thyroglobulin.Although the epithelial cells of the human fectal thyroid are riclh in thyroid cytoplasmic antigen, the basement membrane is even more delicate than that noted in Hashimoto thyroiditis affecting the adult gland.A preliminary study has been made of the thymus in Hashimoto thyroiditis. Numerous germinal centres were observed in a thymic biopsy in one case and the radiological appearances of an enlarged thymus were noted in two others.These several findings are considered in terms of the possible meclhanisms of auto-inununity and the view is taken that formation of thyroid auto-antibodies is a result of a genetically determined disorder of immunological tolerance.

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Section: Discussionmentioning

confidence: 92%

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

Irvine

1964

Exp Physiol

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“…[7][8][9][10][11][12]14,26 Although these reports mainly dealt with PA, the presence of an iron-deficient microcytic anemia has also been described in patients with AITD 27 and even in patients with ABG, 4,14 the latter finding being in keeping with a hypochlorhydria-related iron deficiency. 28 Screening for the presence of anemia was, therefore, carried out in all patients and, indeed, was detected in 27 (43%) of 62 patients ( Table 3).…”

Section: Plasmamentioning

confidence: 99%

Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

Centanni¹,

Marignani²,

Gargano³

et al. 1999

Arch Intern Med

156

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“…These data strongly suggest that our patients showed a tendency to reduction in acid production in comparison with normal subjects. Tudhope and Wilson (1962) found that almost 50% of their patients with primary myxoedema had achlorhydria. Irvine (1965) studied gastric secretion in a group of 73 patients with 'chronic thyroiditis' and found that 62 had maximal acid output levels below 10 mEq./hour, while 30 had achlorhydria.…”

Section: Resultsmentioning

confidence: 99%