Déficit de vitamina D y densidad mineral ósea en la enfermedad de Crohn

Sánchez‐Cano, Daniel; Ruiz‐Villaverde, Ricardo; Callejas‐Rubio, José Luis; Pérez, Carlos Cárdeña; García, María Gómez; Ortego-Centeno, Norbérto

doi:10.1016/j.medcli.2010.09.032

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…However, the prevalence of vitamin D insufficiency in patients with SSc probably would not be different from that of the general population. Our group found a similar prevalence in postmenopausal women, premenopausal asthmatic women, and patients with diabetes and Crohn's disease 7 . The question of interest is the relationship of vitamin D insufficiency with clinical manifestations and the course of the disease.…”

Section: Dr Rios Fernández Et Al Replysupporting

confidence: 73%

Dr. Rios Fernández, et al, reply

Fernández¹,

Callejas‐Rubio²,

Fernández-Roldán³

et al. 2011

J Rheumatol

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Section: Dr Rios Fernández Et Al Replysupporting

confidence: 73%

Dr. Rios Fernández, et al, reply

Fernández¹,

Callejas‐Rubio²,

Fernández-Roldán³

et al. 2011

J Rheumatol

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“…A cross-sectional study that was also undertaken in Spain examined the relation between vitamin D deficiency and bone mineral density in 64 patients with CD. There was a deficiency prevalence of 60% (5). However, the reduced sample size and the absence of information about the season during which the measurements were taken or the percentage of patients with clinical activity hindered a comparison with our findings.…”

Section: Discussionmentioning

confidence: 62%

“…A recent meta-analysis showed that the prevalence is also greater than that found in a healthy population (4). Prevalence data on vitamin D deficiency in patients with IBD are scarce in Spain (5). A few observational, heterogeneous or cross-sectional studies have attempted to determine the association between vitamin D deficiency and clinical and prognostic variables of IBD (clinical disease activity, quality of life, hospitalization or need for surgery).…”

mentioning

confidence: 99%

Vitamin D deficiency in outpatients with inflammatory bowel disease: prevalence and association with clinical-biological activity

Molero

et al. 2018

Rev Esp Enferm Dig

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Introduction: there are few data on the prevalence of vitamin D deficiency in patients with inflammatory bowel disease (IBD) in Spain. A deficiency could be associated with a worse course of the disease. Aim: to determine the prevalence of 25-hydroxyvitamin D (25OHD) deficiency in a cohort of outpatients with IBD and assess its association with clinical and biological activity, quality of life and psychological symptoms. Methods: a cross-sectional, single-center observational study was performed. The study variables were obtained via clinical interviews, medical chart review and validated questionnaires (Hospital Anxiety and Depression Scale and Short Quality of Life in Inflammatory Bowel Disease Questionnaire). 25OHD was measured in the same laboratory by an electro-chemiluminescence immunoassay. Results: the study included 224 patients. The prevalence of vitamin D deficiency in Crohn's disease and ulcerative colitis was 33.3% and 20.3%, respectively. In Crohn's disease, vitamin D deficiency was associated with a higher clinical activity (p < 0.001) and a higher concentration of fecal calprotectin (p = 0.01). In ulcerative colitis, it was associated with clinical activity (p < 0.001), the use of steroids during the last six months (p = 0.001) and hospital admission during the previous year (p = 0.003). A subanalysis of 149 patients failed to detect an association between vitamin D and quality of life or the scores of the Hospital Anxiety and Depression Scale. Conclusions: vitamin D deficiency is common in patients with inflammatory bowel disease. An association was found between vitamin D concentration and clinical activity indexes, as well as fecal calprotectin levels in Crohn's disease.

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“…Both osteocalcin and CTX may be elevated in osteoporosis, osteopenia, hyperthyroidism, and parathyroidism. So far, there has not been much research regarding bone mineral alterations of IBD patients, and the literature is mixed about bone turnover markers, including whether osteocalcin is elevated, normal, or reduced [29][30][31][32][33][34]. Bischoff et al reported that osteocalcin was lower in 26% of patients, whereas another resorption parameter-the carboxyterminal cross-linked telopeptide of type I collagen (ICTP)-was elevated in 38% of IBD patients [13].…”

Section: Discussionmentioning

confidence: 99%

Bone Metabolism Alteration in Patients with Inflammatory Bowel Disease

Tulewicz-Marti

Lewandowski

Rydzewska

2022

JCM

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Background: Metabolic bone disease is a common disorder, but there is a lack of data on it in patients with inflammatory bowel disease (IBD). Methods: In this prospective, one-centre study, we assessed bone mineral and vitamin D alterations in 187 IBD patients (119 with Crohn’s disease (CD) and 68 with ulcerative colitis (UC)). Results: While 81.3% of the patients had vitamin D deficiency, 14.2% of them had a severe deficiency. Elevated serum PTH concentrations were found in 14.9% of the patients. Only in 4.1% of cases was there an elevated level of a serum marker for bone formation (osteocalcin), whereas in 14.4% of cases, the bone resorption marker (CTX) was raised. The concentration of phosphate in urine was higher in the CD than in the UC group (51.20 vs. 31.25; p = 0.003). PTH was negatively associated with vitamin D level. Among the patients receiving corticosteroids, the CTX and CRP median levels were higher (0.49 vs. 0.38; p = 0.013 and 6.45 vs. 2.2; p = 0.029, respectively) compared with the group who did not receive them. Urine phosphate levels were lower (48.60 vs. 26.00; p = 0.005), as were osteocalcin (15.50 vs. 23.80; p < 0.001), and PTH (29.05 vs. 36.05; p = 0.018). Conclusions: Bone mineral alterations were common in patients with IBD, mostly in the CD patients. This may be associated with poor absorption, making CD patients vulnerable to changes in bone mineralization. Vitamin D supplementation remains crucial, especially when taking corticosteroids.

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Déficit de vitamina D y densidad mineral ósea en la enfermedad de Crohn

Cited by 8 publications

References 9 publications

Dr. Rios Fernández, et al, reply

Dr. Rios Fernández, et al, reply

Vitamin D deficiency in outpatients with inflammatory bowel disease: prevalence and association with clinical-biological activity

Bone Metabolism Alteration in Patients with Inflammatory Bowel Disease

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