Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma

Baraldo, Simonetta; Contoli, Marco; Bazzan, Erica; Turato, Graziella; Padovani, Anna; Marku, Brunilda; Calabrese, Fiorella; Caramori, Gaetano; Ballarin, Andrea; Snijders, Deborah; Barbato, Angelo; Saetta, Marina; Papi, Alberto

doi:10.1016/j.jaci.2012.08.005

Cited by 175 publications

(193 citation statements)

References 42 publications

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“…We hypothesized that atopy, particularly to indoor allergens, would be associated with increased antigen‐induced Th2‐like cytokine responses, and that these responses would be especially prominent in women with allergic asthma. We also expected that asthma in this population would be associated with deficient Th1‐like cytokine (IFN‐γ and IL‐12p40) and reduced type 1 interferon responses in response to viral and microbial stimuli, as reported in other studies 18, 19, 20.…”

Section: Introductionmentioning

confidence: 74%

The influence of atopy and asthma on immune responses in inner‐city adults

Kakumanu

Jaffee

Visness

et al. 2016

Immunity, Inflammation and Disease

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Asthma in the inner‐city population is usually atopic in nature, and is associated with significant morbidity and mortality. However, the underlying immune abnormalities that underlie asthma in urban adults have not been well defined. We investigated the influence of atopy and asthma on cytokine responses of inner‐city adult women to define immune abnormalities associated with asthma and atopy. Blood samples were collected from 509 of 606 inner‐city women enrolled in the Urban Environment and Childhood Asthma (URECA) study. We tested for associations between atopy and asthma status and cytokine responses in peripheral blood mononuclear cells incubated ex vivo with a panel of innate and adaptive immune stimulants. Atopic subjects had heightened Th2 cytokine responses (IL‐4, IL‐5, IL‐13) to cockroach and dust mite antigens, tetanus toxoid, and phytohemagglutinin (P < 0.05 for all). Differences in cytokine responses were greatest in response to stimulation with cockroach and dust mite. In a multivariate analysis, atopy was broadly related to increased Th2‐like responses to all antigens and PHA, while asthma was only weakly related to mitogen‐induced IL‐4 and IL‐5 responses. There were few asthma or allergy‐related differences in responses to innate stimuli, including IFN‐α and IFN‐γ responses. In this inner‐city adult female population, atopy is associated with enhanced Th2 responses to allergens and other stimuli, and there was little or no additional signal attributable to asthma. In particular, these data indicate that altered systemic interferon and innate immune responses are not associated with allergies and/or asthma in inner‐city women.

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Section: Introductionmentioning

confidence: 74%

The influence of atopy and asthma on immune responses in inner‐city adults

Kakumanu

Jaffee

Visness

et al. 2016

Immunity, Inflammation and Disease

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“…Se ha demostrado que la IL-25 producida por las células epiteliales juega un rol clave en la inducción de una respuesta inflamatoria tipo Th2 después de las infecciones virales 34 , aunque se ha encontrado que la sensibilización alérgica se asocia positivamente con el rinovirus y no con otros virus 35 . Recientemente, Baraldo et al 36 en un estudio inmunohistoquímico de biopsias bronquiales de niños, demostraron que los asmáticos (atópicos y no atópicos) y los atópicos (sin asma) tienen como factor común una baja producción de interferón gamma frente a infecciones por rinovirus.…”

Section: Discussionunclassified

Prevalencia y perfil de sensibilización a aeroalérgenos en 1.199 niños asmáticos: serie consecutiva de casos

et al. 2014

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“…EDWARDS et al [8] showed that bronchial epithelial cells from atopic asthmatic children had impaired interferon-β and -γ levels in response to rhinoviruses infection. A deficient production of interferon by bronchial epithelial cells in response to rhinoviruses was found not only in atopic and non-atopic asthmatics, but also in atopic controls [9], thus suggesting that the impaired immune response of the epithelium after viral infection was more likely related to the T-helper cell type 2 inflammatory pattern in the airways than to intrinsic characteristic of asthma.…”

Section: Respiratory Tract Infections In Early Life and Later Asthmamentioning

confidence: 96%

Asthma in childhood

Benedictis

Attanasi

2016

Eur Respir Rev

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Several topics on childhood asthma were addressed in the Paediatric Clinical Year in Review session at the 2015 European Respiratory Society International Congress. With regard to the relationship between lower respiratory tract infections and asthma, it emerges that is the number of respiratory episodes in the first years of life, but not the particular viral trigger, to be associated with later asthma development. Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma. @ERSpublications New research reports must be integrated into medical communication to assist clinicians to improve asthma management http://ow.ly/XACHS

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Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma

Cited by 175 publications

References 42 publications

The influence of atopy and asthma on immune responses in inner‐city adults

The influence of atopy and asthma on immune responses in inner‐city adults

Prevalencia y perfil de sensibilización a aeroalérgenos en 1.199 niños asmáticos: serie consecutiva de casos

Asthma in childhood

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