Déficit en fraction terminale du complément révélé dès le premier épisode d’infection invasive à méningocoque

Invasive meningococcal disease: Should the first episode prompt further investigation?

“…In recent years, an increasing number of studies advocate for complement deficiency screening after a first severe meningococcal infection, particularly in the presence of a rare serogroup 7–10 . Rameix‐Welti et al .…”

“…7 In recent years, an increasing number of studies advocate for complement deficiency screening after a first severe meningococcal infection, particularly in the presence of a rare serogroup. [7][8][9][10] Rameix-Welti et al proposed five criteria for systematic screening that seemed to have a good positive predictive value, though still lacking validation: IMD before the age of 6 months or after 5 years old, family history of infection by N. meningitidis, recurrent infection, fulminant meningitis and infection by a rare serogroup. 5 Additionally, the National Institute for Health and Care Excellence (NICE) recommends testing for complement deficiency in the presence of 1 episode of invasive meningococcal disease caused by serogroups other than B.…”