Deficient attention modulation of lateralized alpha power in schizophrenia

Kustermann, Thomas; Rockstroh, Brigitte; Kienle, Johanna; Miller, Gregory A.; Popov, Tzvetan

doi:10.1111/psyp.12626

Cited by 17 publications

(7 citation statements)

References 81 publications

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“…These results expand upon recent work that found impaired lateralized alpha suppression during a task of visuospatial attention and WM in PSZ (31). That study suggested that poor spatial memory for the cue location was a consequence of impoverished alpha modulation in patients; here, we extend these results by revealing that suppression abnormalities can be observed during feature-based memory tasks as well.…”

Section: Discussionsupporting

confidence: 88%

Impaired Suppression of Delay-Period Alpha and Beta Is Associated With Impaired Working Memory in Schizophrenia

Erickson

Albrecht

Robinson

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Although people with schizophrenia (PSZ) frequently exhibit reduced working memory capacity relative to healthy comparison subjects (HCS), the mechanisms that underlie this impairment are not yet known. The present study aimed to assess one putative mechanism: impaired suppression of alpha and beta frequency bands during the delay period of a visual working memory task. Methods The electroencephalogram (EEG) was recorded from 30 PSZ and 31 HCS while they completed a change detection task in which they were required to remember a briefly presented array of colored squares over an 1800-ms delay interval. Results Overall, we found that PSZ had significantly reduced alpha and beta-band suppression during the delay interval compared to HCS, and that these significant differences emerged early (100-200 ms after the onset of the memory array). Furthermore, the magnitude of suppression was significantly associated with task performance across both groups. Finally, the magnitude of suppression in alpha and beta frequency bands was significantly associated with a range of cognitive measures among HCS, but not PSZ. Conclusions These results implicate impaired alpha/beta suppression during the consolidation period of working memory tasks as a promising neural mechanism that constrains capacity in PSZ.

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Section: Discussionsupporting

confidence: 88%

Impaired Suppression of Delay-Period Alpha and Beta Is Associated With Impaired Working Memory in Schizophrenia

Erickson

Albrecht

Robinson

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…CAS differences between groups begin~300 ms after onset of the memory array and persist throughout the delay period in healthy subjects, but not FESz. This extends upon previous findings of reduced CAS during visual attention in long-term schizophrenia (30), and has strong implications for previous findings of reduced delay period activity, despite no difference in encoding and orienting of attention. Visual objects maintained in vSTM are quickly bound with their spatial locations into an internalized visual scene after sensation (~100-200 ms) and attention selection/orienting (~250-400 ms) (62).…”

Section: Discussionsupporting

confidence: 88%

“…Reduced CAS during covert visual attention (30) and reduced (non-lateralized) alpha suppression during vSTM maintenance (22) have been reported in long-term schizophrenia. However, schizophrenia-related deficits in CAS have not been assessed during vSTM maintenance, and CAS deficits have not been reported early in the disease course.…”

Section: Introductionmentioning

confidence: 90%

Reduced Dorsal Visual Oscillatory Activity During Working Memory Maintenance in the First-Episode Schizophrenia Spectrum

et al. 2020

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Cognitive deficits in people with schizophrenia are among the hardest to treat and strongly predict functional outcome. The ability to maintain sensory precepts in memory over a short delay is impacted early in the progression of schizophrenia and has been linked to reliable neurophysiological markers. Yet, little is known about the mechanisms of these deficits. Here, we investigated possible neurophysiological mechanisms of impaired visual short-term memory (vSTM, aka working memory maintenance) in the first-episode schizophrenia spectrum (FESz) using magnetoencephalography (MEG). Twenty-eight FESz and 25 matched controls performed a lateralized change detection task where they were cued to selectively attend and remember colors of circles presented in either the left or right peripheral visual field over a 1 s delay. Contralateral alpha suppression (CAS) during the delay period was used to assess selective attention to cued visual hemifields held in vSTM. Delay-period CAS was compared between FESz and controls and between trials presenting one vs three items per visual hemifield. CAS in dorsal visual cortex was reduced in FESz compared to controls in high-load trials, but not low-load trials. Group differences in CAS were found beginning 100 ms after the disappearance of the memory set, suggesting deficits were not due to the initial deployment of attention to the cued visual hemifield prior to stimulus presentation. CAS was not greater for high-load vs lowload trials in FESz subjects, although this effect was prominent in controls. Further, lateralized gamma (34-40 Hz) power emerged in dorsal visual cortex prior to the onset of CAS in controls but not FESz. Gamma power in this cluster differed between groups at both high and low load. CAS deficits observed in FESz were correlated with change detection accuracy, working memory function, estimated IQ, and negative symptoms. Our results implicate deficits in CAS in trials requiring broad, but not narrow, focus of attention to spatially distributed objects maintained in vSTM in FESz, possibly due to reduced ability to broadly distribute visuospatial attention (alpha) or disruption of

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“… 36 Alternatively, it has been suggested that deficits in alpha oscillation in patients with psychosis reflect deficits in attention allocation and visual information processing. 18 , 37 It should be noted that alpha-ERS in the left fronto-central region was significantly larger than that in the right fronto-central region in our study. A possible explanation for this result is the frontal alpha asymmetry.…”

Section: Discussioncontrasting

confidence: 48%

Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis

Zhang,

Yang,

et al. 2024

BJPsych open

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Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.

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Deficient attention modulation of lateralized alpha power in schizophrenia

Cited by 17 publications

References 81 publications

Impaired Suppression of Delay-Period Alpha and Beta Is Associated With Impaired Working Memory in Schizophrenia

Impaired Suppression of Delay-Period Alpha and Beta Is Associated With Impaired Working Memory in Schizophrenia

Reduced Dorsal Visual Oscillatory Activity During Working Memory Maintenance in the First-Episode Schizophrenia Spectrum

Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis

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