Deficit of Female Sex Hormones Desensitizes Rat Cardiac Mitophagy

Kampaengsri, Theerachat; Ponpuak, Marisa; Wattanapermpool, Jonggonnee; Bupha-Intr, Tepmanas

doi:10.4103/cjp.cjp_102_20

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…There was widespread internal communication regarding these changes, and our AGs were updated on our hospital intranet and mobile app. 3…”

Section: Methodsmentioning

confidence: 99%

“…There was widespread internal communication regarding these changes, and our AGs were updated on our hospital intranet and mobile app. 3 Data extraction and creation of cohorts Medication dispensing at WRH/KPH uses BD Pyxis™, which permits data extraction for all individual dispensing events. The exception to this is the Emergency Department (ED), for which dispensing records were unavailable.…”

Section: Introductionmentioning

confidence: 99%

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A triple bottom line approach to antimicrobial stewardship: the effects of simplifying treatment

Balm,

Bupha-Intr,

Sinha

et al. 2023

Preprint

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AimOur antimicrobial guidelines (AGs) were changed in 2021 to recommend once-daily ceftriaxone in place of three-times-daily cefuroxime as preferred cephalosporin. This analysis sought to assess the effects of this on incidence ofClostridioides difficileinfection (CDI), third-generation cephalosporin resistant Enterobacterales (3GCR-E), and resource utilisation.MethodBefore and after analysis of 30-day CDI and 3GCR-E incidence following receipt of cefuroxime/ceftriaxone pre- and post-AG change. Total nursing time and waste production relating to cefuroxime/ceftriaxone delivery were calculated pre- and post-change.ResultsCDI incidence was 0.6% pre- and 1.0% post-change (adjusted odds ratio [aOR] 1.44, p=0.07) and 3GCR-E incidence 3.5% and 3.1% (aOR 0.90, p=0.33). Mean per-quarter estimated nursing administration time decreased from 2065 to 1163 hours (902 nurse-hour reduction) and antibiotic-related waste generation from 1131kg to 748kg (383kg reduction). Overall days of therapy per-quarter of cefuroxime/ceftriaxone were unchanged between periods.ConclusionThis simplification of our AG from a three-times-daily to a once-daily antibiotic resulted in considerable savings for our hospital (roughly 1.7 full-time equivalent nurses and over a tonne of waste yearly), with no significant increases in CDI or 3GCR-E. The impact of dosing schedules on non-antibiotic-spectrum factors, such nursing time and resource usage, is worthy of consideration when designing AGs.

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“…There was widespread internal communication regarding these changes, and our AGs were updated on our hospital intranet and mobile app. 3…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A triple bottom line approach to antimicrobial stewardship: the effects of simplifying treatment

Balm,

Bupha-Intr,

Sinha

et al. 2023

Preprint

View full text Add to dashboard Cite

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An update on the role of sex hormones in the function of the cardiorenal mitochondria

Shulha,

Shyshenko,

Schibalski

et al. 2024

Biochemical Society Transactions

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Multiple studies have highlighted the crucial role of mitochondrial bioenergetics in understanding the progression of cardiorenal diseases, revealing new potential treatment targets related to mitochondrial metabolism. There are well-established sexual dimorphisms in cardiac and renal physiology, with premenopausal females being generally protected from pathology compared with males. The mechanisms of this protection remain to be fully elucidated, however, they clearly depend, at least in part, on sex hormones. Sex hormones contribute to regulating mitochondrial function, and vice versa, highlighting the existence of a bidirectional relationship pivotal for cellular energy metabolism; however, there are still large gaps in knowledge when the sex differences in mitochondrial bioenergetics in health and disease are concerned. This manuscript provides an overview of the new evidence that has been accumulated regarding the role of sex hormones in renal and cardiac mitochondria-dependent cellular energetics, metabolism, and signaling, mainly focusing on the data obtained within the last 3–5 years. We briefly discuss mitochondrial function and different types of sex hormones for the reader and then focus on novel research underscoring the emerging mitochondrial pathways regulated by sex hormones, which might be of interest for the development of novel therapeutic strategies for cardiorenal conditions.

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Gender Differences in Levels of Steroid Hormones in Heart Cell Mitochondria at the Stages of B16/F10 Melanoma Development Combined With Chronic Neurogenic Pain

Frantsiyants¹,

Neskubina²,

Kaplieva³

et al. 2022

Crimea Journal of Experimental and Clinical Medicine

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Aim - an analysis of levels of steroid hormones in heart cell mitochondria at the stages of B16/F10 melanoma development in combination with chronic neurogenic pain in male and female C57BL/6 mice. The study included male and female C57BL/6 mice (n=336). Experimental groups were: intact animals (♂ n=21; ♀ n=21); controls (♂ n=21; ♀ n=21) with a model of chronic neurogenic pain (CNP); the comparison group (♂ n=63; ♀ n=63) with melanomas (B16/ F10); the main group (♂ n=63; ♀ n=63) (CNP+B16/F10) with melanoma transplanted 3 weeks after the CNP model creation. Levels of estradiol (pg/g protein), estrone (pg/g protein), progesterone (ng/g protein), total testosterone (ng/g protein), and free testosterone (pg/g protein) were determined by ELISA in mitochondrial samples. In animals with CNP, changes in levels of steroid hormones were detected only in heart mitochondria of female mice: estradiol was reduced by 4.6 times, estrone by 2.2 times, progesterone by 1.8 times (p˂0.05), and total testosterone by 2.4 times compared with intact values. Melanoma growth (3 weeks) in females downregulated levels of estradiol by 1.7 times (p˂0.05), estrone by 1.8 times (p˂0.05), progesterone by 2.1 times, and total testosterone by 2.3 times compared with intact values. In males, only total testosterone decreased by 2.1 times during the same period. Melanoma growth in presence of CNP (3 weeks) in females decreased levels of estradiol by 1.6 times (p˂0.05) compared with control val- ues, while males showed reduced levels of estradiol and total and free testosterone by 1.3 times (p˂0.05), 1.9 times (p˂0.05) and 2.7 times, respectively, as well as elevated levels of estrone by 1.6 times (p˂0.05). CNP and the growth of B16/F10 melanoma to a greater extent weaken the heart of females due to the involvement of a wider spectrum of hormones and a decrease in their levels in the heart mitochondria, compared to males. When CNP was combined with B16/F10 melanoma, a more significant hormonal imbalance was determined in males than in females.

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Deficit of Female Sex Hormones Desensitizes Rat Cardiac Mitophagy

Cited by 3 publications

References 25 publications

A triple bottom line approach to antimicrobial stewardship: the effects of simplifying treatment

A triple bottom line approach to antimicrobial stewardship: the effects of simplifying treatment

An update on the role of sex hormones in the function of the cardiorenal mitochondria

Gender Differences in Levels of Steroid Hormones in Heart Cell Mitochondria at the Stages of B16/F10 Melanoma Development Combined With Chronic Neurogenic Pain

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