Deficiency of vitamin D and vitamin C in the pathogenesis of bronchial asthma

Ginter, E; Simko, V.

doi:10.4149/bll_2016_060

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Moreover, vitamin E has been related with spirometric indices of lung function in children with moderate asthma [25]. Similar findings have been reported for adults [26,27]. Carotenoids and, especially, lycopene and flavonoids, are some more antioxidant compounds found in high concentrations in fruits and vegetables.…”

Section: Discussionsupporting

confidence: 60%

Exploring the Relation between Atopic Diseases and Lifestyle Patterns among Adolescents Living in Greece: Evidence from the Greek Global Asthma Network (GAN) Cross-Sectional Study

et al. 2021

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Introduction: Diet and physical activity might be associated with the risk of allergic diseases in childhood. However, evidence in literature is sparse and diverse. We aim to examine the associations between four healthy dietary consumption pattern drinks, plus the adherence to a physically active lifestyle with atopic diseases (asthma, allergic rhinitis and eczema) in adolescence and their relative importance. Methods: A total of 1934 adolescents (921 boys, 47.5%) and their parents completed a validated questionnaire assessing atopic diseases’ symptoms prevalence in the past 12 months, as well as nutritional and physical activity information. Four healthy dietary and one physical active lifestyle patterns were identified and logistic regression was applied to assess their relation with allergic diseases. Results: A high weekly consumption of fruits, vegetables and pulses and low consumption of unhealthy foods was negatively associated with all atopic symptoms while adherence to a physical active lifestyle was inversely associated with asthma and allergic rhinitis symptoms and dairy products with asthma and eczema symptoms in the past 12 months after adjustment for several confounders (all p < 0.05). Fruits, vegetables and pulses consumption per week emerged as the most important lifestyle pattern negatively associated for all atopic diseases, after the adjustment for all the remaining lifestyle patterns and confounders (all p < 0.05) Conclusions: Our findings suggest that a high fruit, vegetable and pulse intake should be the first lifestyle intervention every clinician and public health care worker evolving in the management of atopic adolescents should encourage and promote.

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Section: Discussionsupporting

confidence: 60%

Exploring the Relation between Atopic Diseases and Lifestyle Patterns among Adolescents Living in Greece: Evidence from the Greek Global Asthma Network (GAN) Cross-Sectional Study

et al. 2021

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“…Although the supplementation of various antioxidants appears to be a promising adjuvant therapy for asthma, various studies did not confirm the significant benefits over standard therapy. The potential of antioxidant therapy could be improved by taking into consideration individual characteristics of each particular asthmatic (e.g., the presence of various polymorphisms in the genes for antioxidant enzymes) and environmental risk factors, instead of treating oxidative stress in the airways broadly (12, 41). …”

Section: Antioxidant Strategies For Asthma Treatmentmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

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Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

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“…Vitamin D regulates calcium and phosphorus balance and bone metabolism. In addition, the latest research shows that it also has important immunomodulatory effects, which inhibit airway inflammation, improve AHR, reduce gland secretion, reduce the proliferation of bronchial smooth muscle cells, improve airway remodeling, and increase the body's response to hormones (Britt et al, 2016;Ginter & Simko, 2016). As researchers continue to study the pathogenesis of asthma, recent epidemiological studies have found that deficiency of vitamin D can lead to the occurrence of various lung diseases (Britt et al, 2016).…”

Section: Introductionmentioning

confidence: 99%