Deficits in regional taste sensitivity in patients with schizophrenia

Balderston, K.; Moberg, Paul J.; Turetsky, B.; Palecanda, Bala; Doty, Richard L.; Gur, R.E.

doi:10.1016/s0920-9964(03)80889-7

Cited by 2 publications

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“…Tasting or imagining the flavor of food reached the first position among 34 candidate mental domains which probably relates to epidemiological studies that estimate 7–31% of patients with schizophrenia experience some form of gustatory hallucination (Baethge et al, ; Connolly & Gittleson, ; Lewandowski, DePaola, Camsari, Cohen, & Ongur, ; Thomas et al, ). The scarce studies directly examining gustation in patients with schizophrenia reported a significant deficit in their sensitivity for different tastes (Balderston et al, ), such as the bitter‐tasting antiheroic compound phenylthiocarbamide (Moberg et al, ; Moberg et al, ). Additionally, there is some tentative evidence for abnormalities in brain regions related to gustation including the insula, thalamus, and orbitofrontal cortex (Balderston et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The scarce studies directly examining gustation in patients with schizophrenia reported a significant deficit in their sensitivity for different tastes (Balderston et al, ), such as the bitter‐tasting antiheroic compound phenylthiocarbamide (Moberg et al, ; Moberg et al, ). Additionally, there is some tentative evidence for abnormalities in brain regions related to gustation including the insula, thalamus, and orbitofrontal cortex (Balderston et al, ). For instance, taste chemoreceptors responses seem to be reduced in the dorsolateral prefrontal cortex (Ansoleaga et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, there is some tentative evidence for abnormalities in brain regions related to gustation including the insula, thalamus, and orbitofrontal cortex (Balderston et al, 2003). For instance, taste chemoreceptors responses seem to be reduced in the dorsolateral prefrontal cortex (Ansoleaga et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Brain‐based ranking of cognitive domains to predict schizophrenia

Karrer

Bassett

Derntl

et al. 2019

Human Brain Mapping

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Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions, we developed a data‐driven machine‐learning strategy and provide a proof of principle in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neurotopographical maps. We then examined how the ensuing meta‐analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well‐studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease relevant, including self‐oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain‐based ranking of cognitive domains to predict schizophrenia

Karrer

Bassett

Derntl

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Tasting or imagining the flavor of food reached the 1 st position among 34 candidate mental domains which probably relates to epidemiological studies that estimate 7% to 31% of patients with schizophrenia experience some form of gustatory hallucination (Baethge et al, 2005; Connolly and Gittleson, 1971; Lewandowski et al, 2009; Thomas et al, 2007). The scarce studies directly examining gustation in patients with schizophrenia reported a significant deficit in their sensitivity for different tastes (Balderston et al, 2003), such as the bitter-tasting antiheroic compound phenylthiocarbamide (Moberg et al, 2007; Moberg et al, 2005). Additionally, there is some tentative evidence for abnormalities in brain regions related to gustation including the insula, thalamus, and orbitofrontal cortex (Balderston et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…The scarce studies directly examining gustation in patients with schizophrenia reported a significant deficit in their sensitivity for different tastes (Balderston et al, 2003), such as the bitter-tasting antiheroic compound phenylthiocarbamide (Moberg et al, 2007; Moberg et al, 2005). Additionally, there is some tentative evidence for abnormalities in brain regions related to gustation including the insula, thalamus, and orbitofrontal cortex (Balderston et al, 2003). For instance, taste chemoreceptors responses seem to be reduced in the dorsolateral prefrontal cortex (Ansoleaga et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Brain-based ranking of cognitive domains to predict schizophrenia

Karrer

Bassett

Derntl

et al. 2018

Preprint

View full text Add to dashboard Cite

Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalogue of cognitive functions, we developed a bottom-up machine-learning strategy and provide a proof of principle in a multi-site clinical dataset (n=324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neuro-topographical maps. We then examined how the ensuing meta-analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well-studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease-relevant, including self-oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

show abstract

Deficits in regional taste sensitivity in patients with schizophrenia

Cited by 2 publications

References 0 publications

Brain‐based ranking of cognitive domains to predict schizophrenia

Brain‐based ranking of cognitive domains to predict schizophrenia

Brain-based ranking of cognitive domains to predict schizophrenia

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