Deficient Calcitonin Response to Calcium Stimulation in Postmenopausal Osteoporosis?

Taggart, H.; Chesnut, Charles H.; Ivey, Joel L.; Sisom, Karen; Baylink, David J.; Huber, Monika; Roos, Bernard A.

doi:10.1016/s0140-6736(82)91451-9

Cited by 98 publications

(28 citation statements)

References 8 publications

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“…Although the correlation between CT plasma level and BMD remains unclear (Chesnut et al 1980;Leggate et al 1984;Prince et al 1989), we can speculate that a variation in the CT locus may be correlated to variations in the effect of CT in maintaining calcium homeostasis. For example, the CT secretory reaction to calcium infusion in osteoporotic women was reported to be lower than that in normal women (Taggart et al 1982). In addition, it was reported that CT secretion response decreased with aging (Deftos et al 1980).…”

Section: Discussionmentioning

confidence: 99%

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

et al. 2000

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Calcitonin (CT), a calcium-regulating hormone, lowers the calcium level in serum by inhibiting bone resorption. Because CT may play a role in the pathogenesis of osteoporosis, genetic variations in or adjacent to the CT gene may be associated with variations in bone mineral density (BMD). The present study examined the correlation between a dinucleotide (cytosine-adenine; CA) repeat polymorphism at the CT locus and BMD in 311 Japanese postmenopausal women (mean age, 64.1 years). Seven alleles were present in this population; each allele contained 10, 11, 16, 17, 18, 19, or 20 CA repeats. Thus, we designated the respective genotypes A10, A11, A16, A17, A18, A19, and A20. The A10 and A17 alleles were the predominant alleles in the population studied. Z scores (a parameter representing deviation from the age-specific weight-adjusted average BMD) were compared between individuals that possessed one or two alleles of each genotype and those that did not possess the allele. Subjects who possessed one or two A10 alleles had lower BMD Z scores than those who did not (lumbar 2-4 BMD Z score; Ϫ0.148 Ϯ 1.23 vs 0.182 Ϯ 1.54; P ϭ 0.04). No significant relationships were observed between allelic status and background data or biochemical parameters. The significant association observed between BMD and genetic variations at the CT locus implies that polymorphism at this locus may be a useful marker for the genetic study of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

et al. 2000

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“…CT is also involved in reducing elevated serum calcium levels in conditions associated with hypercalcemia and possibly after intestinal absorption of calcium (3,12,167). Decreased immunoreactive CT (i-CT) concentrations in the circulation and decreased CT reserves in the C cells have been shown to follow ovarian failure (168)(169)(170). Increased serum i-CT levels have been shown to follow exogenous administration of estrogen, but this view is not universally accepted (171,172).…”

Section: Calcitoninmentioning

confidence: 99%

“…CGRP receptors are widely distributed in the brain and spinal cord (169)(170)(171)(172)(173)(174) where this peptide performs a range of important functions (1,144,414,505). A variety of evidence suggests that CGRP acts as a neuromodulator at neuromuscular junction/motor end-plates.…”

Section: Vol 17 Nomentioning

confidence: 99%

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials

Wimalawansa¹

1996

Endocrine Reviews

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“…A reflection of this role is the increased circulating level of the peptide at these times Stevenson, Hillyard, MacIntyre, Cooper & Whitehead, 1979). Conversely, there is evidence that failure of ovarian function at the menopause (whether natural or artificial) is followed by a fall in circulating calcitonin levels accompanied by evidence of increased osteoclastic activity (Stevenson, MacIntyre & Whitehead, 1982;Taggert, Chesnut, Ivey, Baylink, Sisom, Huber & Roos, 1982). Certainly, the reversal of the fall in circulating calcitonin levels (Morimoto, Tsuji, Okada, Onishi & Kumahara, 1980;Stevenson, Abeyasekera, Hillyard, Phang, MacIntyre, Campbell, Lane, Townsend, Young & Whitehead, 1983) by oestrogen administration and the evidence that calcitonin can inhibit postmenopausal bone loss suggests that the hormone has a normal physiological role in maintaining skeletal integrity.…”

Section: Calcitoninmentioning

confidence: 99%

Biology of Peptides From the Calcitonin Genes

1987

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Despite being products from the same gene, there is clearly a marked divergence in the distribution and physiological role of calcitonin and CGRP. Whereas calcitonin is predominantly distributed in the thyroid, CGRP is abundant in the nervous system throughout the body. Though the peptides have only weak structural homologies, a generally similar conformation enables them to interact at each other's receptors. Hence the pharmacological effects of the peptides faintly resemble one another. Calcitonin receptors are mainly found on osteoclasts and at certain sites in the nervous system. CGRP binding sites are abundant in the cerebellum and blood vessels. Calcitonin is a circulating hormone controlling osteoclastic activity. CGRP acts as a neurotransmitter or neuromodulator centrally, and released from perivascular nerve terminals, it modulates arteriolar tone. Released from motoneurones, CGRP may also play a trophic role regulating the muscle acetylcholine receptor state. The next decade should establish the physiological role of CGRP and the regulation of the expression of the calcitonin/CGRP gene complex.

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Deficient Calcitonin Response to Calcium Stimulation in Postmenopausal Osteoporosis?

Cited by 98 publications

References 8 publications

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials

Biology of Peptides From the Calcitonin Genes

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