Deficient Zinc Levels and Myocardial Infarction

Abstract

The purpose of this study is to clarify the association between Zn levels and myocardial infarction (MI) using a meta-analysis approach. We searched articles in the PubMed, OVID, and ScienceDirect published as of November 2014. Thirteen eligible articles with 2886 subjects from 41 case-control studies were identified. Overall, pooled analysis indicated that subjects with MI had lower Zn levels than healthy controls (standardized mean difference (SMD) = -1.848, 95 % confidence interval (CI) = [-2.365, -1.331]). Further subgroup analysis found that subjects with MI had lower Zn levels than healthy controls in serum (SMD = -1.764, 95 % CI = [-2.417, -1.112]) and hair (SMD = -3.326, 95 % CI = [-4.616, -2.036]), but not in toenail (SMD = -0.396, 95 % CI = [-1.114, 0.322]). The subgroup analysis stratified by type of Zn measurement found a similar pattern in inductively coupled plasma-atomic absorption spectrometry (ICP-AAS) (SMD = -2.442, 95 % CI = [-3.092, -1.753]), but not in neutron activation analysis (NAA) (SMD = -0.449, 95 % CI = [-1.127, 0.230]). Lower Zn levels in MI patients were found both in male (SMD = -3.350, 95 % CI = [-4.531, -2.169]) and female (SMD = -2.681, 95 % CI = [-3.440, -1.922]). And the difference of Zn levels according to MI in Asia (SMD = -2.555, 95 % CI = [-3.267, -1.844]) was greater to that among the population in Europe (SMD = -0.745, 95 % CI = [-1.386, -0.104]), but no difference was found in Oceania (SMD = -0.255, 95 % CI = [-0.600, 0.089]). In conclusion, this meta-analysis indicates that there is a significant association between Zn deficiency and MI. We suggest that a community-based, long-term observation in a cohort design should be performed to obtain better understanding of causal relationships between Zn and MI, through measuring hair Zn at baseline to investigate whether the highest zinc category versus lowest was associated with MI risk.

Short-Term Inhalation of Ultrafine Zinc Particles Could Alleviate Cardiac Dysfunctions in Rats of Myocardial Infarction

“…A meta-analysis indicated a significant association between zinc deficiency and MI (Liu et al, 2015). The short-term inhalation of ultrafine zinc particles alleviated myocardial dysfunctions and slowed down conversion of MI to heart failure in MI rats, which agreed with previous studies that EF increased with Zn content (Oster et al, 1993) and Zn supplementation to a cardioplegic solution reversed the loss of systolic function (Powell et al, 1995).…”

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases

“…Thus, it has been suggested that serum zinc is a reliable diagnostic indicator for acute MI, and the extent of the fall has prognostic implications. In a meta-analysis with 2886 subjects from 41 case-control studies, the authors revealed that the subjects with MI had lower zinc levels in serum and hair than healthy controls 68 . Moreover, a recent study using zinc quartiles also demonstrated a significant inverse correlation between serum zinc levels and serum creatine kinase (CK), CK-MB, and cardiac troponin T levels 69 .…”

Assessment of Concentrations of Heavy Metals in Postmyocardial Infarction Patients and Patients Free from Cardiovascular Event

“…Improper zinc homeostasis is associated with the development of cardiovascular diseases [29]. Liu et al [30] conducted a meta-analysis aimed at assessing the relationship between Zn concentration in the body and the occurrence of MI. e results of 13 publications proved that patients with acute MI had lower Zn concentration than the control group.…”