Deficit in Memory Consolidation (Abnormal Forgetting Rate) in Childhood Temporal Lobe Epilepsy. Pre and Postoperative Long-Term Observation

Cronel-Ohayon, Stéphany; Zesiger, Pascal; Davidoff, V.; Boni, Antonella; Roulet, E.; Deonna, Thierry

doi:10.1055/s-2007-964997

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…apparently demonstrated AF, including an autobiographical memory deficit according to his mother's report, about 1.5 years before his seizure disorder began at age nine. Cronel-Ohayon et al (2006) suggested that J.E. 's documented AF for test stimuli paired with his retrograde memory deficit suggests the presence of a consolidation deficit and, consistent with McClelland et al (1995), that there are distinct subsystems with different timeframes within the consolidation process.…”

Section: Accelerated Forgetting Summarymentioning

confidence: 74%

“…This slowly developing form of amnesia, dubbed long term amnesia (Kapur 1996) or accelerated forgetting (AF), does not simply constitute a mild form of the classical global amnesia syndrome (Mayes et al 2003). Five case studies have described AF over extended delays in patients with TLE (Cronel-Ohayon et al 2006;Holdstock et al 2002;Kapur et al 1997;Lucchelli and Spinnler 1998;O'Connor et al 1997;see also De Renzi and Lucchelli 1994). There also are seven group studies that examined memory after long delays in adult TLE patients (Bell 2006;Bell et al 2005;Blake et al 2000;Giovagnoli et al 1995;Helmstaedter et al 1998;Mameniskiene et al 2006;Martin et al 1991).…”

Section: Accelerated Forgettingmentioning

confidence: 99%

“…'s memory for some events resisted degradation for up to 4 weeks. Cronel-Ohayon et al (2006) reported the interesting case of a boy, J.E., who they followed between ages nine and 18. His early childhood was completely normal.…”

Section: Case Studiesmentioning

confidence: 99%

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Recent Innovative Studies of Memory in Temporal Lobe Epilepsy

Bell

Giovagnoli

2007

Neuropsychol Rev

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Investigations of patients with temporal lobe epilepsy continue to result in significant advancements in the neuroscience of human memory, as they have for over 50 years. Recent reviews describing the state of the art in the clinical neuropsychology of TLE generally have emphasized (1) lateralization of cognitive deficits and the material-specific model of memory and/or (2) the relationships among pre- and post-surgery performance on standardized measures of anterograde memory, demographic and epilepsy variables and neuroimaging, neuropathology, and neurosurgery data. As information continues to accumulate about the pattern of performance on standard laboratory memory tests and the implications of these data before and after anterior temporal lobectomy for the treatment of TLE, innovative assessment techniques also are increasingly being applied. This review focuses on English language publications that addressed selected novel topics in adult TLE memory research. These topics are: (1) remote memory; (2) accelerated forgetting or long term amnesia; and (3) lateral versus mesial temporal lobe contributions to memory.

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Section: Accelerated Forgetting Summarymentioning

confidence: 74%

Section: Accelerated Forgettingmentioning

confidence: 99%

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Recent Innovative Studies of Memory in Temporal Lobe Epilepsy

Bell

Giovagnoli

2007

Neuropsychol Rev

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“…Moreover, some studies did not report learning performance (Dewar, Hoefeijzers, Zeman, Butler, & Della Sala, 2015;Gallassi et al, 2011;Hoefeijzers, Dewar, Dalla Sala, Butler, & Zeman, 2014;Jansari, Davis, McGibbon, Firminger, & Kapur, 2010;Lah, Mohamed, Thayer, Miller, & Diamond, 2014;McGibbon & Jansari, 2013;Narayanan et al, 2012;O'Connor, Sieggreen, Ahern, Schomer, & Mesulam, 1997;Ricci, Mohamed, Savage, Boserio, & Miller, 2015;Tramoni et al, 2011). In others, learning performance was not equated (Bell, 2006;Bell, Fine, Dow, Seidenberg, & Hermann, 2005;Cronel-Ohayon et al, 2006;Giovagnoli, Casazza, & Avanzini, 1995;Holdstock, Mayes, Isaac, Gong, & Roberts, 2002;Lucchelli & Spinnler, 1998;Mameniskiene et al, 2006;Mayes et al, 2003). These omissions or oversights limit the implications of these studies, as the role of subtle acquisition deficits cannot be excluded.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 98%

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Cassel

Morris

Koutroumanidis

et al. 2016

Cortex

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The notion of 'accelerated long-term forgetting' has often been attributed to disrupted 'late' memory consolidation. Nevertheless, methodological issues in the literature have left this theory unproven, leading some to suggest such findings may be reflective of subtle acquisition or early retention deficits. This study attempts to address such issues, and also to explore which pathophysiological variables are associated with forgetting rates. Eighteen participants with temporal lobe epilepsy (TLE) and eighteen matched controls completed background neuropsychological measurement of immediate and short-delay memory that showed comparable performance, both on verbal and visual tests. Using two novel experimental tasks to measure long-term forgetting, cued recall of verbal and visuospatial material was tested 30 seconds, 10 minutes, one day, and one week after learning. Forgetting of verbal material was found to be progressively faster during the course of a week in the TLE group. For visuospatial memory, participants in the TLE group exhibited faster early forgetting in the first 10 minutes after learning, as indicated by planned comparisons, with comparable forgetting rates thereafter. Our findings provide evidence for two patterns of disruption to 'early' memory consolidation in this population, occurring either at the initial delay only or continuing progressively through time. Differences in how soon after learning accelerated forgetting was detectable were related to factors associated with greater severity of epilepsy, such as presence of medial temporal lobe sclerosis on MRI and use of multiple anti-epileptic agents.

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“…Yet, there is evidence that both short-term working memory and long-term reference memory can be impaired in patients with hippocampal damage (Abrahams et al, 1999). Indeed, recent animal research has gone further in suggesting that the two types of memory can be dissociated (Sanderson et al, 2009;Rust et al, 2010), and the epilepsy literature is increasingly showing an inability to retain learned memories over a long period of time, a phenomenon referred to as accelerated forgetting (Blake et al, 2000;Cronel-Ohayon et al, 2006;Bell and Giovagnoli, 2007;). …”

Section: Introductionmentioning

confidence: 99%

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

Barkas

Redhead

Taylor

et al. 2012

Brain

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Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these patients. We have demonstrated impairments in the acquisition of an allocentric spatial task, in patients with unilateral hippocampal sclerosis. We also show that patients have accelerated forgetting of the learned spatial task and that this is associated with damage to the non-dominant hippocampal formation. We go on to show a very similar pattern of chronic allocentric learning and accelerated forgetting in a status epilepticus model of mesial temporal lobe epilepsy in rats, which is associated with reduced and abnormal hippocampal neurogenesis. Finally, we show that reversal of the neurogenic deficit using fluoxetine is associated with reversal of the learning deficit but not the accelerated forgetting, pointing to a possible dissociation in the underlying mechanisms, as well as a potential therapeutic strategy for improving hippocampal-dependant learning in patients with mesial temporal lobe epilepsy.

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Deficit in Memory Consolidation (Abnormal Forgetting Rate) in Childhood Temporal Lobe Epilepsy. Pre and Postoperative Long-Term Observation

Cited by 17 publications

References 33 publications

Recent Innovative Studies of Memory in Temporal Lobe Epilepsy

Recent Innovative Studies of Memory in Temporal Lobe Epilepsy

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

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