Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder

Zlomuzica, Armin; Woud, Marcella L.; Machulska, Alla; Kleimt, Katharina; Dietrich, Lisa; Wolf, Oliver T.; Assion, Hans-Joerg; Huston, Joseph P.; Silva, Maria A. de Souza; Dere, Ekrem

doi:10.1016/j.pnpbp.2017.12.014

Cited by 39 publications

(27 citation statements)

References 64 publications

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“…Particularly impaired in veterans and auditory stimuli 15,21) The importance of emotional context 19,20) Increased attention to threat-related stimuli [22][23][24][25] Difficulty in inhibitory response from distracter 26) Memory Lack of consistency in memory loss 11,15,27) Relatively consistent impairment in language memory 27) Differences by type of trauma [27][28][29] Negative effect on episodic memory [30][31][32][33] Change of existing memory/formation of negative memory [34][35][36][37] Difficulty in memory suppression 38,39) Learning Lack of consistency in learning ability loss 11,15,18) Impaired in language learning and veterans/elderly 11,15,40) Executive function Impairment of executive function 11,15,41,42) Influence independent of depression 42) Visuospatial function Relatively small effect 11,15) Relevance to abused children 29,43) 억보다…”

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confidence: 99%

Posttraumatic Stress Disorder and Cognitive Fucntioning: A Literature Review

한

Yun

Choi

2020

J Korean Neuropsychiatr Assoc

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confidence: 99%

Posttraumatic Stress Disorder and Cognitive Fucntioning: A Literature Review

한

Yun

Choi

2020

J Korean Neuropsychiatr Assoc

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“…29,30 PTSD is characterized by several cognitive impairments that affect memory (especially episodic memory), executive functioning, and self-referential processing. [31][32][33] Hermelink et al found an association between pretreatment cognitive impairment, as assessed by a neuropsychological battery, and PTSD after local or systemic treatment in cancer patients. 34 Based on the IQCODE, an indirect measure of cognitive performance, our study showed that previous cognitive impairment may exert a protective effect against developing PTSD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for post-traumatic stress, anxiety, and depression in sepsis survivors after ICU discharge

Calsavara

Costa

Nobre

et al. 2021

Braz. J. Psychiatry

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Objective: Sepsis survivors present a wide range of sequelae; few studies have evaluated psychiatric disorders after sepsis. The objective of this study was to define the prevalence of and risk factors for anxiety, depression and post-traumatic stress disorder (PTSD) symptoms in sepsis survivors. Method: Anxiety, depression and post-traumatic stress symptoms in severe sepsis and septic shock survivors 24 h and 1 year after intensive care unit (ICU) discharge were assessed using the Beck Anxiety/Depression Inventories and the PTSD Checklist-Civilian Version. Differences in psychiatric symptoms over time and the influence of variables on these symptoms were calculated with marginal models. Results: A total of 33 patients were enrolled in the study. The frequencies of anxiety, depression and PTSD 24 h after ICU discharge were 67%, 49%, and 46%, respectively and, among patients reevaluated 1 year after ICU discharge, the frequencies were 38%, 50%, and 31%, respectively. Factors associated with PTSD included serum S100B level, age, and Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) score. Factors associated with depression included patient age and cumulative dose of dobutamine. IQCODE score and cumulative dose of haloperidol in the ICU were associated with anxiety after ICU discharge. Conclusion: Patients who survive sepsis have high levels of psychiatric symptoms. Sepsis and associated treatment-related exposures may have a role in increasing the risk of subsequent depression, anxiety, and PTSD.

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“…Notably, in our study this effect cannot be attributed to changes in WMC. Future studies may want to address the role of WMC in explicit memory more directly, using extended memory tests that allow a more fine-grained exploration of recognition memory, e.g., establishing hit and false alarm rates or item versus relational aspects of memories (regarding the latter, see Zlomuzica et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Investigating the effect of proactive interference control training on intrusive memories

Woud

Heeren

Shkreli

et al. 2019

European Journal of Psychotraumatology

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Intrusive re-experiencing is a hallmark symptom of Posttraumatic Stress Disorder (PTSD). According to prominent models of intrusive phenomena, intrusive memories may result from impairments in the efficiency of working memory capacity (WMC), more specifically proactive interference control. Yet, experimental research is scarce. Therefore, the present study aimed to investigate experimentally the role of proactive interference control in intrusive memories. We randomly assigned 57 healthy participants to either receive a high interference control training or a low interference control training. Participants were then exposed to highly distressing film clips. WMC was assessed before and after the training. Intrusion symptoms were assessed directly post-training and after one week using an Intrusion Provocation Task (IPT), a one-week intrusions diary, and the retrospective intrusion subscale of the Impact of Event Sale-Revised (IES-R). Results indicated that both groups reported improvements in WMC and fewer intrusions on the second IPT post-training, with no differences between groups. Similarly, no group differences on intrusions were found at one-week follow-up (i.e., intrusion diary and IES-R). To conclude, these data are not consistent with the hypothesis that WMC plays a role in intrusive re-experiencing. Implications for future research are discussed.

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Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder

Cited by 39 publications

References 64 publications

Posttraumatic Stress Disorder and Cognitive Fucntioning: A Literature Review

Posttraumatic Stress Disorder and Cognitive Fucntioning: A Literature Review

Prevalence and risk factors for post-traumatic stress, anxiety, and depression in sepsis survivors after ICU discharge

Investigating the effect of proactive interference control training on intrusive memories

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